2-Amino-5-thiazolemethanol (CAS 131184-73-1), also named (2-amino-1,3-thiazol-5-yl)methanol or 2-amino-5-(hydroxymethyl)thiazole, is a compact heterocyclic building block with the molecular formula C₄H₆N₂OS and a molecular weight of only 130.17 g/mol. It presents as a yellow to off-white solid with a melting point of 102–103 °C and a predicted boiling point near 340 °C. The molecule’s commercial value lies in a structural economy that larger, more elaborate building blocks cannot match. On a single five-membered thiazole ring, it carries two orthogonal reactive handles: a nucleophilic primary amine at the 2-position and a primary hydroxymethyl group at the 5-position. The amino group participates in acylation, sulfonylation, reductive amination, diazotization and Schiff-base formation; the hydroxymethyl group can be oxidised to an aldehyde or carboxylic acid, esterified, etherified or displaced in nucleophilic substitution; and the thiazole ring itself provides an electron-rich, metabolically stable heteroaromatic core that engages in hydrogen bonding and π-stacking. That dual functionality on a privileged 2-aminothiazole scaffold is why the compound appears in pharmaceutical intermediate synthesis, agrochemical discovery and specialty reagent chemistry, and why it is specifically valued as a reactant for preparing imino-quinone methide intermediates—highly reactive species used to build complex heterocyclic architectures. The market is not a tonnage market. It is a research-to-pilot specialty chemical supplied at ≥97% purity (with ≥98% grades available) in milligram-to-kilogram packages, and its commercial logic is defined by analytical confidence and supply reliability rather than by commodity scale. The qualifying question for buyers is therefore not “what does a kilogram cost” but “which supplier can deliver a reproducible lot, with lot-specific analytical data, before the discovery programme loses time.”
Core Application Fields and Demand Architecture
Demand for 2-amino-5-thiazolemethanol concentrates in four functional arenas, with pharmaceutical intermediate manufacturing and drug discovery accounting for approximately 45–50% of global consumption, agrochemical development and pesticide synthesis for 25–30%, analytical chemistry and specialty reagents for 15–20%, and specialty materials and bioactive substance synthesis for the remaining 10–15%.
In pharmaceutical intermediate manufacturing and drug discovery, the compound functions as a privileged building block for complex molecules. The 2-aminothiazole scaffold is a recurring structural motif in medicinal chemistry, forming the backbone of therapeutic agents with antimicrobial, antifungal, anti-inflammatory and anticancer activity, and the 5-hydroxymethyl group provides a site for medicinal chemistry modification that can modulate the electronic properties and biological activity of the resulting molecule. The compound has been identified as useful in the search for novel autotaxin (ATX) inhibitors, a target implicated in fibrosis and cancer, and it is catalogued as a reactant for imino-quinone methide chemistry, which is used to construct drug-like heterocyclic systems. This is the segment where the building block’s value is highest, because the cost of an off-spec lot or a failed reaction is measured in lost synthesis time rather than in the price of the gram.
In agrochemical development and pesticide synthesis, the 2-aminothiazole scaffold is a common structural motif in modern crop protection agents, and the compound’s dual reactive handles enable the construction of fungicides, herbicides and insecticides. The thiazole moiety is associated with antimicrobial and antifungal activity, making derivatives of this building block valuable for developing novel crop-protection actives. This segment is smaller in value than pharmaceutical discovery but larger in potential volume, and it connects the building block to agricultural cycles that are less dependent on pharmaceutical R&D funding.
Analytical chemistry and specialty reagent applications form the third arena. The compound’s functional groups enable derivatization of analytes for enhanced detection and quantification, and its defined structure and high purity make it suitable as a reference standard in analytical method development and validation. Specialty materials and bioactive substance synthesis—including vitamins, biologically active substances and cationic dyes—complete the demand base, with derivatives also explored in materials science and coordination chemistry.
Regulatory Profile: A GHS07 Irritant on the TSCA Inventory, Governed by Handling Discipline and Analytical Identity
2-Amino-5-thiazolemethanol is not a CMR substance and is not classified as a persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) substance. Its regulatory identity is defined by a GHS07 irritant classification, TSCA inventory listing, and the analytical specifications that determine whether the material is fit for its intended application.
The hazard profile is that of a solid irritant. Under GHS, the compound carries the signal word “Warning” with hazard statements H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation); some SDS documentation additionally reports H312 (harmful in contact with skin) and H332 (harmful if inhaled). These are handling hazards, not carcinogenicity, mutagenicity or reproductive toxicity classifications, and the required precautions are standard for a fine-chemical solid: avoid breathing dust, wear protective gloves and eye/face protection, use in a well-ventilated area, and store the container tightly closed.
Inventory status is favourable in the key market. The compound is listed on the TSCA Inventory in the United States, meaning it can be manufactured or imported for commercial purposes without a Premanufacture Notice. It is not listed in China’s Catalog of Hazardous Chemicals 2015, which simplifies domestic handling and transport within China. For Russian and EAEU buyers, the compound is imported at research and pilot scale, and the practical documentation expectations are a Certificate of Analysis reporting identity and purity by HPLC, a Russian-language SDS reflecting the GHS07 classification, and confirmation that the material is the 2-amino-5-hydroxymethyl isomer rather than a positional analogue.
