The Electron-Deficient Aromatic Aldehyde Building Block for 9-Nitrocamptothecin, Porphyrin Catalysts, and Advanced Functional Materials: 2,6-Dinitrobenzaldehyde (CAS# 606-31-5)

2,6-Dinitrobenzaldehyde (CAS# 606-31-5), also known as 2,6-dinitrobenzenecarboxaldehyde or 2,6-dinitrobenzaldehyde, is an electron-deficient aromatic aldehyde with the molecular formula C₇H₄N₂O₅ and a molecular weight of 196.12 g/mol. Its molecular structure consists of a benzaldehyde core bearing two strongly electron-withdrawing nitro groups at the 2- and 6-positions, flanking the aldehyde functionality. This specific ortho,ortho′-dinitro substitution pattern—distinguishing it from other dinitrobenzaldehyde regioisomers—creates one of the most electron-poor aromatic aldehydes available, dramatically enhancing the electrophilicity of the aldehyde carbon and enabling unique reactivity in nucleophilic addition, condensation, and porphyrin-forming reactions.

As a yellow crystalline solid with a melting point of 120–122°C and a density of 1.571 g/cm³, the compound is almost insoluble in water but soluble in many organic solvents such as ethanol and dichloromethane. It exhibits a strong pungent odor and should be stored at 2–8°C in a tightly sealed container protected from light and moisture. The compound is typically supplied at ≥95% and ≥98% purity (HPLC/GC) and is classified as an irritant (Xi) with risk codes R36/37/38 under GHS, carrying a WGK Germany classification of 3.

2,6-Dinitrobenzaldehyde is a strategically important electron-deficient aromatic aldehyde that serves as the definitive precursor for the anticancer agent 9-nitrocamptothecin (rubitecan) and as a versatile building block for the synthesis of bis-pocket porphyrins with catalytic activity in alkane oxidation, Schiff base ligands for analytical detection of amino acids and proteins, and advanced functional materials. Its unique combination of extreme electron deficiency, dual nitro substitution, and aldehyde reactivity positions it as an indispensable intermediate in pharmaceutical synthesis, porphyrin chemistry, and analytical reagent development. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regulatory landscape, and future outlook of this strategically important aromatic aldehyde building block.

Key Properties and Reactivity Profile

2,6-Dinitrobenzaldehyde (CAS# 606-31-5) is a regioisomer-specific dinitrobenzaldehyde whose value derives from the extreme electron deficiency of its aromatic ring and the enhanced electrophilicity of its aldehyde group.

Key physicochemical parameters include:

• Molecular Formula: C₇H₄N₂O₅
• Molecular Weight: 196.12 g/mol
• CAS Number: 606-31-5
• EINECS Number: 210-113-9
• MDL Number: MFCD00007133
• Synonyms: 2,6-Dinitrobenzenecarboxaldehyde; Benzaldehyde, 2,6-dinitro-; (O₂N)₂C₆H₃CHO
• Appearance: Yellow crystalline solid or powder
• Purity: ≥95% (HPLC); ≥98% (HPLC/GC) available
• Melting Point: 120–122°C
• Boiling Point: 363.2±32.0°C at 760 mmHg (predicted)
• Density: 1.571±0.06 g/cm³ (predicted)
• Flash Point: 192.1°C
• LogP: 1.50
• Solubility: Almost insoluble in water; soluble in ethanol, dichloromethane, and other organic solvents
• Odor: Strong pungent odor
• Storage: 2–8°C, protect from light and moisture, store long-term at 2–8°C
• GHS Classification: Warning; H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
• Hazard Symbols: Xi – Irritant
• Risk Codes: R36/37/38 – Irritating to eyes, respiratory system, and skin
• Safety Description: S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice); S36 (Wear suitable protective clothing)
• WGK Germany: 3 (high hazard to water)
• RTECS: CU5957500
• HS Code: 2913000090

The compound’s reactivity is defined by its two ortho-nitro groups, which create an exceptionally electron-poor aromatic ring. This electronic environment dramatically enhances the electrophilicity of the aldehyde carbon, making it highly reactive toward nucleophiles such as amines and thiols. The reaction pathway involves the formation of a Schiff base intermediate, which undergoes nucleophilic attack to yield stable adducts suitable for subsequent organic reactions or spectroscopic analysis. The compound operates as a strong electrophile and readily engages with nucleophiles, including amines and thiols, to yield adducts via Schiff base formation—a property that underpins its utility in analytical detection methods for amino acids and proteins. The 2,6-dinitro substitution pattern is also critical for the compound’s role in porphyrin synthesis, where the electron-withdrawing nitro groups modulate the electronic properties of the resulting porphyrin macrocycle and influence its catalytic activity.

