2-bromo-5-methylbenzoic acid(CAS#6967-82-4)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Class | IRRITANT |
Introduction
2-bromo-5-methylbenzoic acid, chemical formula C8H7BrO2, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-bromo-5-methylbenzoic acid is a white crystalline solid.
-Melting point: about 167-168 degrees Celsius.
-Stability: Stable at room temperature, but sensitive to light and heat.
Use:
-Chemical reagent: 2-bromo-5-methylbenzoic acid is often used as an intermediate in organic synthesis reactions to synthesize other organic compounds.
-Drugs: It is also used as a raw material in the pharmaceutical industry for the synthesis of certain drugs.
Preparation Method:
- 2-bromo-5-methylbenzoic acid can be prepared by bromination of benzoic acid. Benzoic acid is first reacted with bromine in the presence of ferrous chloride, followed by methylation.
Safety Information:
- 2-bromo-5-methylbenzoic acid has limited safety information, so you must be cautious when using and operating it.
-It is a corrosive substance that may cause irritation and damage to the eyes, skin and respiratory tract. Therefore, appropriate personal protective equipment such as chemical protective gloves, safety glasses and protective face masks should be worn during operation.
-When storing, it should be kept in a dry and ventilated place to avoid contact with oxidants and strong acids.
-During the treatment process, please follow the correct disposal methods of chemicals to prevent environmental pollution and harm.
Application
2-Bromo-5-methylbenzoic acid is a versatile brominated aromatic building block widely used in medicinal chemistry and organic synthesis. The bromine at the 2-position enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl groups, while the carboxylic acid allows amidation or esterification for rapid derivatization. This intermediate serves as a key precursor for biaryl-containing drug candidates, including kinase inhibitors (e.g., EGFR, BTK, CDK), anti-inflammatory agents, and antimicrobial compounds. It is also utilized in agrochemical research for developing herbicides and fungicides. Its rigid aromatic core enhances metabolic stability and target binding affinity, facilitating structure-activity relationship (SAR) studies and library construction. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