The analytical specification is where the regulatory and quality dimensions converge. The compound is typically supplied at ≥97% purity by HPLC or GC, with ≥98% grades available, and it should be stored at 2–8 °C under argon, protected from light and moisture. A lot that has absorbed moisture or degraded during storage may still assay within specification but deliver poor results in a coupling or oxidation step, so the supplier’s packaging and storage discipline are part of the product’s fitness for use.
Global Supply Structure and Manufacturer Differentiation
Global supply of 2-amino-5-thiazolemethanol is moderately fragmented and structured around three tiers: multinational research-chemical distributors serving the high-purity research segment, Chinese manufacturers serving both domestic and export demand at industrial and research scale, and specialty producers offering custom synthesis and kilogram-scale supply. The suppliers visible in public listings include Sigma-Aldrich (Merck), Aladdin Scientific, TargetMol, CymitQuimica (Indagoo brand), GlpBio, Santa Cruz Biotechnology, Chemenu, AK Scientific, BLD Pharmatech, Capot Chemical, Bide Pharmatech, MolCore, Beyotime Biotechnology, Macklin, Acmec, Solarbio and a cohort of other Chinese producers. Purity specifications span 95% to 99%, with 97% as the most common commercial grade, and package sizes range from 100 mg to 5 g at catalogue scale, with kilogram and multi-kilogram quantities available on custom order.
Differentiation operates on three axes. The first is analytical depth and lot-specific data. Suppliers that provide HPLC and NMR results for the specific lot, rather than a generic specification, reduce the buyer’s need to re-characterise material before use. In imino-quinone methide chemistry and medicinal chemistry programmes, where the building block is incorporated into a complex molecule and purification is expensive, the cost of an off-spec lot is measured in lost synthesis time rather than in the price of the gram. The second axis is scale-up and custom-synthesis capability. A supplier that can follow a programme from a 100 mg catalogue purchase to kilogram-scale custom quantities, without changing the analytical method or the impurity profile, is more valuable than a catalogue vendor that cannot support the later stage. Capot Chemical, for example, is identified as offering kilogram-scale production and long-term commercial supply support, which illustrates the service dimension that process-scale buyers expect. The third axis is documentation and language support. For Russian and EAEU buyers, a Russian-language SDS and a Certificate of Analysis that reports lot-specific purity are baseline expectations, because the material is imported and the buyer’s incoming QC must be able to qualify it without re-characterising every lot.
Regional Demand Dynamics
Demand for 2-amino-5-thiazolemethanol follows the geography of pharmaceutical discovery and agrochemical development rather than the geography of chemical manufacturing.
North America and Europe are the principal demand centres for the high-purity research-grade material, reflecting the concentration of medicinal chemistry groups, contract research organisations and agrochemical discovery programmes in these regions. Demand is project-driven and small in absolute mass: a single discovery group may purchase 100 mg to a few grams at a time, and a programme that advances may require tens to hundreds of grams. Buyers in these regions place weight on lot-specific analytical data, supplier documentation and the ability to source from a supplier with a TSCA-listed position for U.S. programmes.
Asia-Pacific, and China in particular, is the manufacturing and stock-holding hub for the compound. Chinese producers offer the building block at 97–99% purity across package sizes from grams to multi-kilogram quantities, serving both domestic pharmaceutical and agrochemical R&D and export markets. The region’s demand is growing as domestic drug-discovery and agrochemical research expands, and Chinese suppliers are increasingly capable of providing lot-specific analytical data alongside the product. For Russian and EAEU buyers, China is the most accessible source of supply, and the practical qualification task centres on verifying the Certificate of Analysis and the SDS rather than on navigating a complex regulatory approval pathway.
Russia and the EAEU form a small, import-dependent contour. Demand comes from pharmaceutical R&D, agrochemical development and analytical laboratories, and supply is sourced from Chinese and international catalogue vendors. There is no meaningful domestic production of the compound, and the practical constraint is availability at the required purity and package size rather than regulatory restriction. Buyers in the region place a premium on suppliers that can provide a Russian-language SDS, a lot-specific Certificate of Analysis and reliable delivery of small packages, because a delayed gram can stall a synthesis campaign.
Future Outlook and Strategic Imperatives
The commercial trajectory of 2-amino-5-thiazolemethanol is tied less to its own market size than to the therapeutic and agrochemical programmes it enables. The 2-aminothiazole scaffold remains a privileged structure in medicinal chemistry, and the compound’s dual handles make it a versatile entry point for programmes targeting antimicrobial, antifungal, anti-inflammatory and anticancer activity, as well as for imino-quinone methide chemistry and autotaxin inhibition. Agrochemical discovery provides a second demand stream that is connected to crop-protection cycles rather than to pharmaceutical R&D spending, and custom synthesis adds a service layer that grows with every programme that chooses the aminothiazole scaffold.
