2-Amino-6-bromobenzothiazole (CAS# 15864-32-1), also known as 6-bromo-1,3-benzothiazol-2-amine, 6-bromobenzothiazol-2-amine, or 6-bromo-2-benzothiazolamine, is a halogenated heterocyclic building block with the molecular formula C₇H₅BrN₂S and a molecular weight of 229.10 g/mol. Its molecular structure features a benzothiazole core bearing a primary aromatic amine at the 2-position and a bromine atom at the 6-position—a substitution pattern that confers distinct physicochemical properties and orthogonal reactivity. As a white to light yellow crystalline powder with a melting point of 213–217°C and a predicted boiling point of 366.8±34.0°C at 760 mmHg, the compound exhibits moderate lipophilicity (calculated LogP ~2.66) and solubility in methanol.
The benzothiazole scaffold is a privileged heterocyclic core in medicinal chemistry, present in numerous bioactive molecules and pharmaceutical agents. The 6-bromo substituent enables palladium-catalyzed cross-coupling reactions—most notably Suzuki-Miyaura coupling—while the 2-amino group provides a handle for acylation, sulfonylation, and other derivatization reactions. This dual functionality, combined with the compound’s high purity (≥98% available from leading suppliers), makes 2-amino-6-bromobenzothiazole an invaluable building block for focused kinase inhibitor libraries, antimicrobial drug discovery, fluorescent probe development, and agrochemical research. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regional dynamics, regulatory landscape, and future outlook of this strategically important halogenated heterocyclic building block.
Core Application Fields and Demand
Market demand for 2-amino-6-bromobenzothiazole (CAS# 15864-32-1) is concentrated in three primary sectors: pharmaceutical R&D and kinase inhibitor discovery (approximately 50–55% of global consumption), antimicrobial and antiparasitic drug development (approximately 25–30%), and chemical biology including fluorescent probes and agrochemical research (approximately 15–20%). Its orthogonal reactivity and privileged benzothiazole scaffold serve as the core drivers of sustained demand growth across all sectors.
In pharmaceutical R&D and kinase inhibitor discovery, 2-amino-6-bromobenzothiazole serves as a critical building block for constructing focused kinase inhibitor libraries. The compound enables Suzuki-Miyaura cross-coupling at the 6-position, allowing researchers to introduce diverse aryl, heteroaryl, and alkenyl substituents for structure-activity relationship (SAR) studies. Reported kinase inhibitors derived from this scaffold have demonstrated IC₅₀ values as low as 63 nM against key therapeutic targets. The scaffold is also employed in the synthesis of PI3Kβ-targeted anti-proliferative agents, making it valuable for oncology drug discovery programs. Beyond kinase inhibition, the compound serves as a precursor for biologically active heterocycles and pharmacologically relevant small molecules targeting a range of disease areas. The dual amine/bromide functionality supports parallel acylation, sulfonylation, and late-stage functionalization, enabling efficient SAR exploration and probe development.
In antimicrobial and antiparasitic drug development, 2-amino-6-bromobenzothiazole is widely utilized as a key intermediate in the synthesis of pharmaceutical agents targeting bacterial and fungal infections. Derivatives of this compound have been investigated for a range of biological activities, including antimicrobial, antifungal, and enzyme inhibitory effects. In anthelmintic medicinal chemistry SAR studies, the compound serves as a core scaffold for exploring structure-activity relationships against parasitic infections. The compound’s derivatives are also being explored for their potential in treating various diseases, including cancer and metabolic disorders.
In chemical biology and probe development, 2-amino-6-bromobenzothiazole functions as a high-purity biochemical reagent frequently used as a synthetic intermediate or functional building block in life-science research. It serves as a precursor for fluorescent probes that enable the visualization and study of biological processes. Its unique structure allows for exploration in studies related to enzyme inhibition and receptor interactions. The compound also exhibits significant potential as a molecular scaffold for the synthesis of bioactive compounds.
In agrochemical research, 2-amino-6-bromobenzothiazole serves as a key building block in the synthesis of biologically active compounds for crop protection applications. In industrial settings, it is also used in the preparation of dyes and other specialty chemicals.