Core Application Fields and Demand

Market demand for 2,6-dinitrobenzaldehyde (CAS# 606-31-5) is concentrated in four primary sectors: pharmaceutical intermediates and API manufacturing (approximately 40–45% of global consumption), porphyrin and catalyst synthesis (approximately 20–25%), analytical reagents and biochemical detection (approximately 15–20%), and specialty chemicals and functional materials (approximately 15–20%). Its unique combination of extreme electron deficiency and versatile aldehyde reactivity serves as the core driver of sustained demand growth.

In pharmaceutical intermediates and API manufacturing, 2,6-dinitrobenzaldehyde is the essential intermediate for the synthesis of 9-nitrocamptothecin (rubitecan, 9-NC, RFS-2000, Orathecin) —a topoisomerase I inhibitor investigated for the treatment of pancreatic cancer and other solid tumors. The compound is an important raw material for the synthesis of 9-nitrocamptothecin and 9-aminocamptothecin. The synthetic route involves the reaction of 2,6-dinitrobenzaldehyde with ethylene glycol and p-toluenesulfonic acid in refluxing toluene to form the corresponding ethylene ketal, followed by reduction with sodium sulfide in refluxing ethanol/water to yield 2-amino-6-nitrobenzaldehyde ethylene ketal, which upon hydrolysis with aqueous sulfuric acid affords 2-amino-6-nitrobenzaldehyde—a key intermediate in the camptothecin-derived anticancer drug synthesis. The selective mono-reduction of one nitro group of 2,6-dinitrobenzaldehyde is a critical step that enables the construction of the fused quinoline ring system characteristic of camptothecin analogs. The compound is also used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, serving as a versatile building block for drug discovery programs.

In porphyrin and catalyst synthesis, 2,6-dinitrobenzaldehyde is a critical building block for the synthesis of free base tetrakis(2,6-dinitrophenyl)porphyrin and other bis-pocket porphyrins. Tetrakis(2′,6′-dinitrophenyl)porphyrin has been characterized spectroscopically and exhibits catalytic activity in alkane oxidation processes. The electron-withdrawing nitro groups in the 2,6-positions create a sterically hindered, electron-poor environment around the porphyrin core, which modulates the redox properties of the metalloporphyrin and enhances its catalytic activity and selectivity in oxidation reactions. These porphyrin catalysts are valuable in green chemistry applications for the selective oxidation of hydrocarbons under mild conditions.

In analytical reagents and biochemical detection, 2,6-dinitrobenzaldehyde serves as a valuable reagent for the detection and analysis of amino acids and proteins. Operating as an electrophile, the compound readily engages with nucleophiles like amines and thiols to yield adducts through a pathway involving Schiff base intermediate formation. The resulting products can be analyzed using various spectroscopic techniques, making 2,6-dinitrobenzaldehyde a useful tool for advancing analytical methods for detecting a wide range of substances, including amino acids and proteins. The compound is also used as a precursor for creating a new spin trap of the nitrone type, which finds applications in studying short-lived radicals—a critical capability in mechanistic studies of radical-mediated reactions and oxidative stress research.

In specialty chemicals and functional materials, 2,6-dinitrobenzaldehyde is employed in the production of dyes, pigments, and other specialty chemicals. The compound is utilized in the production of dyes due to its vibrant color properties. It is also used as a versatile intermediate for constructing complex molecular architectures, including multi-step synthesis routes beginning with the nitration of 4-hydroxybenzaldehyde to produce 2,6-dinitro-4-hydroxybenzaldehyde, followed by reaction with thionyl chloride to yield 4-chloro-2,6-dinitrobenzaldehyde—a versatile intermediate for further functionalization. The compound is also employed as a chemical reagent for preparing other compounds and as a synthesis intermediate for various organic transformations.

