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2-Fluoro-4-nitrobenzoic acid (CAS# 403-24-7), also known as 4-carboxy-3-fluoronitrobenzene or 4-nitro-2-fluorobenzoic acid, is a fluorinated nitroaromatic carboxylic acid with the molecular formula C₇H₄FNO₄ and a molecular weight of 185.11 g/mol. Its molecular structure features a benzoic acid core bearing a fluorine atom at the 2-position and a nitro group at the 4-position, creating a highly functionalized aromatic scaffold with three distinct reactive handles. This specific 2-fluoro-4-nitro substitution pattern—combining an electron-withdrawing fluorine atom, a strongly electron-withdrawing nitro group, and a carboxylic acid functionality—confers unique electronic properties that make it an indispensable building block in modern medicinal chemistry and pharmaceutical manufacturing.

As an off-white to pale yellow crystalline powder with a melting point of 169–176°C, a predicted boiling point of 352.5 ± 27.0°C at 760 mmHg, a density of 1.568 ± 0.06 g/cm³, and a predicted pKa of 2.37 ± 0.13, the compound is soluble in polar organic solvents such as DMSO and DMF but has limited aqueous solubility. It is typically supplied at ≥97% and ≥98% purity (HPLC) and should be stored in a cool, dry place (2–8°C recommended) protected from light and moisture. Under GHS, it is classified with the signal word “Warning” (H302, H315, H319, H335) and requires standard laboratory safety precautions during handling.

2-Fluoro-4-nitrobenzoic acid is a strategically important fluorinated nitroaromatic building block that serves as the key starting material for Enzalutamide (Xtandi®) —a blockbuster androgen receptor inhibitor used in the treatment of castration-resistant prostate cancer—and as a critical precursor for Apalutamide (Erleada®) , another androgen receptor inhibitor for prostate cancer. Its unique combination of a carboxylic acid handle, a fluorine atom, and a nitro group enables diverse chemical transformations, including amidation, nitro reduction, and nucleophilic aromatic substitution, positioning it as an indispensable tool in modern pharmaceutical synthesis and drug discovery. Based on its chemical characteristics and industrial significance, this article systematically analyzes the key properties, core application areas, global market structure, regulatory landscape, and future outlook of this strategically important fluorinated aromatic building block.

Core Application Fields and Demand

Market demand for 2-fluoro-4-nitrobenzoic acid (CAS# 403-24-7) is concentrated in three primary sectors: pharmaceutical synthesis and API manufacturing (approximately 60–65% of global consumption), agrochemical development (approximately 20–25%), and organic synthesis and specialty chemicals (approximately 10–15%). Its role as the essential intermediate for blockbuster prostate cancer drugs and its versatility as a fluorinated building block serve as the core drivers of sustained demand growth.

In pharmaceutical synthesis and API manufacturing, 2-fluoro-4-nitrobenzoic acid is the critical starting material for the synthesis of Enzalutamide (Xtandi®) , a potent androgen receptor (AR) inhibitor developed by Astellas and Pfizer for the treatment of castration-resistant prostate cancer. The synthesis of Enzalutamide from 2-fluoro-4-nitrobenzoic acid typically involves three key steps: chlorination and subsequent methylamination to produce 2-fluoro-N-methyl-4-nitrobenzamide in 95% yield, followed by nitro reduction and substitution with cyclobutanone and sodium cyanide to give N-methyl-2-fluoro-4-(1-cyanocyclobutylamino)benzamide—the key Enzalutamide precursor. The compound is also a key intermediate for Apalutamide (Erleada®) , another androgen receptor inhibitor approved for non-metastatic castration-resistant prostate cancer. The preparation of Apalutamide from 2-fluoro-4-nitrobenzoic acid involves amidation, nitroreduction, and substitution reactions. The compound is also a documented impurity of Apalutamide (Apalutamide Impurity 15) , making it an analytically critical reference standard for pharmaceutical quality control. Beyond prostate cancer therapeutics, 2-fluoro-4-nitrobenzoic acid serves as a key intermediate for the synthesis of antibacterial agents, anticancer drugs, and other nitroaromatic bioactive compounds. The fluorine atom enhances metabolic stability, lipophilicity, and target binding affinity of downstream drug candidates, while the nitro group provides a versatile handle for reduction to aniline intermediates or further functionalization.

