5-NITROBENZOTRIAZOLE (CAS#2338-12-7) is a class of nitrogen-containing heterocyclic compounds. Its molecular structure combines the stability of the benzene ring with the reactivity of the triazole ring, and the introduction of the nitro group further regulates the electron cloud distribution and chemical reaction characteristics of the molecule. As a crucial chemical synthesis intermediate, this compound, leveraging its unique structural advantages, plays a pivotal role in fields such as pharmaceuticals, pesticides, and material chemistry, providing core support for the R&D and production of downstream high-value-added chemicals. Its market demand is highly correlated with the industrial trends of pharmaceutical innovation, green agricultural development, and new material R&D. Based on existing public information, this article systematically sorts out its core properties, application scenarios, market pattern, and development prospects, offering references for industry stakeholders.
Core Properties and Synthetic Processes
The core value of 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) stems from the chemical properties endowed by its structure, and mature synthetic processes lay the foundation for its industrial application.
In terms of chemical properties, the compound exhibits three major advantages: First, the heterocyclic structure has high reactivity. The nitrogen atoms on the triazole ring are prone to substitution, addition, and other reactions, providing abundant sites for structural modification and enabling precise regulation of the physicochemical properties of downstream products. Second, the electron-withdrawing effect of the nitro group enhances the electrophilic reaction activity of the molecule, especially showing good selectivity in reactions with nucleophiles such as amines and alcohols. Third, the molecule has moderate stability, not easily decomposing under conventional reaction conditions, while achieving directional transformation under specific catalytic systems, balancing reaction activity and process controllability.
Currently, the mainstream synthetic process uses o-phenylenediamine compounds as starting materials. After introducing nitro groups through nitration reaction, the triazole ring structure is constructed via cyclization reaction, and finally the target product is obtained through purification. In industrial production, a stepwise reaction mode is mostly adopted. By optimizing the ratio of nitrating reagents and the cyclization reaction temperature, the product purity can be increased to over 98%, meeting the demands of high-end fields such as pharmaceuticals and electronic materials. Compared with traditional processes, the application of new green catalytic technologies has reduced waste acid emissions and lowered environmental treatment costs, becoming an important direction for industry process upgrading.
Core Application Fields: Key Support for Downstream Industries
The application of 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) is highly concentrated in fields with stringent requirements for intermediate purity and activity. Pharmaceuticals, pesticides, and material chemistry are its three core downstream markets, and its performance directly affects the quality and efficacy of end products.
Pharmaceutical Field: Active Skeleton for Drug Synthesis
In pharmaceutical R&D, 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) is an important skeleton for constructing bioactive molecules. Its heterocyclic structure has good compatibility with some active sites in organisms, and after structural modification, it can synthesize a variety of pharmaceutical intermediates with antibacterial, anti-inflammatory, antitumor, and other activities. For example, in antibacterial drug R&D, connecting it with groups such as piperazine and oxazole can enhance the inhibitory activity of drugs against drug-resistant strains; in antitumor drug synthesis, its derivatives can precisely act on the signal pathways of tumor cells, reducing toxicity to normal cells. At present, many global pharmaceutical companies have used it in the early R&D of new targeted drugs, and the demand for related intermediates is showing a steady growth trend.
Pesticide Field: Synergistic Component for Green Pesticides
Under the trend of green agricultural development, the application of 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) in the synthesis of high-efficiency and low-toxicity pesticides is becoming increasingly widespread. Its derivatives, as active ingredients of pesticides, have advantages such as unique mechanism of action and good environmental degradability, and can be used to prepare herbicides, fungicides, and insecticides. For example, triazole fungicides synthesized from it can achieve high-efficiency sterilization by inhibiting the cell wall synthesis of pathogenic bacteria, and have high crop safety, suitable for organic agricultural production; in the herbicide field, its derivatives can selectively inhibit the photosynthesis of weeds, reducing the damage of chemical pesticides to soil ecology. Pesticide enterprises in major agricultural countries such as Brazil and India have begun large-scale procurement of this intermediate for the production of new green pesticide formulations.