Major Market Participants

The global supply system for 2,6-dinitrobenzaldehyde (CAS# 606-31-5) features a pattern of “specialized fine chemical manufacturers, multinational research chemical distributors, and Chinese producers serving distinct market segments.” As a specialized electron-deficient aromatic aldehyde rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to pharmaceutical R&D, porphyrin chemistry, and analytical applications. According to the 2,6-Dinitrobenzaldehyde (CAS 606-31-5) Industry Research 2025, the global market report provides comprehensive data on manufacturers, distributors, prices, end-users, and downstream industries across Europe, Asia, North America, and other regions, with forecasts extending through 2029.

In the global research and high-purity segment, key international suppliers include Santa Cruz Biotechnology, offering the compound at ≥98% purity under catalog number sc-238427, with 1 g packaging priced at $310.00 for research applications. Sigma-Aldrich (Merck) offers the compound at 98% purity under catalog number 117501, with specifications including a melting point of 120–122°C and a molecular weight of 196.12 g/mol. AK Scientific (AKSci) offers the compound at 98% purity under product code 9370AJ, with DOT/IATA classification as non-hazardous material and long-term storage at 2–8°C. Aladdin Scientific offers the compound at ≥95% purity under catalog number D300378, with 250 mg packaging available. ChemScene offers the compound under catalog number CS-0003922 with multiple packaging options. BenchChem offers the compound under catalog number B1206409 with molecular weight 196.12 g/mol. Ambeed offers the compound under catalog number A315798 for research applications. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications.

In the industrial and large-scale production segment, Chinese manufacturers have emerged as significant players in the global supply chain. XinChem is a reliable manufacturer and supplier of high-purity 2,6-dinitrobenzaldehyde from China, offering the compound with stringent quality standards for use in 9-nitrocamptothecin synthesis, porphyrin catalyst development, and analytical reagent applications. XinChem provides the compound as a yellow crystalline solid with comprehensive quality documentation and flexible packaging options, including batch-specific Certificates of Analysis (COA), customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing. Other Chinese suppliers include Shaanxi Dideu Medichem (陕西缔都医药化工), Shanghai Aladdin Biochemical Technology (上海阿拉丁生化科技), Ningbo Jinuo Chemicals (宁波季诺化学品), Hubei Tuobang Chemical (湖北拓邦化工), Zibo Hangyu Biotechnology (淄博航宇生物科技), Hubei Guangao Biotechnology (湖北广奥生物科技), Suzhou Senfeida Chemical (苏州市森菲达化工), Hefei TNJ Chemical Industry, Hebei Chuanghai Biotechnology, Antimex Chemical, and Changchun Haofei Import & Export Trade. Chinese suppliers offer the compound at various purity grades (typically 95–99%) and packaging options—from grams to multi-kilogram quantities—serving both domestic and export markets. Production scale capabilities include up to 200 kg quantities with packaging options of 25 kg drums and 200 kg drums. The compound is available at prices ranging from approximately RMB 588.90 for laboratory quantities to RMB 2,968.90 for larger quantities.

Regional Market Dynamics

The global 2,6-dinitrobenzaldehyde market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, porphyrin chemistry, and analytical reagent industries in these regions. According to the 2,6-Dinitrobenzaldehyde (CAS 606-31-5) Industry Research 2025, the global market analysis covers constraints, drivers, and opportunities from 2019 to 2024, supply and demand dynamics, suppliers and regional overviews across Europe, Asia, North America, and other regions, with forecasts through 2029.

The Asia-Pacific region has emerged as a significant production hub for 2,6-dinitrobenzaldehyde, with China hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing pharmaceutical and specialty chemical industries. Chinese suppliers offer the compound at various purity grades (typically 95–99%) and packaging options, serving both domestic and export markets. The growing pharmaceutical R&D, anticancer drug development, and porphyrin chemistry sectors in China, Japan, South Korea, and India continue to drive regional consumption growth. The compound is listed as a pharmaceutical intermediate and fine chemical intermediate in the Chinese market, with multiple suppliers offering the product in packaging sizes ranging from 250 mg to 200 kg. Chinese manufacturers have optimized the synthesis of 2,6-dinitrobenzaldehyde from 2,6-dinitrotoluene via combined ozonation with hydrogen peroxide and UV radiation, establishing a reliable industrial supply chain.