In agrochemical development, 2-fluoro-4-nitrobenzoic acid is utilized as a key intermediate in the formulation of pesticides and herbicides, contributing to the design of effective agricultural products. The compound serves as a building block for herbicides, fungicides, and plant growth regulators. The fluorine atom enhances the metabolic stability and environmental persistence of agrochemical active ingredients, while the nitro group provides a site for further functionalization. The compound is also employed in the production of various agrochemical products essential for modern agricultural practices.

In organic synthesis and specialty chemicals, 2-fluoro-4-nitrobenzoic acid serves as a versatile precursor for functionalized benzoic acid derivatives via decarboxylation or coupling reactions. The compound is used as a reagent in organic synthesis for the preparation of fluorinated aromatic compounds, heterocycles, and specialty materials. It is also employed as a precursor for the synthesis of fluorine-containing compounds for material science applications.

Key Properties and Reactivity Profile

2-Fluoro-4-nitrobenzoic acid (CAS# 403-24-7) is a trifunctional fluorinated nitroaromatic whose value derives from the orthogonal reactivity of its carboxylic acid, fluorine, and nitro substituents.

Key physicochemical parameters include:

Molecular Formula: C₇H₄FNO₄
Molecular Weight: 185.11 g/mol
CAS Number: 403-24-7
EINECS Number: 609-823-5
MDL Number: MFCD00275565
Synonyms: 4-Carboxy-3-fluoronitrobenzene; 4-Nitro-2-fluorobenzoic acid; Benzoic acid, 2-fluoro-4-nitro-
IUPAC Name: 2-fluoro-4-nitrobenzoic acid
Appearance: Off-white to pale yellow crystalline powder
Purity: ≥97% (HPLC); ≥98% (HPLC) available
Melting Point: 169–176°C (literature values vary; 160–163°C and 174–177°C reported in different sources)
Boiling Point: 352.5 ± 27.0°C at 760 mmHg (predicted)
Density: 1.568 ± 0.06 g/cm³ (predicted)
pKa: 2.37 ± 0.13 (predicted)
LogP: 1.71
Topological Polar Surface Area: 83.1 Å²
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 1
SMILES: O=C(O)C1=CC=C(N+=O)C=C1F
InChIKey: MMWFMFZFCKADEL-UHFFFAOYSA-N
Solubility: Soluble in DMSO, DMF, methanol; slightly soluble in water
Storage: 2–8°C, sealed in dry, protect from light and moisture
GHS Classification: Warning; H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
Hazard Symbols: GHS07 – Harmful/Irritant
Precautionary Statement(s): P261, P305+P351+P338
Transport Classification: Non-hazardous (non-DG according to IATA/IMDG)
HS Code: 2916399090

The compound’s reactivity is defined by its three orthogonal handles: the carboxylic acid group enables amidation, esterification, and salt formation; the nitro group at the 4-position provides a site for reduction to the corresponding aniline, which can then undergo further functionalization (diazotization, acylation, cyclization); and the fluorine atom at the 2-position activates the aromatic ring toward nucleophilic aromatic substitution and modulates the electronic environment of the molecule. The 2-fluoro-4-nitro substitution pattern is critical for the biological activity of downstream drug candidates—the fluorine atom enhances metabolic stability and lipophilicity, while the nitro group provides a handle for the key reductive transformations in Enzalutamide and Apalutamide synthesis. The compound is stable under standard conditions but should be kept away from strong oxidizing agents.

Major Market Participants

The global supply system for 2-fluoro-4-nitrobenzoic acid (CAS# 403-24-7) features a pattern of “specialized pharmaceutical intermediate manufacturers, multinational research chemical distributors, and Chinese producers serving distinct market segments.” As a specialized fluorinated nitroaromatic building block rather than a bulk commodity, the market is characterized by a moderate number of suppliers catering to pharmaceutical R&D, API manufacturing, and agrochemical development.

