Methyl 3-amino-4-methylbenzoate(CAS#18595-18-1)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29224999 |
| Hazard Note | Irritant |
Introduction
Methyl 3-amino-4-methylbenzoate, also known as methyl p-toluben. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:Methyl 3-amino-4-methylbenzoate is an organic compound that is a colorless or yellowish liquid. It has an aromatic flavor at room temperature.Use:Methyl 3-amino-4-methylbenzoate has a wide range of uses in the chemical field. It can also be used as a solvent and additive in products such as coatings, glues, and plastics.Method:A common method for the preparation of methyl 3-amino-4-methylbenzoate is obtained by reacting methylbenzoic acid with methylamine. The specific step is to dissolve p-tolusic acid and methylamine in an organic solvent, add a reaction catalyst (such as ammonium chloride), and carry out a heating reaction. After the reaction is completed, the target product is purified by distillation.Safety Information:Methyl 3-amino-4-methylbenzoate is relatively safe when used and stored correctly. It is an organic compound that has a certain toxicity. Exposure to or inhalation of excessive amounts of methyl 3-amino-4-methylbenzoate can be a health hazard, such as irritation of the eyes, skin, and respiratory tract. When using this compound, appropriate protective measures such as gloves, goggles, and protective masks should be worn to avoid direct contact and inhalation. In addition, it should be operated in a well-ventilated place to avoid generating a large amount of volatile gases. In case of accidental contact or inhalation, it should be washed or treated with medical attention promptly.
Application
Methyl 3-amino-4-methylbenzoate (CAS 18595-18-1) is a multifunctional aromatic building block featuring an amino group and a methyl ester on a methyl-substituted benzene ring. It serves as a key pharmaceutical intermediate in the synthesis of bioactive molecules, including local anesthetics (benzocaine analogs), anti-inflammatory agents, and antimicrobial compounds. The amino group enables amide coupling, diazotization, and heterocycle formation (e.g., benzimidazoles, quinazolines), while the methyl ester provides a versatile handle for hydrolysis or transesterification. This scaffold is also utilized in agrochemical research for the preparation of herbicides and fungicides, as well as in the synthesis of dyes, pigments, and functional polymers. Its rigid aromatic core enhances metabolic stability and target binding. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