Key Properties and Reactivity Profile
2-Amino-6-bromobenzothiazole (CAS# 15864-32-1) is a halogenated heterocyclic compound whose value derives from the combination of a privileged benzothiazole scaffold and orthogonal reactivity.
Key physicochemical parameters include:
- Molecular Formula: C₇H₅BrN₂S
- Molecular Weight: 229.10 g/mol
- CAS Number: 15864-32-1
- MDL Number: MFCD00152229
- Appearance: White to light yellow to light orange powder to crystal
- Melting Point: 213–217°C (literature 214°C)
- Boiling Point: 366.8±34.0°C at 760 mmHg (predicted)
- Density: 1.836±0.06 g/cm³ (predicted)
- pKa: 3.30±0.10 (predicted)
- Solubility: Soluble in methanol
- Storage: Keep in dark place, inert atmosphere, room temperature (recommended <15°C)
- GHS Classification: Warning; H302 (Harmful if swallowed), H317 (May cause an allergic skin reaction), H319 (Causes serious eye irritation)
- WGK Germany: 3 (high hazard to water)
- HS Code: 2934.20.8000
The compound’s reactivity is defined by its two orthogonal handles: the bromine atom at the 6-position serves as the preferential site for palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), while the primary amine at the 2-position enables acylation, sulfonylation, reductive amination, and imine formation. The 6-position substitution on the benzothiazole ring is a critical determinant of biological activity, physicochemical properties, and synthetic utility. Quantitative structure-activity relationship (QSAR) studies have demonstrated that both the hydrophobic character and molar refractivity of the 6-substituent are key drivers of inhibitory potency against cytochrome P450 enzymes. Consequently, substituting 2-amino-6-bromobenzothiazole with the parent 2-aminobenzothiazole or other 6-substituted analogs (e.g., 6-methyl, 6-methoxy, 6-nitro) is likely to result in significant deviations in target binding, cellular potency, and metabolic stability, thereby compromising research reproducibility and lead optimization efforts.
Major Market Participants
The global supply system for 2-amino-6-bromobenzothiazole (CAS# 15864-32-1) features a pattern of “specialized heterocyclic building block suppliers, multinational chemical distributors, and Chinese manufacturers serving distinct market segments.” As a specialized halogenated heterocyclic building block rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to pharmaceutical R&D, agrochemical development, chemical biology, and academic research.
In the global research and high-purity segment, key international suppliers include Thermo Fisher Scientific (Alfa Aesar/Acros Organics), offering the compound at 95–98% purity; TCI Chemicals, providing >97.0% purity (GC)(T); Sigma-Aldrich (Merck), offering 97% purity; and Santa Cruz Biotechnology, providing research-grade material. Other suppliers include Chem-Impex International, BOC Sciences, AKSci, and Aladdin Scientific. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications, typically at 95–98% purity.
In the industrial and large-scale production segment, Chinese manufacturers have emerged as a dominant force in the global supply chain. XinChem is a reliable manufacturer and supplier of high-purity 2-amino-6-bromobenzothiazole from China, offering the compound at ≥98% purity in packaging sizes ranging from grams to kilograms, with custom synthesis and bulk quantities available upon request. Chinese suppliers are concentrated in major chemical manufacturing regions including Shaanxi, Hubei, Zhejiang, and other industrial provinces, leveraging cost advantages and established supply chains to serve both domestic and international markets. Bulk quantities are available with Certificates of Analysis (COA) confirming purity and identity.
Regional Market Dynamics
The global 2-amino-6-bromobenzothiazole market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, agrochemical, and chemical biology industries in these regions. According to industry research reports, comprehensive data on 2-amino-6-bromobenzothiazole markets is available globally and regionally, with forecasts extending through 2029.
The Asia-Pacific region has emerged as a significant production hub for 2-amino-6-bromobenzothiazole, with China hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing pharmaceutical and agrochemical industries. Chinese suppliers offer the compound at various purity grades (typically 95–98%) and packaging options, serving both domestic and export markets. The growing pharmaceutical R&D, agrochemical, and chemical biology sectors in China, India, Japan, and South Korea continue to drive regional consumption growth.