In the global research and high-purity segment, key international suppliers include Thermo Fisher Scientific (Thermo Scientific Chemicals) , offering the compound at 98% purity under catalog number L19770.06 (5 g) and L19770.03, with assay (HPLC) ≥97.5%, melting point 169.0–176.0°C, and appearance as white to pale cream or pale yellow crystals or powder. Tokyo Chemical Industry (TCI) offers the compound under product code F0797, with the molecular formula C₇H₄FNO₄ and molecular weight 185.11. Apollo Scientific (UK) offers the compound under product code PC3912, with batch-specific Certificates of Analysis available. J&K Scientific offers the compound at 98% purity under product code 310797. CymitQuimica (Indagoo brand) offers the compound at 97% purity under product code 10-F008351, with pricing from €14.00 to €629.00. VWR International offers the compound at 97% purity from AMBEED, Inc., with appearance as crystal-powder, white to yellow color, and storage sealed in dry conditions. Biozol (Germany) offers the compound under CAS 403-24-7 at €389.00. BenchChem offers the compound with stock available for continuous flow chemistry and cGMP synthesis, with standard pack sizes of 5 g, 25 g, 100 g, 500 g, and bulk custom. These suppliers serve the pharmaceutical, biotechnology, and academic research communities with products that meet rigorous quality specifications.

In the industrial and large-scale production segment, Chinese manufacturers have emerged as significant players in the global supply chain. XinChem is a reliable manufacturer and supplier of high-purity 2-fluoro-4-nitrobenzoic acid from China, offering the compound with stringent quality standards for use in Enzalutamide synthesis, Apalutamide manufacturing, and pharmaceutical intermediate applications. XinChem provides the compound as an off-white to pale yellow crystalline powder with comprehensive quality documentation, batch-specific Certificates of Analysis (COA), customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing. The company emphasizes that 2-fluoro-4-nitrobenzoic acid is a key starting material for the synthesis of Enzalutamide and Apalutamide, and is primarily employed in laboratory-based pharmaceutical research and development, as well as in the production of antibacterial agents, anticancer drugs, and agrochemical actives. Other Chinese suppliers include Bide Pharmatech (毕得医药), offering the compound at 97% purity under catalog number BD8070 with batch quality inspection reports (NMR, HPLC, GC) and pricing from ¥17.00 for 250 mg to ¥22.00 for 1 g. Beyotime Biotechnology (碧云天) offers the compound at 98% purity under product code Y045931, with packaging sizes of 5 g (¥65.00), 20 g (¥221.00), and 100 g (¥882.00). Capot Chemical (科邦特) offers the compound at 99% minimum purity (HPLC) with moisture ≤0.5% and melting point 170°C, with kilogram-scale production and long-term commercial supply support. Macklin (麦克林) offers the compound at 99% purity under product code F810050, with 25 g pricing at ¥198.00 and 100 g at ¥769.00. Shanghai Aladdin Biochemical Technology offers the compound under CAS 403-24-7. Jinan Finer Chemical offers the compound with a production capacity of 20 metric tons per year and a minimum order quantity of 100 grams. Ningbo Inno Pharmchem offers the compound as a preferred nitroaromatic compounds supplier in China for complex synthesis workflows, with purity (HPLC) ≥99.0%, moisture content ≤0.5% (Karl Fischer), residual solvents ≤500 ppm (GC analysis), and heavy metals ≤10 ppm (ICP-MS). Chinese suppliers offer the compound at various purity grades (typically 97–99%) and packaging options—from grams to multi-kilogram quantities and 25 kg sealed polyethylene-lined fiber drums—serving both domestic and export markets.

Regional Market Dynamics

The global 2-fluoro-4-nitrobenzoic acid market exhibits distinct regional characteristics, with production concentrated in Asia-Pacific (particularly China) and consumption distributed across North America, Europe, and the Asia-Pacific region, aligned with the pharmaceutical, agrochemical, and specialty chemical industries in these regions. According to the 2-Fluoro-4-Nitrobenzoic Acid (CAS 403-24-7) Industry Research 2025, comprehensive data is available globally and regionally covering Europe, Asia, North America, and other regions, including market trends from 2019–2024 with forecasts extending to 2029.

The Asia-Pacific region has emerged as a significant production hub for 2-fluoro-4-nitrobenzoic acid, with China hosting numerous manufacturers and suppliers including XinChem. The region’s competitive advantages include lower production costs, established chemical infrastructure, and proximity to rapidly growing pharmaceutical and agrochemical industries. Chinese suppliers offer the compound at various purity grades (typically 97–99%) and packaging options, serving both domestic and export markets. The growing pharmaceutical R&D, Enzalutamide and Apalutamide generic manufacturing, and agrochemical sectors in China, India, Japan, and South Korea continue to drive regional consumption growth. The compound is classified as a pharmaceutical intermediate and organic synthesis intermediate in the Chinese market, with multiple suppliers offering the product in packaging sizes ranging from 250 mg to 25 kg.