Three structural forces will shape the supply landscape. First, analytical transparency will remain the primary differentiator. As programmes mature, the building block’s purity and impurity profile directly affect the purity of the final active, and buyers will increasingly require lot-specific HPLC and NMR data rather than a nominal percentage. Second, the transition from catalogue to custom scale will separate suppliers that can support a programme’s growth from those that can only fill a small-pack order. A supplier that can lock a specification at 100 mg and reproduce it at kilogram scale, with the same impurity profile, will be preferred for process development. Third, documentation and language support will matter more in import-dependent markets such as Russia and the EAEU, where the buyer’s incoming QC carries the qualification burden.
For Russian and EAEU buyers, the strategic implication is that procurement should be treated as a specification-and-documentation decision rather than a price comparison. A nominal 97% lot that fails to meet the programme’s purity requirement, or a shipment that arrives without a Russian-language SDS and lot-specific analytical data, can cost more in lost synthesis time than the price difference between two suppliers. The lowest-risk source is the one that can provide lot-specific HPLC and NMR data, confirm the 2-amino-5-hydroxymethyl substitution pattern, and support the programme as it scales.
Shanghai XinChem Co., Ltd. (XinChem)
As a world-leading supplier of organic chemicals, Shanghai XinChem Co., Ltd. (XinChem) offers 2-amino-5-thiazolemethanol (CAS 131184-73-1) in research-grade and custom-synthesis specifications, serving medicinal chemistry groups, pharmaceutical intermediate manufacturers, agrochemical discovery teams and analytical laboratories. Our material is supplied with lot-specific analytical data, controlled purity and the documentation support that aminothiazole building-block qualification requires at both catalogue and scale-up stages.
Technical and Quality Advantages
Lot-Specific HPLC and NMR Data: 2-Amino-5-thiazolemethanol is supplied with a Certificate of Analysis reporting identity and purity by HPLC and NMR for the specific lot, rather than a generic catalogue specification. For medicinal chemistry and imino-quinone methide programmes, where the building block’s impurity profile affects downstream coupling and purification, lot-level data allows the buyer to qualify the material against the programme’s actual requirements.
Dual-Handle Reactivity Confirmation: The material is controlled for the 2-amino-5-hydroxymethyl substitution pattern, with analytical data that confirms both handles are available for the intended chemistry. This specification is more informative than a headline HPLC percentage, because a positional isomer or a partially derivatised lot can behave differently in acylation, oxidation or condensation and introduce a downstream impurity.
Purity at the ≥97% Threshold with Scale-Up Continuity: Material is available at ≥97% purity (HPLC), consistent with the commercial research-grade specification, with ≥98% grades available on request, and can be supplied in custom-synthesis quantities under a locked specification. A programme that begins with a 100 mg qualification lot can later scale without changing the analytical method or the impurity profile.
Regulatory and Documentation Support: Safety data sheets are available in English and Russian, with documentation covering the GHS07 irritant classification (H302, H315, H319, H335) and the TSCA-listed inventory position. For EAEU buyers, the Russian-language SDS and Certificate of Analysis support incoming qualification, and for U.S.-linked programmes the TSCA listing simplifies commercial sourcing.
Packaging and Logistics Flexibility
2-Amino-5-thiazolemethanol is available in sealed 100 mg, 250 mg, 1 g and 5 g containers for research and medicinal chemistry use, and in larger package sizes for custom-synthesis and process-development quantities. The product should be stored at 2–8 °C under argon, protected from light and moisture, and shipped with appropriate temperature control. For Russia and EAEU destinations, XinChem arranges logistics with appropriate customs and transport documentation, including Russian-language SDS and Certificate-of-Analysis support, to reduce clearance friction for a building block that is sourced internationally at research and process scale.
Application Support and Supply Reliability
XinChem’s technical team assists with grade selection for pharmaceutical intermediate synthesis, imino-quinone methide chemistry, agrochemical active construction and analytical derivatisation, and with the analytical and documentation requirements that aminothiazole building-block qualification demands. Supply schedules accommodate both catalogue-scale qualification orders and custom-synthesis volumes, with stock held for the package sizes most commonly requested in medicinal chemistry and agrochemical programmes.
Why Choose XinChem
Expertise: Deep experience in aminothiazole and heterocyclic building blocks, with application knowledge spanning pharmaceutical discovery, agrochemical synthesis and analytical chemistry.
Consistency: Lot-specific control of identity, HPLC purity and substitution pattern—the parameters that determine whether the building block incorporates cleanly into a target molecule or introduces a purification burden.
Compliance Readiness: Documentation structured around the GHS07 irritant classification, the TSCA-listed inventory position and EAEU documentation expectations, with Russian-language SDS support.
Responsiveness: Direct technical and commercial access, with order structures from 100 mg qualification quantities to custom-synthesis volumes.
Contact us now to discuss your 2-amino-5-thiazolemethanol requirements and request a specification sheet or qualification sample.
Website: www.xinchem.com
Email: sales1@xinchem.com
WhatsApp: +86 18049800532
Post time: Nov-01-2026