North America remains a key market for high-purity and research-grade 2-amino-6-bromobenzothiazole, driven by demand from the pharmaceutical industry, biotechnology companies, and academic research institutions. The United States hosts numerous research organizations, pharmaceutical companies, and contract research organizations that require high-quality heterocyclic building blocks for kinase inhibitor discovery, antimicrobial drug development, and chemical biology research. The region’s well-established regulatory framework and emphasis on product quality support demand for high-grade research chemicals and pharmaceutical intermediates.
Europe is characterized by stringent regulatory requirements and a strong focus on quality and sustainability in pharmaceutical and chemical research. European pharmaceutical companies, agrochemical developers, and research institutions demand high-purity heterocyclic building blocks with comprehensive documentation. The region’s strong pharmaceutical and biotechnology sectors support steady demand for halogenated benzothiazole derivatives.
Japan represents a specialized market where 2-amino-6-bromobenzothiazole is supplied by TCI Chemicals and other distributors for pharmaceutical research and chemical biology applications.
Regulatory and Safety Considerations
As a research chemical, pharmaceutical intermediate, and heterocyclic building block, 2-amino-6-bromobenzothiazole (CAS# 15864-32-1) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.
In the United States, 2-amino-6-bromobenzothiazole is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. The compound is not a controlled substance.
In the European Union, the compound must comply with REACH registration requirements for import and use. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation.
GHS classification and handling: 2-Amino-6-bromobenzothiazole is classified with the signal word “Warning”. Hazard statements include H302 (Harmful if swallowed), H317 (May cause an allergic skin reaction), and H319 (Causes serious eye irritation). Precautionary statements include P261 (Avoid breathing dust/fume/gas/mist/vapors/spray), P264 (Wash skin thoroughly after handling), P280 (Wear protective gloves/eye protection/face protection), P301+P312+P330 (IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell; rinse mouth), P302+P352 (IF ON SKIN: Wash with plenty of soap and water), and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing). The compound should be stored in a dark place under inert atmosphere at room temperature (recommended <15°C). The WGK Germany classification is 3 (high hazard to water).
For international transport, 2-amino-6-bromobenzothiazole is classified under HS Code 2934.20.8000. Proper packaging, labeling, and documentation are required for international shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations.
Future Outlook
The market outlook for 2-amino-6-bromobenzothiazole is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized heterocyclic building block, its orthogonal reactivity, privileged benzothiazole scaffold, and versatility position it for steady growth in the coming years.
Key growth drivers include:
- Expansion of targeted kinase inhibitor R&D: The continued development of kinase inhibitors for oncology, inflammation, and autoimmune diseases drives demand for versatile heterocyclic building blocks capable of Suzuki-Miyaura cross-coupling and late-stage functionalization.
- Growth in antimicrobial drug discovery: Increasing global concern over antimicrobial resistance and the need for novel antibacterial and antifungal agents supports demand for privileged scaffolds like 2-amino-6-bromobenzothiazole.
- Expansion of chemical biology and probe development: The growing use of fluorescent probes and bioactive small molecules in life science research drives demand for high-purity heterocyclic building blocks.
- Increasing focus on heterocyclic drug discovery: The benzothiazole scaffold is increasingly recognized as a privileged structure in medicinal chemistry, enhancing target binding affinity and metabolic stability.
- Development of agrochemical actives: The compound’s role in the synthesis of biologically active compounds for crop protection aligns with global trends toward sustainable agriculture.
Challenges and considerations:
- Regulatory compliance: Increasingly stringent pharmaceutical, agrochemical, and chemical regulations may require ongoing investment in quality systems and documentation.
- Competition from alternative building blocks: The market faces competition from other halogenated benzothiazoles and heterocyclic building blocks with similar reactivity profiles.
- Hazardous material handling: The compound’s GHS classification (H302, H317, H319) requires appropriate safety measures during handling and storage.
