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4-Amino-2-methylbenzoic acid methyl ester(CAS#6933-47-7)

Chemical Property:

Molecular Formula C9H11NO2
Molar Mass 165.19
Density 1.132±0.06 g/cm3(Predicted)
Boling Point 302.4±22.0 °C(Predicted)
Flash Point 157.5°C
Vapor Presure 0.001mmHg at 25°C
pKa 2.59±0.10(Predicted)
Storage Condition under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index 1.559

Product Detail

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Introduction

4-Amino-2-methylbenzoic acid methyl ester is an organic compound with the chemical formula C9H11NO2. The following is a description of its nature, use, preparation and safety information:

 

Nature:

-Appearance: 4-Amino-2-methylbenzoic acid methyl ester is white crystalline powder.

-Solubility: Soluble in organic solvents such as ethanol, ether, etc.

-Melting point: approximately 92-95°C.

-Ignition point: about 244°C.

-Toxicity: No clear toxicity information is available.

 

Use:

4-Amino-2-methylbenzoic acid methyl ester is commonly used in the field of organic synthesis as an intermediate or starting material. It can participate in various reactions for the synthesis of other compounds, such as drugs, dyes, coatings, etc.

 

Preparation Method:

The preparation of 4-Amino-2-methylbenzoic acid methyl ester can be carried out by the following steps:

1.4-amino -2-methyl benzoic acid (4-Amino-2-methylbenzoic acid) and formic anhydride (methyl formate) reaction under appropriate conditions.

2. After the reaction, the target product can be obtained through appropriate purification steps (such as crystallization, extraction, etc.).

 

Safety Information:

Due to the lack of specific toxicity information, when using 4-Amino-2-methylbenzoic acid methyl ester, it is necessary to take appropriate laboratory safety measures to avoid contact with skin, eyes and respiratory tract. At the same time, you should operate in a well-ventilated environment and wear appropriate personal protective equipment, including laboratory gloves, eye protection and protective masks. In case of accidental contact or inhalation, rinse immediately with clean water and seek medical help.

Application
Methyl 4-amino-2-methylbenzoate (CAS 6933-47-7) is a functionalized benzoic acid derivative bearing an amino group and a methyl ester. This high-purity organic intermediate is widely used in pharmaceutical and agrochemical research. The aromatic amine enables amide coupling, heterocycle formation (e.g., benzimidazoles, quinazolines), and diazotization reactions, while the methyl ester allows selective saponification or transesterification. This building block serves as a key precursor for the synthesis of angiotensin II receptor antagonists (e.g., losartan analogs), antimicrobial agents, and anti-inflammatory drug candidates. It is also employed in the preparation of dyes, pigments, and functional polymers. Its rigid, electron-rich aromatic core enhances metabolic stability and target binding. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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