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2-Amino-6-bromothiazolo[5,4-b]pyridine(CAS#1160791-13-8)
Introduction
2-Amino-6-bromothiazole[5,4-b]pyridine is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:- Appearance: White to pale yellow crystalline solid.- Soluble: Soluble in some organic solvents, such as methanol and methylene chloride.- Chemical reactions: Cyclization reactions can occur under the action of strong alkalis.Use:- 2-Amino-6-bromothiazole[5,4-b]pyridine is an important intermediate compound that can be used in the synthesis of other compounds.- It is used in agriculture as an intermediate for pesticides such as pesticides, fungicides, etc.Method:- 2-Amino-6-bromothiazole[5,4-b]pyridine can be prepared by a variety of synthetic methods, the most commonly used of which is obtained by the reaction of aminothiazole and bromopyridine.Safety Information:- 2-Amino-6-bromothiazole[5,4-b]pyridine is an organic compound that requires careful handling.- Operate in a well-ventilated area and take appropriate protective measures, such as wearing gloves, protective eyewear and protective clothing.- In case of accidental contact or inhalation, immediately move away from the scene and wash the affected area, and seek medical attention promptly if symptoms persist or worsen.
Application
2-Amino-6-bromothiazolo[5,4-b]pyridine (CAS 1160791-13-8) is a privileged heterocyclic scaffold featuring a thiazole ring fused with a pyridine core, bearing a reactive bromine at the 6‑position and a free amino group at the 2‑position. This advanced building block is widely utilized in medicinal chemistry for the synthesis of potent and selective tyrosine kinase inhibitors targeting EGFR‑TK, PI3K, c‑KIT, Bcr‑Abl, and VEGFR2, with demonstrated anticancer activity against non‑small cell lung cancer (NSCLC), gastrointestinal stromal tumors (GIST), and chronic myelogenous leukemia (CML). The bromine atom enables efficient Suzuki‑Miyaura, Buchwald‑Hartwig, and Sonogashira cross‑coupling reactions for rapid structure‑activity relationship (SAR) studies, while the amino group facilitates amide, sulfonamide, and urea formation. Its derivatives have shown nanomolar IC₅₀ values against resistant cancer cell lines (e.g., HCC827, H1975, GIST‑T1) with selectivity over normal cells, and have been explored as chemical biology probes for signal transduction research. Additionally, this scaffold is employed in the synthesis of antimicrobial agents, agrochemicals (herbicides, fungicides), and advanced functional materials including organic semiconductors and fluorescent dyes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high‑purity building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
