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The Trifunctional Thiazole Building Block That Lets Kinase Inhibitor Programs Separate Potency from Selectivity:5-Bromo-4-isopropylthiazol-2-amine (CAS 1025700-49-5)
5-Bromo-4-isopropylthiazol-2-amine (CAS 1025700-49-5), also named 2-amino-5-bromo-4-isopropylthiazole or 5-bromo-4-(propan-2-yl)-1,3-thiazol-2-amine, is a trifunctionalized aminothiazole building block with the molecular formula C₆H₉BrN₂S and a molecular weight of 221.12 g/mol. It presents as a w...Read more -
The Small Oxazole Acid That Decides Whether a Kinase Inhibitor or Antibacterial Lead Has a Scaffold to Build On:5-Methyl-1,3-oxazole-4-carboxylic Acid (CAS 103879-58-9)
5-Methyl-1,3-oxazole-4-carboxylic acid (CAS 103879-58-9), also named 5-methyloxazole-4-carboxylic acid, is a compact heterocyclic carboxylic acid with the molecular formula C₅H₅NO₃ and a molecular weight of only 127.10 g/mol. It presents as a light yellow powder, carries a methyl group at the 5-p...Read more -
The Regioselective Building Block That Makes Ceritinib and Next-Generation Kinase Inhibitors Synthetically Feasible: 2,4,5-Trichloropyrimidine (CAS 5750-76-5)
2,4,5-Trichloropyrimidine (CAS 5750-76-5), also known as 2,4,5-trichloro-1,3-diazine, is a halogenated heterocyclic building block with the molecular formula C₄HCl₃N₂ and a molecular weight of 183.42 g/mol. It presents as a colourless to pale yellow clear liquid with a density of approximately 1....Read more -
The Privileged Aminothiazole Building Block That Gives Medicinal Chemists Two Handles on One Metabolically Stable Scaffold: 2-Amino-5-thiazolemethanol (CAS 131184-73-1)
2-Amino-5-thiazolemethanol (CAS 131184-73-1), also named (2-amino-1,3-thiazol-5-yl)methanol or 2-amino-5-(hydroxymethyl)thiazole, is a compact heterocyclic building block with the molecular formula C₄H₆N₂OS and a molecular weight of only 130.17 g/mol. It presents as a yellow to off-white solid wi...Read more -
The Smallest Aminated Isoxazole That Decides Whether a JAK3 or HIV Protease Program Has a Scaffold to Build On: 4-Aminoisoxazole (CAS 108511-97-3)
4-Aminoisoxazole (CAS 108511-97-3, also 1,2-oxazol-4-amine or isoxazol-4-amine) is the simplest aminated isoxazole: a five-membered ring bearing a primary amine at the 4-position, with the molecular formula C₃H₄N₂O and a molecular weight of only 84.08 g/mol. That small size is the molecule’s comm...Read more -
The Quinoline Building Block That Lets Medicinal Chemists Separate Kinase Selectivity from Kinase Potency:4-Bromoquinolin-6-Amine (CAS 1260785-25-8)
4-Bromoquinolin-6-amine (CAS 1260785-25-8), also named 6-amino-4-bromoquinoline, is a bifunctional quinoline building block with the molecular formula C₉H₇BrN₂ and a molecular weight of 223.07. It presents as a solid and carries two handles on a single heteroaromatic core: a bromine atom at the 4...Read more -
The Heterocyclic Building Block Behind Targeted Protein Degradation and Next-Generation Kinase Inhibitors:Methyl 2-Aminooxazole-4-Carboxylate (CAS 1000576-38-4)
Methyl 2-aminooxazole-4-carboxylate (CAS 1000576-38-4), also named methyl 2-amino-1,3-oxazole-4-carboxylate, is a small heterocyclic building block with the molecular formula C₅H₆N₂O₃ and a molecular weight of 142.11. It presents as a crystalline solid and carries two orthogonal handles on a sing...Read more -
The Differentiated Quinoxalinone Scaffold for Kinase Inhibitors, HDAC Modulators, and ALDH-Targeted Therapeutics: Methyl 3-Oxo-3,4-dihydro-6-quinoxalinecarboxylate (CAS# 357637-38-8)
Methyl 3-oxo-3,4-dihydro-6-quinoxalinecarboxylate (CAS# 357637-38-8), also known as methyl 3-oxo-3,4-dihydroquinoxaline-6-carboxylate, 3,4-dihydro-3-oxo-6-quinoxalinecarboxylic acid methyl ester, or methyl 3-oxo-4H-quinoxaline-6-carboxylate, is a heterobicyclic quinoxalinone ester with the molecu...Read more -
The Essential Fluorinated Nitroaromatic Building Block for Enzalutamide, Apalutamide, and Advanced Pharmaceutical Intermediates: 2-Fluoro-4-nitrobenzoic Acid (CAS# 403-24-7)
2-Fluoro-4-nitrobenzoic acid (CAS# 403-24-7), also known as 4-carboxy-3-fluoronitrobenzene or 4-nitro-2-fluorobenzoic acid, is a fluorinated nitroaromatic carboxylic acid with the molecular formula C₇H₄FNO₄ and a molecular weight of 185.11 g/mol. Its molecular structure features a benzoic acid co...Read more -
The Pre-Functionalized 2-Aminothiazole Scaffold for Kinase Inhibitor Discovery, Metabolic Stability Optimization, and Late-Stage SAR Diversification: 5-Bromo-4-isopropylthiazol-2-amine (CAS# 102570...
5-Bromo-4-isopropylthiazol-2-amine (CAS# 1025700-49-5), also known as 2-amino-5-bromo-4-isopropylthiazole, 5-bromo-4-propan-2-yl-1,3-thiazol-2-amine, or 5-bromo-4-(1-methylethyl)-2-thiazolamine, is a functionalized heterocyclic building block with the molecular formula C₆H₉BrN₂S and a molecular w...Read more -
The Privileged Heterocyclic Primary Amine Building Block for GABA A Receptor Modulators, GSK3 Kinase Inhibitors, and HIV-1 Protease Inhibitors: 4-Aminoisoxazole (Isoxazol-4-amine, CAS# 108511-97-3)
4-Aminoisoxazole (CAS# 108511-97-3), also known as isoxazol-4-amine, 1,2-oxazol-4-amine, or isoxazole-4-amine, is a heterocyclic primary amine with the molecular formula C₃H₄N₂O and a molecular weight of 84.08 g/mol. Its molecular structure features a five-membered isoxazole ring bearing a primar...Read more -
The Chemoselective Bifunctional Alkylating Agent for Pentoxifylline Synthesis, Pharmaceutical Intermediates, and Specialty Agrochemicals: 6-Bromohexan-2-one (CAS# 10226-29-6)
6-Bromohexan-2-one (CAS# 10226-29-6), also known as 6-bromo-2-hexanone, 5-oxohexyl bromide, 1-bromo-5-hexanone, or 4-bromobutyl methyl ketone, is a C6 aliphatic bromoketone with the molecular formula C₆H₁₁BrO and a molecular weight of 179.05 g/mol. Its molecular structure combines a terminal prim...Read more
