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5-(4-Bromophenyl)-4,6-dichloropyrimidine(CAS#146533-41-7)

Chemical Property:

Molecular Formula C10H5BrCl2N2
Molar Mass 303.97
Density 1.677±0.06 g/cm3(Predicted)
Melting Point 98.0 to 102.0 °C
Boling Point 368.7±42.0 °C(Predicted)
Solubility Chloroform (Slightly), DMSO (Slightly)
Appearance Solid
Color Off-White
pKa -4.92±0.26(Predicted)
Storage Condition under inert gas (nitrogen or Argon) at 2-8°C
Use Use 1. The intermediate of masitiptan is a reactant for the synthesis of mateptan, which is an orally active dual endothelin receptor antagonist. 2. The intermediate of masietiptan is mainly used as an intermediate for preparing masietiptan.

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Introduction

5-(4-bromophenyl)-4,6-dichloropyrimidine is an organic compound.Properties: 5-(4-bromophenyl)-4,6-dichloropyrimidine is a solid compound with a white crystalline appearance. It has low solubility at room temperature.Uses: This compound is commonly used as an intermediate in pesticides.Preparation: The method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine involves first synthesizing 4-bromophenyl-5-chloro-1-methylpyrimidine, then using copper cyanide as a catalyst to perform a nucleophilic substitution reaction, replacing the chlorine atom on the pyrimidine ring with a bromine atom through zinc treatment.Safety Information: This compound is an organobromide and should be handled with care. When using it, wear chemical-resistant gloves, goggles, and protective clothing. Avoid skin contact, inhalation, or ingestion. In the presence of a fire source, harmful gases may be produced. Ensure good ventilation during handling and storage.


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