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2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3), also known as 3-bromo-2-chloropyridine or 3-bromo-2-chloropyridine, is a halogenated pyridine derivative with the molecular formula C₅H₃BrClN and a molecular weight of 192.44 g/mol. Its molecular structure features a pyridine ring bearing two distinct halogen substituents: a chlorine atom at the 2-position and a bromine atom at the 3-position. This unique ortho-halogenated substitution pattern—combining a chlorine atom (enabling nucleophilic aromatic substitution) and a bromine atom (preferential site for palladium-catalyzed cross-coupling)—confers exceptional orthogonal reactivity for sequential functionalization without the need for protecting group chemistry. The compound typically appears as a white to light yellow to light orange crystalline powder with a melting point of 55–59°C and a boiling point of 97°C at 10 mmHg. It is soluble in common organic solvents such as alcohol, ether, and chlorinated hydrocarbons, but insoluble in water at room temperature. The compound is typically supplied at ≥98% purity and should be stored in a cool, dark place below 15°C.

This orthogonally reactive halogenated pyridine has emerged as a versatile building block in pharmaceutical R&D—particularly in the synthesis of γ-secretase modulators for Alzheimer’s disease and other neurological disorder therapeutics—as well as in agrochemical development, OLED materials, and specialty polymers. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regulatory landscape, and future outlook of this strategically important halogenated heterocyclic building block.

Core Application Fields and Demand

Market demand for 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) is concentrated in three primary sectors: pharmaceutical R&D and drug discovery (approximately 45–50% of global consumption), agrochemical development (approximately 25–30%), and OLED materials, specialty polymers, and research applications (approximately 20–25%). Its orthogonal halogen reactivity and privileged pyridine scaffold serve as the core drivers of sustained demand growth.

In pharmaceutical R&D and drug discovery, 2-Chloro-3-Bromo Pyridine is a critical building block for the synthesis of γ-secretase modulators—a class of compounds that lower Aβ42 in the brain and avoid P-glycoprotein-mediated efflux, making them promising candidates for Alzheimer’s disease therapy. The compound has been specifically cited in patent literature for the preparation of dihydrobenzofuran amides as γ-secretase modulators, and for Malt1 inhibitors, MYT1 inhibitors, and monoacylglycerol lipase (MAGL) inhibitors for cancer and inflammatory disease therapy. The pyridine scaffold bearing orthogonal halogens enables the construction of complex drug-like molecules with high synthetic efficiency. The compound serves as a key intermediate in the synthesis of pharmaceutical agents targeting neurological disorders, and its derivatives are employed in biological research, particularly in studies related to enzyme inhibition and receptor binding, aiding in drug discovery processes.

In agrochemical development, 2-Chloro-3-Bromo Pyridine is used as an important intermediate in the development of agrochemicals, including herbicides and fungicides, enhancing crop protection and yield. The compound’s orthogonal reactivity allows for the introduction of diverse substituents into agrochemical active ingredients, optimizing their efficacy and selectivity.

In OLED and materials science, 2-Chloro-3-Bromo Pyridine has demonstrated significant potential as a key component in the emission layer or charge transport layer of organic light-emitting diodes (OLEDs), effectively improving device luminous efficiency and lifetime. Its conjugated system and molecular energy level structure are well-suited for optoelectronic applications, with strong absorption and emission characteristics in the visible region. The compound’s coordination properties make it valuable for constructing functional material systems, and it exhibits catalytic activity in specific reactions as a homogeneous catalyst for redox processes. It also finds applications in creating specialized polymers and materials, contributing to advancements in coatings and adhesives.

In research and analytical chemistry, 2-Chloro-3-Bromo Pyridine is a versatile reagent employed in organic synthesis and chemical research, facilitating the development of new compounds. It is also used as a research reagent in biological studies related to enzyme inhibition and receptor binding.

Key Properties and Reactivity Profile

2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) is a dihalogenated pyridine whose value derives from the orthogonal reactivity of its two halogen substituents.