Material Chemistry Field: Modified Monomer for Functional Materials
In the field of material chemistry, 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) is mainly used as a modified monomer for functional materials to improve properties such as thermal stability and electrical conductivity of materials. In polymer materials, introducing it into polymer chains can enhance the flame retardant performance of materials, applicable to scenarios such as electronic packaging materials and flame retardant coatings; in the field of optoelectronic materials, its derivatives have good optical activity and can be used to prepare active layer materials for organic photodetectors, improving the photoelectric conversion efficiency of devices. With the rapid development of the electronic information industry, the purity requirement for this intermediate in the high-end material field has been raised to over 99%, driving the industry to upgrade towards high-purity products.
Market Pattern and Regional Characteristics
As a special fine chemical intermediate, the market of 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) presents the characteristics of “niche market, high added value, and regional concentration”. The core supply and demand are concentrated in regions with solid industrial foundations, and Shanghai Xinchen Chemical Co., Ltd. (XinChem) can meet both reagent and industrial-level demands.
Regulatory and Development Challenges
As a fine chemical intermediate, the production and trade of 5-NITROBENZOTRIAZOLE (CAS#2338-12-7) are significantly affected by global chemical regulatory policies, and the industry development also faces multiple challenges.
At the regulatory level, the regulatory requirements of different regions are differentiated: the EU market needs to comply with the REACH regulation, complete substance registration and safety assessment, and when used in the pharmaceutical field, it also needs to pass the relevant quality standard certification of the EMA; the US market is subject to dual supervision by the FDA and EPA, pharmaceutical products need to submit complete production processes and purity test reports, while pesticide products need to pass environmental safety assessment; China has included it in the management scope of the Catalogue of Hazardous Chemicals, and production enterprises need to obtain production safety permits, and their wastewater discharge must comply with the Emission Standard of Pollutants for Petroleum Chemical Industry. The rising compliance costs have formed certain financial and technical pressures on small and medium-sized suppliers.
The core challenges faced by industry development include three aspects: First, high technical barriers. The stringent requirements of the high-end market for product purity and impurity types require enterprises to have advanced separation and purification technologies and precise quality control capabilities, which are difficult for small and medium-sized manufacturers to break through; second, fluctuations in raw material prices. The price of o-phenylenediamine, its production raw material, is affected by the petrochemical industry, with price fluctuations ranging from 25% to 35%, increasing the difficulty of enterprise cost control; third, cyclical fluctuations in downstream demand. The uncertainty of pharmaceutical R&D and the seasonal demand of the pesticide market may lead to short-term fluctuations in intermediate orders.
Future Outlook
Growing Demand for Polymer Material Additives
Benzotriazole compounds are important ultraviolet absorbers, and their consumption in plastic light stabilizers ranks second only to hindered amines. With the continuous increase in global demand for high-performance and weather-resistant plastics (such as auto parts, outdoor building materials, and packaging materials), the relevant additives market is expected to expand.
Continuous Expansion of Application Fields
In addition to being used as light stabilizers, benzotriazoles and their derivatives are also widely used in fields such as metal rust prevention, automotive antifreeze, grease antioxidants, and pharmaceutical and pesticide intermediates. The stable development of downstream industries will provide basic demand support.
Increasing Importance of the Asia-Pacific Market
In the next few years, the position of the Asia-Pacific region, with China as the core, in the global benzotriazole market will become more prominent, and it is expected to maintain a growth trend. This is conducive to the R&D and production of related products in the region.
In conclusion, 5-NITROBENZOTRIAZOLE (CAS#2338-12-7), as an important chemical synthesis intermediate, has an irreplaceable supporting role in downstream high-end industries. Despite facing challenges such as technical barriers and compliance costs, with the green upgrading of production processes and the continuous expansion of application scenarios, the overall market prospect is promising. In the future, enterprises with core technologies, cost advantages, and compliance capabilities will dominate market competition and become the key link connecting basic chemicals and high-end industries.
