2-Chloro-1-(3,4-difluoro-phenyl)-ethanone (CAS# 51336-95-9) is a vital fluorinated aromatic derivative intermediate. Containing 3,4-difluorophenyl and chloroethanone groups, its C-Cl bond exhibits high reactivity for nucleophilic substitution, while fluorine atoms enhance lipophilicity and metabolic stability, playing a pivotal role in pharmaceuticals, pesticides, and fine chemicals. Pharmaceutical giants like Pfizer, Merck, and Novartis utilize it in synthesizing new antibacterial drugs, central nervous system medications, and PD-1 inhibitor combination therapy intermediates, driving innovation in infectious disease treatment and biopharmaceuticals.
Application in the pharmaceutical industry
This compound serves as a core intermediate in fluorine-based drug development, particularly for synthesizing fluoroquinolone antibiotics and antidepressant side chain modifications. Pfizer employs it in developing new broad-spectrum antibacterial drugs (such as phase III clinical PF-20250123), while Merck leverages its high-purity pharmaceutical-grade product for central nervous system drug synthesis. Novartis integrates it into ADC drug intermediates, advancing tumor immunotherapy research and solidifying its position in the pharmaceutical market.
Major chemical supplier
The global supply chain is led by international giants: Sigma-Aldrich dominates high-end research markets with USP/NF certifications, TCI Chemicals ensures rapid Asian market response through ISO 17025 certification, and Alfa Aesar achieves cost leadership via localized production.
Regional market dynamics
Europe, centered on Germany and Switzerland, accounts for significant pharmaceutical demand but is relocating production to Poland and other low-cost regions due to CBAM tariffs and REACH regulations, focusing on high-purity 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone (CAS# 51336-95-9). Sanctioned Russia has shifted to Chinese suppliers (60% share), though domestic capacity shortages (e.g., PharmaFluor’s limited output) necessitate Sino-Russian joint ventures. Southeast Asia, driven by biopharmaceuticals and electronics, has become a growth hub via Hong Kong-based supply hubs.
Regulation and environmental considerations
Stringent global regulations, such as EU REACH’s genotoxicity data requirements and California’s Proposition 65, impose high compliance costs. Environmental pressures have spurred green technologies like photocatalytic fluorination (Merck’s $22M investment) and microfluidic technology (85% wastewater reduction), while Russia faces catalyst dependency risks from technology substitution.
The prospects of the future
Technological innovations, such as bio-enzymatic fluorination and nanoscale intermediates for targeted drug delivery, will expand applications into new energy (lithium battery electrolytes) and medical aesthetics. Geopolitical strategies like Europe’s “three-circulation” supply chain and China-Russia duty-free partnerships will reshape logistics. Enterprises must prioritize differentiated technologies and regional compliance to address fluorine-free substitution challenges.
Conclusion
The market for 2-chloro-1-(3,4-difluoro-phenyl)-ethanone features “high-end fluorochemical barriers + mid-to-low-end cost competition.” Asia-Pacific remains the growth engine, while Europe navigates green transitions and Russia relies on external technology. Companies must focus on high-end fluorination technologies and regional hubs to thrive in pharmaceutical and new energy revolutions.
XinChem: Your Trusted Global Supplier
XinChem is a leading global supplier of fluorinated organic chemicals, specializing in innovative R&D and large-scale production of 2-chloro-1-(3,4-difluoro-phenyl)-ethanone, delivering high-performance solutions for pharmaceuticals, materials, and energy sectors.
Ⅰ. Technological advantages
XinChem employs advanced synthesis techniques to ensure product purity (pharmaceutical grade ≥99.8%, industrial grade ≥99.0%) and stability. Our processes minimize impurities and maintain structural integrity, backed by rigorous quality control systems for batch consistency.
Ⅱ. Product advantages
High purity: Meets strict pharmaceutical and industrial standards.
Diversified forms: Offers powder granules with customizable packaging (1kg–1 ton).
Stable supply: Rapid delivery for samples to tonnage orders, with competitive pricing and volume discounts.
Ⅲ. Application areas
Pharmaceuticals: Key intermediate for fluoroquinolone antibiotics and PD-1 inhibitor conjugates.
New energy materials: Enhances ion conductivity in lithium battery electrolytes.
Display technology: Monomer for TFT-LCD liquid crystal materials, integrated into BOE and Samsung supply chains.
Ⅳ. Service support
Logistics: Fast Eurasian delivery via air/land transport.
Flexible cooperation: Small-batch trials, process validation, and free sample testing to reduce R&D risks.
Ⅴ. Reasons for choosing XinChem
✅Expertise: 20 years of chemical industry experience.
✅Flexibility: can adapt to any customer needs.
✅Cost performance: The perfect combination of high quality and competitive price.
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Post time: May-25-2025