- Limited scale: As a relatively specialized compound, the market for 2-amino-6-bromobenzothiazole is smaller than that of commodity chemicals.
To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, agrochemical, and chemical biology applications will be well-positioned to capture growing demand.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals and heterocyclic building blocks, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, chemical biology, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 2-Amino-6-bromobenzothiazole (CAS# 15864-32-1) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for research institutions, pharmaceutical companies, and industrial manufacturers seeking this versatile halogenated heterocyclic building block.
1. Technical Advantages
Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2-amino-6-bromobenzothiazole products. The production process incorporates established synthetic routes—including the reaction of 4-bromoaniline with acetic acid and potassium thiocyanate in a solution of bromine in acetic acid, or the monobromination of 2-aminobenzothiazole with silica-supported quinolinium tribromide—enabling the delivery of products with purity ≥98% to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities, and batch-to-batch reproducibility, providing customers with reliable performance in kinase inhibitor synthesis, antimicrobial drug development, and chemical biology research.
Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (GC/HPLC), melting point, and impurity profiles. This commitment to quality ensures that XinChem’s 2-amino-6-bromobenzothiazole meets the stringent requirements of pharmaceutical R&D, agrochemical development, and research applications.
2. Product Advantages
High Purity and Consistent Quality
XinChem offers 2-amino-6-bromobenzothiazole with purity ≥98% (GC/HPLC), ensuring optimal performance in kinase inhibitor discovery, antimicrobial drug development, and chemical biology research. The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery, probe development, and agrochemical research.
Comprehensive Specifications
Key specifications include:
- Molecular Formula: C₇H₅BrN₂S
- Molecular Weight: 229.10 g/mol
- CAS Number: 15864-32-1
- MDL Number: MFCD00152229
- Synonyms: 6-Bromo-1,3-benzothiazol-2-amine; 6-bromobenzothiazol-2-amine; 6-bromo-2-benzothiazolamine
- Appearance: White to light yellow to light orange powder to crystal
- Purity: ≥98% (GC/HPLC)
- Melting Point: 213–217°C
- Storage: Keep in dark place, inert atmosphere, room temperature (recommended <15°C)
Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (grams) to industrial-scale packaging (kilograms) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation.
3. Application Fields
As a versatile halogenated heterocyclic building block, 2-Amino-6-bromobenzothiazole (CAS# 15864-32-1) exhibits wide application value across multiple industries:
Pharmaceutical R&D and Kinase Inhibitor Discovery:
- Key building block for focused kinase inhibitor libraries via Suzuki-Miyaura cross-coupling at the 6-position
- Precursor for PI3Kβ-targeted anti-proliferative agents
- Scaffold for SAR studies through parallel acylation, sulfonylation, and late-stage functionalization
- Building block for biologically active heterocycles and pharmacologically relevant small molecules
Antimicrobial and Antiparasitic Drug Development:
- Key intermediate for antibacterial and antifungal agents
- Core scaffold for anthelmintic medicinal chemistry SAR studies
- Precursor for enzyme inhibitors targeting various biological systems
Chemical Biology and Probe Development:
- Precursor for fluorescent probes for biological process visualization
- Tool for studying enzyme inhibition and receptor interactions
- Molecular scaffold for bioactive compound synthesis
Agrochemical Research:
- Building block for biologically active compounds for crop protection
Industrial Applications:
- Precursor for dyes and specialty chemicals
4. Service Support
Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of Suzuki-Miyaura coupling conditions, guidance on derivatization strategies, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.
Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including customs clearance and documentation.
Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, and other regional regulations, helping customers navigate the complexities of global trade.
5. Reasons to Choose XinChem
- Professionalism: Extensive experience and deep expertise in heterocyclic building block synthesis and supply.
- Quality: Rigorous quality control, high purity (≥98%), and adherence to international standards.
- Reliability: Stable supply, competitive pricing, and timely delivery.
- Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
- Service: Responsive technical support and comprehensive documentation.
Contact us today to start your partnership with XinChem!
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Sep-01-2026