Key physicochemical parameters include:

Molecular Formula: C₅H₃BrClN
Molecular Weight: 192.44 g/mol
CAS Number: 52200-48-3
MDL Number: MFCD00234007
Appearance: White to light yellow to light orange powder to crystal
Purity: ≥98.0% (GC) / ≥99% (HPLC) available
Melting Point: 55.0–59.0°C (literature 57°C)
Boiling Point: 97°C at 10 mmHg
Density: 1.736 g/cm³
LogP: 2.49750
Topological Polar Surface Area: 12.9 Å²
SMILES: C1=CC(=C(N=C1)Cl)Br
InChIKey: HDYNIWBNWMFBDO-UHFFFAOYSA-N
Storage: Room temperature (recommended in a cool and dark place, <15°C) or 0–8°C for long-term storage
GHS Classification: Warning; H315 (Causes skin irritation), H319 (Causes serious eye irritation), H341 (Suspected of causing genetic defects)
H.S. Code: 2933.39-000 (Japan export)

The compound’s orthogonal reactivity is its defining feature: the bromine atom at C3 serves as the preferential site for palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), while the chlorine at C2 enables subsequent nucleophilic aromatic substitution (SNAr) or a second, differentiated cross-coupling reaction—delivering single-isomer products in high yield. The orthogonal arrangement of the two halogens enables sequential, selective functionalization that is otherwise difficult to achieve with symmetric dihalopyridines. The pyridine nitrogen provides a site for coordination and can modulate the electronic properties of the ring.

Major Market Participants

The global supply system for 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) features a pattern of “specialized research chemical suppliers, multinational chemical distributors, and Chinese manufacturers serving distinct market segments.” As a specialized halogenated heterocyclic building block rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to pharmaceutical R&D, agrochemical development, and materials science applications.

In the global research and high-purity segment, key international suppliers include Tokyo Chemical Industry (TCI), offering the compound at >98.0% (GC) purity with product code B2328, available in 5 g and 25 g quantities at competitive pricing; Chem-Impex International, offering ≥99% (HPLC) purity with 250 g packaging options; Thermo Fisher Scientific (Acros Organics), offering 97% and 98% purity grades; BOC Sciences, providing the compound as a building block with over 20,000 intermediates available from stock and process scale-up capabilities from lab to industrial scale; AKSci, offering the compound from its San Francisco facility; and CymitQuimica, offering the compound through its distribution network. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications.

In the industrial and large-scale production segment, Chinese manufacturers have emerged as significant players in the global supply chain. XinChem is a reliable manufacturer and supplier of high-purity 2-Chloro-3-Bromo Pyridine from China, offering the compound with stringent quality standards for use in pharmaceutical synthesis, agrochemical development, and OLED materials research. XinChem offers the compound as a white crystalline solid with comprehensive quality documentation and flexible packaging options. Other Chinese suppliers are concentrated in major chemical manufacturing regions including Shaanxi, Hubei, Jiangsu, and Shanghai. Chinese suppliers offer the compound at various purity grades (typically 98–99%) and packaging options—from grams to multi-kilogram quantities—serving both domestic and export markets with competitive pricing. Production scale capabilities include up to 500 kg quantities.

Regional Market Dynamics

The global 2-Chloro-3-Bromo Pyridine market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, agrochemical, and materials science industries in these regions. Comprehensive industry research on 3-Bromo-2-chloropyridine is available covering global and regional market trends from 2019–2024 with forecasts extending to 2029, including detailed price analysis.

The Asia-Pacific region has emerged as a significant production hub for 2-Chloro-3-Bromo Pyridine, with China hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing pharmaceutical, agrochemical, and electronics industries. Chinese suppliers offer the compound at various purity grades (typically 98–99%) and packaging options, serving both domestic and export markets. The growing pharmaceutical R&D, agrochemical, and OLED sectors in China, Japan, South Korea, and India continue to drive regional consumption growth. TCI Chemicals maintains inventory in Japan and China, with the ability to ship from Shanghai and Tianjin warehouses.

North America remains a key market for high-purity and research-grade 2-Chloro-3-Bromo Pyridine, driven by demand from the pharmaceutical industry, biotechnology companies, and academic research institutions. The United States hosts numerous research organizations, pharmaceutical companies, and contract research organizations that require high-quality heterocyclic building blocks for drug discovery and development. TCI America, Chem-Impex International, and BOC Sciences serve the North American market with extensive distribution networks. The region’s well-established regulatory framework and emphasis on product quality support demand for high-grade research chemicals and pharmaceutical intermediates.

Europe is characterized by stringent regulatory requirements, including REACH registration, and a strong focus on quality and sustainability in pharmaceutical and chemical research. European pharmaceutical companies, agrochemical developers, and research institutions demand high-purity heterocyclic building blocks with comprehensive documentation. TCI Deutschland GmbH, Fluorochem, and other distributors serve the European market with in-stock availability.

Japan represents a specialized market where 2-Chloro-3-Bromo Pyridine is supplied by TCI Chemicals and other distributors for pharmaceutical research, agrochemical development, and OLED materials applications.

Regulatory and Safety Considerations

As a research chemical, pharmaceutical intermediate, and agrochemical building block, 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.

GHS classification and handling: 2-Chloro-3-Bromo Pyridine is classified with the signal word ”Warning”. Hazard statements include H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H341 (Suspected of causing genetic defects). Precautionary statements include P501 (Dispose of contents/container to an approved waste disposal plant), P202 (Do not handle until all safety precautions have been read and understood), P201 (Obtain special instructions before use), P264 (Wash skin thoroughly after handling), P280 (Wear protective gloves/protective clothing/eye protection/face protection), P302+P352 (IF ON SKIN: Wash with plenty of water), P308+P313 (IF exposed or concerned: Get medical advice/attention), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing), and P405 (Store locked up). The WGK Germany classification is 3 (high hazard to water). The compound is classified as a combustible solid and should be stored in a cool, dry place away from oxidizing agents.

Storage and stability: 2-Chloro-3-Bromo Pyridine should be stored in a cool, dark place below 15°C for short-term storage or at 0–8°C for long-term storage. Contact with moisture should be avoided, and the compound should be kept away from strong oxidizing agents.

Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements for import and use. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, 2-Chloro-3-Bromo Pyridine is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. For pharmaceutical intermediate applications, manufacturers must comply with relevant FDA regulations and quality standards.

Transport information: 2-Chloro-3-Bromo Pyridine is not classified as hazardous material for DOT/IATA transport purposes. Proper packaging, labeling, and documentation are nevertheless required for international shipping in compliance with the International Maritime Dangerous Goods Code (IMDG Code) and other transport regulations. The H.S. code for the compound is 2933.39-000 for Japan exports.

Future Outlook

The market outlook for 2-Chloro-3-Bromo Pyridine is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized heterocyclic building block, its orthogonal halogen reactivity and versatility position it for steady growth in the coming years.

Key growth drivers include:

Expansion of neurological drug discovery: The continued development of γ-secretase modulators for Alzheimer’s disease and other neurological disorder therapeutics drives demand for this key precursor. The compound’s documented use in the synthesis of dihydrobenzofuran amides that lower Aβ42 in the brain positions it at the forefront of Alzheimer’s research.
Growth in targeted cancer therapy R&D: The compound’s role as a building block for Malt1 inhibitors and MYT1 inhibitors for cancer therapy supports demand from oncology drug discovery programs.
Expansion of agrochemical development: The growing global demand for novel herbicides and fungicides drives consumption of the compound as a precursor for crop protection agents.
Growth in OLED and display technologies: The expanding market for high-efficiency, low-power OLED displays creates new opportunities for the compound in materials science. Its role as a key component in OLED emission and charge transport layers positions it for growth.
Increasing focus on orthogonal synthesis: The compound’s ability to enable sequential functionalization without protecting groups makes it increasingly valuable in modern synthetic chemistry for constructing complex drug-like molecules efficiently.
Growth in research and analytical applications: The compound’s utility as a research reagent in enzyme inhibition and receptor binding studies supports demand from academic and industrial research laboratories.

Challenges and considerations:

Regulatory compliance: Increasingly stringent pharmaceutical, agrochemical, and chemical regulations may require ongoing investment in quality systems and documentation.
Hazardous material handling: The compound’s classification with H341 (Suspected of causing genetic defects) requires appropriate safety measures during handling and storage.
Competition from alternative building blocks: The market faces competition from other halogenated pyridines and heterocyclic building blocks with similar reactivity profiles.
Limited scale: As a relatively specialized compound, the market for 2-Chloro-3-Bromo Pyridine is smaller than that of commodity chemicals.

To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, agrochemical, and materials science applications will be well-positioned to capture growing demand.

Shanghai XinChem Co., Ltd. (XinChem)

As a world-leading supplier of organic chemicals and heterocyclic building blocks, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, materials science, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for research institutions, pharmaceutical companies, and industrial manufacturers seeking this versatile orthogonally reactive halogenated pyridine building block.

1. Technical Advantages

Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2-Chloro-3-Bromo Pyridine products. The production process incorporates established synthetic routes—including the selective halogenation of pyridine derivatives—enabling the delivery of products with purity ≥98% (GC) to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities, and batch-to-batch reproducibility, providing customers with reliable performance in pharmaceutical synthesis, agrochemical development, and materials science applications.

Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (GC/HPLC), melting point, and impurity profiles. This commitment to quality ensures that XinChem’s 2-Chloro-3-Bromo Pyridine meets the stringent requirements of pharmaceutical R&D, agrochemical development, and materials science applications.

2. Product Advantages

High Purity and Consistent Quality
XinChem offers 2-Chloro-3-Bromo Pyridine with purity ≥98% (GC) and ≥99% (HPLC) available, ensuring optimal performance in pharmaceutical synthesis, agrochemical development, and materials science applications. The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in drug discovery, crop protection, and OLED materials.

Comprehensive Specifications
Key specifications include:

Molecular Formula: C₅H₃BrClN
Molecular Weight: 192.44 g/mol
CAS Number: 52200-48-3
Synonyms: 3-Bromo-2-chloropyridine
MDL Number: MFCD00234007
Appearance: White to light yellow to light orange powder to crystal
Purity: ≥98.0% (GC) / ≥99% (HPLC) available
Melting Point: 55.0–59.0°C
Boiling Point: 97°C at 10 mmHg
Storage: Room temperature (recommended in a cool and dark place, <15°C) or 0–8°C for long-term storage

Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (1 g, 5 g, 10 g, 25 g) to industrial-scale packaging (100 g, 250 g, 500 g, 1 kg) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation.

3. Application Fields

As a versatile orthogonally reactive halogenated pyridine building block, 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3) exhibits wide application value across multiple industries:

Pharmaceutical R&D and Drug Discovery:

Key building block for γ-secretase modulators for Alzheimer’s disease therapy (dihydrobenzofuran amides that lower Aβ42 in the brain)
Precursor for Malt1 inhibitors, MYT1 inhibitors, and monoacylglycerol lipase (MAGL) inhibitors for cancer and inflammatory disease therapy
Intermediate for pharmaceutical agents targeting neurological disorders
Building block for enzyme inhibition and receptor binding studies

Agrochemical Development:

Key intermediate for herbicides and fungicides
Precursor for crop protection agents with improved efficacy and selectivity

OLED and Materials Science:

Key component in OLED emission layer or charge transport layer
Building block for specialized polymers and materials
Precursor for functional materials with strong visible absorption and emission characteristics
Component in coatings and adhesives

Research and Analytical Applications:

Versatile reagent for organic synthesis and chemical research
Building block for developing new compounds
Research reagent for biological studies

4. Service Support

Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of cross-coupling reaction conditions, guidance on orthogonal functionalization strategies, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.

Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including customs clearance and documentation, with appropriate temperature control for product stability.

Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, and other regional regulations, helping customers navigate the complexities of global trade.

5. Reasons to Choose XinChem

Professionalism: Extensive experience and deep expertise in heterocyclic building block synthesis and supply.
Quality: Rigorous quality control, high purity (≥98% to ≥99%), and adherence to international standards.
Reliability: Stable supply, competitive pricing, and timely delivery.
Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
Service: Responsive technical support and comprehensive documentation.

Website: www.xinchem.com

Email: sales1@xinchem.com

WhatsApp: +86 18049800532

Post time: Sep-13-2026

The Orthogonally Reactive Halogenated Pyridine Building Block for Neurological Drug Discovery, Agrochemicals, and OLED Materials: 2-Chloro-3-Bromo Pyridine (CAS# 52200-48-3)