North America remains a key market for high-purity and research-grade 2,6-dinitrobenzaldehyde, driven by demand from the pharmaceutical industry, porphyrin chemistry research, and analytical reagent applications. The United States hosts numerous research organizations, pharmaceutical companies, and academic institutions that require high-quality electron-deficient aromatic aldehydes for anticancer drug development, porphyrin catalyst synthesis, and analytical method development. Santa Cruz Biotechnology, Sigma-Aldrich, and AK Scientific serve the North American market with extensive distribution networks. The region’s well-established regulatory framework and emphasis on product quality support demand for high-grade research chemicals and pharmaceutical intermediates.

Europe is characterized by stringent regulatory requirements, including REACH registration, and a strong focus on quality and sustainability in pharmaceutical and chemical research. European pharmaceutical companies, porphyrin chemistry laboratories, and research institutions demand high-purity dinitrobenzaldehyde derivatives with comprehensive documentation. The compound has an EINECS number of 210-113-9 and is subject to REACH registration requirements for import and use. European suppliers and distributors serve the market with in-stock availability and established distribution networks.

Japan represents a specialized market where 2,6-dinitrobenzaldehyde is supplied for pharmaceutical research, porphyrin catalyst development, and analytical reagent applications.

Regulatory and Safety Considerations

As a highly electron-deficient dinitroaromatic aldehyde and pharmaceutical intermediate, 2,6-dinitrobenzaldehyde (CAS# 606-31-5) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.

GHS classification and handling: 2,6-Dinitrobenzaldehyde is classified with the signal word “Warning”. Hazard statements include H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). The compound is classified as Skin Irrit. 2, Eye Irrit. 2, and STOT SE 3 (respiratory system). Precautionary statements include P261 (Avoid breathing dust/fume/gas/mist/vapours/spray), P264 (Wash skin thoroughly after handling), P271 (Use only outdoors or in a well-ventilated area), P280 (Wear protective gloves/protective clothing/eye protection/face protection), P302+P352 (IF ON SKIN: Wash with plenty of soap and water), P304+P340 (IF INHALED: Remove person to fresh air and keep comfortable for breathing), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing), and P405 (Store locked up). The compound is considered a hazardous substance according to OSHA 29 CFR 1910.1200. The WGK Germany classification is 3 (high hazard to water). The compound is classified as a combustible solid (storage class 11). RTECS number: CU5957500.

Acute and chronic health effects: Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 grams may be fatal or may produce serious damage to health. The substance and/or its metabolites may bind to hemoglobin inhibiting normal uptake of oxygen, a condition known as methemoglobinemia, with symptoms including cyanosis, breathing difficulties, and in severe cases, convulsions and respiratory depression. The material can cause eye irritation and damage, skin inflammation, and respiratory irritation. Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Skin contact with the material is more likely to cause a sensitization reaction in some persons, and open cuts, abraded or irritated skin should not be exposed to this material.

Storage and stability: 2,6-Dinitrobenzaldehyde should be stored at 2–8°C in a tightly sealed container protected from light and moisture. The compound is incompatible with strong oxidizing agents and strong bases. It should be kept away from heat, sparks, and open flames. Personal protective equipment including chemical-resistant gloves, protective clothing, eye protection, and face protection should be worn during handling, and operations should be conducted in a well-ventilated environment or fume hood.

Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements for import and use. The compound has an EINECS number of 210-113-9. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, 2,6-dinitrobenzaldehyde is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. For pharmaceutical intermediate applications, manufacturers must comply with relevant FDA regulations and quality standards. The compound is not classified as hazardous material for DOT/IATA transport purposes.

Transport information: 2,6-Dinitrobenzaldehyde is not classified as hazardous material for DOT/IATA transport purposes. Proper packaging, labeling, and documentation are nevertheless required for international shipping. The HS code for the compound is 2913000090 (halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912).

Environmental considerations: 2,6-Dinitrobenzaldehyde is classified as harmful to aquatic organisms and may cause long-term adverse effects in the aquatic environment. The WGK Germany classification of 3 indicates high hazard to water. The compound requires responsible handling and disposal, with appropriate containment measures to prevent environmental release. The development of greener synthesis methodologies and waste treatment protocols is an ongoing focus in the industry.

