From Laboratory Development to Commercial Manufacturing
XinChem provides integrated process development, scale-up and commercial manufacturing support for pharmaceutical intermediates, advanced building blocks and specialty chemicals.
Our capabilities cover the full development cycle — from laboratory route evaluation and process optimization to pilot production and recurring commercial-scale manufacturing.
With 100+ production reactors ranging from approximately 500 L to 10,000 L, combined with laboratory and pilot-scale equipment, we support projects from early-stage development to kilogram, ton and multi-ton production.
Flexible Scale-Up Platform
Integrated development and manufacturing capabilities from milliliter-scale chemistry to commercial production.
Laboratory Development
- Route scouting and feasibility studies
- Reaction condition screening
- Process optimization
- Raw material evaluation
- Impurity identification and control
- Sample preparation
- Process reproducibility studies
- Analytical method support
Kilo Lab & Pilot Production
- Kilogram-scale preparation
- Process scale-up verification
- Engineering batches
- Reaction parameter optimization
- Work-up and purification optimization
- Process safety evaluation
- Impurity profile confirmation
- Technology transfer preparation
Commercial Manufacturing
XinChem’s manufacturing network is equipped with more than 100 commercial production reactors, allowing flexible production planning according to chemistry, batch size and customer demand.
- Kilogram-to-ton scale production
- Multi-ton commercial campaigns
- Regular repeat production
- Multi-step synthesis
- Dedicated customer projects
- Custom manufacturing
- Technology transfer
- Process optimization
Core Reaction Technologies
Broad synthetic chemistry capabilities supporting custom synthesis, route development, scale-up and commercial manufacturing.
Fluorination & Fluorinated Chemistry
Fluorinated aromatic and heterocyclic intermediates for pharmaceuticals, agrochemicals and advanced materials.
Bromination & Chlorination
Selective halogenation and preparation of functionalized intermediates for downstream transformations.
Catalytic Hydrogenation
Hydrogenation, hydrogenolysis and selected functional-group reductions for pharmaceutical and specialty chemical intermediates.
Chemical Reduction
Selective reduction routes optimized for product quality, process safety and scale-up feasibility.
Grignard Reactions
Carbon-carbon bond formation using alkyl, aryl and vinyl Grignard chemistry.
Cross-Coupling Reactions
Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, Heck, Negishi and selected Ullmann-type chemistry.
Amination & Reductive Amination
Preparation of amine-containing intermediates through nucleophilic and reductive amination routes.
Nitration Chemistry
Nitration routes integrated with downstream reduction or hydrogenation to amino intermediates.
Heterocycle Synthesis & Cyclization
Development and manufacture of pyridine, pyrimidine, piperidine, piperazine, indole, azaindole and other heterocyclic intermediates.
Amidation & Esterification
Amide and ester formation for pharmaceutical intermediates, amino acid derivatives and specialty chemicals.
Diazotization Chemistry
Controlled diazotization for downstream functionalization of aromatic amines.
Oxidation & Condensation
Selected oxidation and carbon-carbon / carbon-nitrogen bond-forming condensation chemistry.
Protection & Deprotection
Boc, Cbz, Fmoc, benzyl and acetal/ketal protection strategies in multi-step synthesis.
Chiral & Multi-Step Synthesis
Customer-specific route development, intermediate isolation, impurity control and commercial scale-up.
From 50 mL to 10,000 L
| Typical Scale | Development Stage |
|---|---|
| 50 mL–500 mL | Reaction screening and route evaluation |
| 0.5–5 L | Laboratory process optimization |
| 5–20 L | Scale-up verification |
| 20–100 L | Kilo-lab and pilot production |
| 500–1,000 L | Initial commercial production |
| 2,000–5,000 L | Regular ton-scale manufacturing |
| 10,000 L | Large-scale commercial production |
More Than a Chemical Supplier
XinChem works as an international sales, technical coordination and manufacturing partner for customers in Europe, North America and other global markets.
Looking for a Manufacturing Partner?
Whether you require a specific intermediate, a multi-step custom synthesis project or commercial-scale manufacturing, our team can evaluate your chemistry and production requirements.
Please provide the product name, CAS number or chemical structure, required specification, target quantity, current development stage and available synthetic route, if applicable.
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Contact XinChem for Custom Synthesis & Contract Manufacturing