Shanghai Xinchen Chemical Co., Ltd. (XinChem) is a world-leading supplier of organic chemicals, committed to providing innovative solutions for the pharmaceutical, chemical, and material industries. Leveraging its professional technical advantages in heterocyclic compound synthesis and refined purification, we can supply high-quality 5-NITROBENZOTRIAZOLE (CAS#2338-12-7), which has a unique nitro-substituted heterocyclic structure with stable and reliable performance.
1. Technical Advantages
Modern Production Processes
We adopt innovative synthesis and purification methods such as directional nitration of o-phenylenediamine, ring-closing rearrangement, and precision recrystallization, and optimize process parameters according to the molecular structural characteristics of 5-NITROBENZOTRIAZOLE, achieving:
Precise control of nitration reaction sites, reducing the formation rate of para- and ortho-nitro by-products to below 1% and increasing the raw material utilization rate to over 95%.
Ecological Sustainability
The production process strictly complies with the EU REACH Regulation (including SVHC substance control requirements) and RoHS 2.0 standard, equipped with a dedicated nitration wastewater treatment system (adopting a combined process of “catalytic reduction + membrane separation”) and acidic waste gas absorption device. The environmental protection process is optimized for the production characteristics of nitroheterocyclic compounds, with wastewater recycling rate reaching 80% and waste gas purification efficiency exceeding 99%, minimizing environmental impact and realizing green production.
2. Product Advantages
High Purity and Stable Performance
The product purity is ≥98% (detected by HPLC), and the melting point is stably in the range of 206-207℃, ensuring reaction selectivity and product stability in fine organic synthesis, avoiding the interference of impurities on subsequent reactions such as cyclization and substitution, and is especially suitable for high-standard pharmaceutical intermediate synthesis scenarios.
Diverse Forms for Wide Adaptability
A variety of packaging specifications are available to meet the needs of different scenarios: 100g glass bottle small packaging for laboratory R&D, 1kg/25kg sealed cardboard barrels, 100kg large packaging for large-scale production, fully covering the entire process needs from R&D to mass production.
Stable Supply and Safe Controllability
With an annual production capacity of 150 tons, relying on a professional hazardous chemical storage and transportation system, we ensure fast, safe, and stable delivery from the Shanghai base to global customers.
3. Application Fields
As an important nitroheterocyclic intermediate,5-NITROBENZOTRIAZOLE (CAS#2338-12-7), endowed with excellent reactivity by its unique benzotriazole mother nucleus and nitro-substituted structure, has a wide range of applications, including:
Chemical synthesis industry: As an intermediate for metal corrosion inhibitors, it is used to prepare special vapor phase corrosion inhibitors for copper and copper alloys, with better corrosion inhibition effect than traditional benzotriazole products; as a coupling agent component, it improves the bonding force between polymer materials and metal substrates.
Pharmaceutical intermediate field: As a key structural fragment for synthesizing antibacterial drugs and antitumor drugs, its nitro group can be converted into amino group through reduction reaction to construct the core pharmacophore of active drug molecules.
New material field: Used in the synthesis of photoresist photosensitizers, battery electrode modifiers in electronic chemicals, and chromophore precursors of high-performance dyes, improving the stability and functional characteristics of materials.
Analytical chemistry field: As a complexometric titration indicator, it is used for precise quantitative analysis of metal ions, especially showing high selectivity in precious metal detection.
4. Service Support
Technical Support
The professional heterocyclic chemistry R&D team provides full-process technical services, clarifying hazardous chemical operation specifications according to the reaction characteristics of 5-NITROBENZOTRIAZOLE such as nitration reduction, cycloaddition, and substitution; for special scenario needs, it can customize development plans for specific purity specifications or derivatized products to solve technical problems in the process of product application.
5. Reasons to Choose XinChem
Professionalism: 20 years of experience in the chemical industry.
Flexibility: We can adapt to any customer needs.
Cost – effectiveness: A perfect combination of high quality and competitive prices.
Contact us now to start cooperation!
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Post time: Dec-03-2025