3-Aminohomopiperidine(CAS#69154-03-6)

3-Aminohomopiperidine is an organic compound with the chemical formula C7H15N2. It is a liquid with a colorless to yellowish appearance with a distinctive amino and piperidine group.3-Aminohomopiperidine has a wide range of uses in the field of pharmaceutical and chemical synthesis. It can be used as an intermediate for certain drugs, such as antidepressants and antiepileptic drugs, etc. In addition, it can also be used to synthesize other organic compounds, such as heterocyclic compounds and polymers.

The common method for preparing 3-Aminohomopiperidine is through the amination reaction of homopiperidine. The high piperidine can be condensed with hydrocyanic acid to form a phosphonium salt, followed by dehydration and reduction by heating to finally give 3-Aminohomopiperidine.

With regard to safety information, 3-Aminohomopiperidine needs to be handled with caution. It may be irritating to the eyes, skin and respiratory system. Prolonged exposure to the substance should be avoided and appropriate safety precautions should be taken during handling, such as wearing chemical lab gloves, goggles and protective clothing. When using or handling the substance, the relevant safety procedures should be strictly observed.

Application
3-Aminohomopiperidine (Azepan-3-amine, CAS 69154-03-6) is a valuable nitrogen-containing heterocyclic building block featuring a seven-membered homopiperidine (azepane) ring. As a key pharmaceutical intermediate, it is utilized in the synthesis of N-alkylated pyrimidinediones and serves as a critical precursor for the antidepressant drug Mirtazapine. Its derivatives are extensively investigated as selective GlyT1 inhibitors for the treatment of schizophrenia and have demonstrated significant antiproliferative activity against HepG-2 (liver) and MCF-7 (breast) cancer cell lines with IC50 values ranging from 2.03 to 13.39 µg/mL. This versatile scaffold is also employed in constructing ligands for coordination chemistry and molecular probes for bioimaging. Xinchem offers high-purity 3-Aminohomopiperidine with flexible custom synthesis and contract manufacturing services, scaled reliably from R&D to commercial tons. Contact us for a competitive quote.