Future Outlook

The market outlook for 2,6-dinitrobenzaldehyde is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized electron-deficient aromatic aldehyde, its essential role as the precursor for 9-nitrocamptothecin and its utility in porphyrin catalyst synthesis position it for steady growth in the coming years. The global 2,6-dinitrobenzaldehyde market is forecast to maintain steady growth through 2029, driven by sustained demand from pharmaceutical, porphyrin chemistry, and analytical reagent sectors.

Key growth drivers include:

1. Expansion of the 9-nitrocamptothecin (rubitecan) market: The continued global development of 9-nitrocamptothecin—a topoisomerase I inhibitor investigated for pancreatic cancer and other solid tumors—drives demand for the key intermediate 2,6-dinitrobenzaldehyde. The compound’s role as an important raw material for the synthesis of 9-nitrocamptothecin and 9-aminocamptothecin positions it at the forefront of camptothecin-derived anticancer drug development.
2. Growth in porphyrin and metalloporphyrin catalyst research: The expanding field of porphyrin chemistry, particularly the development of bis-pocket porphyrins with catalytic activity in alkane oxidation processes, drives demand for 2,6-dinitrobenzaldehyde as a key building block. The electron-withdrawing nitro groups in the 2,6-positions modulate the redox properties of metalloporphyrins and enhance their catalytic activity, supporting demand for green chemistry applications in selective hydrocarbon oxidation.
3. Increasing demand for analytical reagents and spin traps: The growing use of 2,6-dinitrobenzaldehyde as a precursor for nitrone-type spin traps for studying short-lived radicals and as a reagent for detecting amino acids and proteins drives demand from analytical chemistry and biochemical research laboratories. The compound’s ability to form stable Schiff base adducts with amines and thiols makes it a valuable tool for advancing analytical methods.
4. Expansion of pharmaceutical R&D in Asia: The growth of pharmaceutical R&D and API manufacturing in China and India—driven by increasing investment in generic drug production and innovative drug discovery—supports demand for high-quality pharmaceutical intermediates and building blocks.
5. Growth in specialty chemicals and functional materials: The expanding market for specialty dyes, pigments, and functional materials creates additional opportunities for 2,6-dinitrobenzaldehyde as a versatile electron-deficient building block for constructing complex molecular architectures.

Challenges and considerations:

• Hazardous material handling: The compound’s classification as an irritant (H315, H319, H335) and its potential to cause methemoglobinemia upon ingestion require appropriate safety measures during handling and storage.
• Environmental toxicity: The compound’s classification as harmful to aquatic organisms with long-lasting effects (WGK 3) requires responsible handling and disposal, with appropriate containment measures.
• Limited scale: As a specialized electron-deficient aromatic aldehyde, the market for 2,6-dinitrobenzaldehyde is smaller than that of commodity chemicals.
• Competition from alternative building blocks: The market faces competition from other dinitrobenzaldehyde isomers and alternative synthetic routes to 9-nitrocamptothecin intermediates.
• Storage requirements: The compound requires storage at 2–8°C, which may increase handling and logistics costs.

To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, porphyrin chemistry, and analytical applications will be well-positioned to capture growing demand.

Shanghai XinChem Co., Ltd. (XinChem)

As a world-leading supplier of organic chemicals and pharmaceutical intermediates, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, porphyrin chemistry, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 2,6-Dinitrobenzaldehyde (CAS# 606-31-5) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for pharmaceutical companies, porphyrin chemistry researchers, and analytical laboratories seeking this versatile electron-deficient aromatic aldehyde building block.

1. Technical Advantages

Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2,6-dinitrobenzaldehyde products. The production process incorporates established synthetic routes—including the combined ozonation of 2,6-dinitrotoluene with hydrogen peroxide and UV radiation to yield 2,6-dinitrobenzaldehyde as the major intermediate, as well as the nitration of 3,4-dimethoxy-2-nitrobenzaldehyde following literature procedures, and the direct nitration of benzaldehyde with concentrated nitric acid under controlled acidic conditions. These routes enable the delivery of products with purity ≥95% (HPLC) and ≥98% (HPLC/GC) to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities, and batch-to-batch reproducibility, providing customers with reliable performance in 9-nitrocamptothecin synthesis, porphyrin catalyst development, and analytical reagent applications.

Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (HPLC/GC), melting point (120–122°C), density (1.571 g/cm³), and impurity profiles. XinChem offers batch-specific COA, customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing.

2. Product Advantages

High Purity and Consistent Quality
XinChem offers 2,6-dinitrobenzaldehyde with purity ≥95% (HPLC) and ≥98% (HPLC/GC) available, ensuring optimal performance in 9-nitrocamptothecin synthesis, porphyrin catalyst development, and analytical reagent applications. The product’s high purity and consistent quality minimize the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery, porphyrin chemistry, and analytical detection.

Comprehensive Specifications
Key specifications include:

• Molecular Formula: C₇H₄N₂O₅
• Molecular Weight: 196.12 g/mol
• CAS Number: 606-31-5
• EINECS Number: 210-113-9
• Synonyms: 2,6-Dinitrobenzenecarboxaldehyde; Benzaldehyde, 2,6-dinitro-; (O₂N)₂C₆H₃CHO
• MDL Number: MFCD00007133
• Appearance: Yellow crystalline solid or powder
• Purity: ≥95% (HPLC) / ≥98% (HPLC/GC) available
• Melting Point: 120–122°C
• Boiling Point: 363.2±32.0°C at 760 mmHg
• Density: 1.571±0.06 g/cm³
• LogP: 1.50
• Storage: 2–8°C, protect from light and moisture
• GHS Classification: Warning; H315, H319, H335
• RTECS: CU5957500
• HS Code: 2913000090

Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (250 mg, 1 g, 5 g, 10 g) to industrial-scale packaging (25 g, 100 g, 500 g, 1 kg, 25 kg drums) and bulk shipments (200 kg drums). Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation with appropriate protection from light and moisture.

3. Application Fields

As a versatile electron-deficient aromatic aldehyde, 2,6-Dinitrobenzaldehyde (CAS# 606-31-5) exhibits wide application value across multiple industries:

Pharmaceutical Intermediates and API Manufacturing:

• Essential intermediate for 9-nitrocamptothecin (rubitecan, 9-NC, RFS-2000, Orathecin), a topoisomerase I inhibitor for pancreatic cancer and other solid tumors
• Key raw material for 9-aminocamptothecin synthesis
• Precursor for 2-amino-6-nitrobenzaldehyde—a critical intermediate in camptothecin-derived anticancer drug synthesis
• Building block for pharmaceuticals and agrochemicals

Porphyrin and Catalyst Synthesis:

• Key building block for free base tetrakis(2,6-dinitrophenyl)porphyrin
• Precursor for bis-pocket porphyrins with catalytic activity in alkane oxidation
• Component in metalloporphyrin catalysts with modulated redox properties
• Precursor for nitrone-type spin traps for studying short-lived radicals

Analytical Reagents and Biochemical Detection:

• Reagent for detection and analysis of amino acids and proteins
• Precursor for Schiff base ligands for spectroscopic analysis
• Tool for advancing analytical methods for detecting a wide range of substances

Specialty Chemicals and Functional Materials:

• Intermediate for dyes and pigments with vibrant color properties
• Precursor for 4-chloro-2,6-dinitrobenzaldehyde—a versatile intermediate for further functionalization
• Building block for complex molecular architectures and specialty chemicals

4. Service Support

Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthetic routes, guidance on handling electron-deficient aromatic aldehydes, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.

Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including customs clearance and documentation, with appropriate temperature control (2–8°C) and moisture protection for product stability.

Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, and other regional regulations, helping customers navigate the complexities of global trade.

5. Reasons to Choose XinChem

• Professionalism: Extensive experience and deep expertise in electron-deficient aromatic aldehyde synthesis and supply.
• Quality: Rigorous quality control, high purity (≥95% to ≥98%), and adherence to international standards.
• Reliability: Stable supply, competitive pricing, and timely delivery.
• Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
• Service: Responsive technical support and comprehensive documentation including batch-specific COA.

Contact us today to start your partnership with XinChem!

Website: www.xinchem.com

Email: sales1@xinchem.com

WhatsApp: +86 18049800532