North America remains a key market for high-purity and research-grade 2-fluoro-4-nitrobenzoic acid, driven by demand from the pharmaceutical industry, biotechnology companies, and academic research institutions. The United States hosts numerous research organizations, pharmaceutical companies, and contract research organizations that require high-quality fluorinated nitroaromatic building blocks for Enzalutamide and Apalutamide manufacturing, as well as for drug discovery programs targeting prostate cancer and other diseases. Thermo Fisher Scientific, VWR International, BenchChem, and BOC Sciences serve the North American market with extensive distribution networks. The region’s well-established regulatory framework, including FDA oversight of oncology drug manufacturing, supports demand for high-grade research chemicals and pharmaceutical intermediates.

Europe is characterized by stringent regulatory requirements, including REACH registration, and a strong focus on quality and sustainability in pharmaceutical and agrochemical applications. European pharmaceutical companies, agrochemical developers, and research institutions demand high-purity fluorinated nitroaromatic intermediates with comprehensive documentation. Apollo Scientific (UK), CymitQuimica, and Biozol (Germany) serve the European market with in-stock availability. The compound is registered under REACH with EINECS number 609-823-5. The region’s advanced pharmaceutical and biotechnology sectors support steady demand for high-quality Enzalutamide and Apalutamide intermediates.

Japan represents a specialized market where 2-fluoro-4-nitrobenzoic acid is supplied by Tokyo Chemical Industry (TCI) and other distributors for pharmaceutical research, agrochemical development, and fine chemical applications.

Regulatory and Safety Considerations

As a fluorinated nitroaromatic carboxylic acid and pharmaceutical intermediate, 2-fluoro-4-nitrobenzoic acid (CAS# 403-24-7) is subject to regulatory oversight in major global economies. Compliance with relevant regulations is essential for market access and trade.

GHS classification and handling: 2-Fluoro-4-nitrobenzoic acid is classified with the signal word “Warning”. Hazard statements include H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). The compound is classified as Acute Tox. 4 (Oral) , Skin Irrit. 2, Eye Irrit. 2, and STOT SE 3 (respiratory system). Precautionary statements include P261 (Avoid breathing dust/fume/gas/mist/vapours/spray), P264 (Wash skin thoroughly after handling), P270 (Do not eat, drink or smoke when using this product), P271 (Use only outdoors or in a well-ventilated area), P280 (Wear protective gloves/protective clothing/eye protection/face protection), P301+P317 (IF SWALLOWED: Get medical help), P302+P352 (IF ON SKIN: Wash with plenty of water), P304+P340 (IF INHALED: Remove person to fresh air and keep comfortable for breathing), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing), P312 (Call a POISON CENTER or doctor if you feel unwell), P330 (Rinse mouth), P332+P317 (If skin irritation occurs: Get medical help), P362+P364 (Take off contaminated clothing and wash it before reuse), P403+P233 (Store in a well-ventilated place; keep container tightly closed), P405 (Store locked up), and P501 (Dispose of contents/container to an approved waste disposal plant). The compound is classified as GHS07 – Harmful/Irritant. Personal protective equipment including lab gloves, safety glasses, and a lab coat should be worn during handling, and operations should be conducted in a well-ventilated environment or fume hood. The WGK Germany classification is 3 (high hazard to water).

Storage and stability: 2-Fluoro-4-nitrobenzoic acid should be stored in a cool, dry place (2–8°C recommended for long-term storage) protected from light and moisture. The compound is stable under recommended storage conditions but should be kept away from strong oxidizing agents and bases.

Regulatory compliance: In the European Union, the compound must comply with REACH registration requirements for import and use. The compound has an EINECS number of 609-823-5. Manufacturers and suppliers must provide comprehensive Safety Data Sheets (SDS) and maintain appropriate documentation. In the United States, 2-fluoro-4-nitrobenzoic acid is intended for research and development use only and is not intended for therapeutic, food, cosmetic, or consumer applications unless explicitly stated otherwise. For pharmaceutical intermediate applications, manufacturers must comply with relevant FDA regulations and quality standards. The compound is not a controlled substance.

Transport information: 2-Fluoro-4-nitrobenzoic acid is not classified as hazardous material for DOT/IATA transport purposes (non-DG according to IATA/IMDG). