2-methyl-4-aminobenzoic acid(CAS#2486-75-1)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29224999 |
Introduction
2-methyl-4-aminobenzoic acid is an organic compound with the chemical formula C9H9NO2.
Nature:
-Appearance: 2-methyll-4-aminobenzoic acid is white crystalline powder.
-Solubility: It can be dissolved in hot water, but also soluble in chloroform, ethanol and ether and other organic solvents.
-Melting point: Its melting point is 197-199 ° C.
Use:
-2-methyll-4-aminobenzoic acid is widely used in the field of medicine and is often used as a drug intermediate.
-It can also be used as an ingredient in dyes, photosensitizers and cosmetics.
-In organic synthesis, it can be used as additives such as preservatives, antioxidants and anti-ultraviolet agents.
Method:
- 2-methyl-4-aminobenzoic acid can be prepared by reacting p-methyl-substituted benzoic acid with amino compounds.
-The reaction is generally carried out under appropriate reaction conditions, and the product is purified by crystallization and purification steps.
Safety Information:
-2-methyll-4-aminobenzoic acid has low toxicity, but care should still be taken to avoid inhalation and skin contact.
-Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during use or handling.
-It should be stored in a dry, well-ventilated place, away from fire and combustibles.
Application
2-Methyl-4-aminobenzoic acid (4-Amino-2-methylbenzoic acid, CAS 2486-75-1) is a multifunctional aromatic building block serving as a key pharmaceutical intermediate and research chemical. Its primary application lies in the synthesis of tolvaptan, a vasopressin V2 receptor antagonist used to treat hyponatremia. As Tolvaptan Impurity 33, it serves as a critical reference standard for analytical method development, method validation (AMV), quality control (QC), and ANDA filings. Beyond pharmaceuticals, this versatile compound is utilized as an intermediate in the production of dyes, photosensitizers, and cosmetic formulations. In organic synthesis, it functions as an additive with antioxidant and UV-absorbing properties. Its amino and carboxylic acid groups enable diverse derivatizations including amide coupling and diazotization, supporting structure-activity relationship (SAR) studies and the construction of drug-like libraries targeting oncology, inflammation, and infectious diseases. Xinchem offers reliable custom synthesis and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote.
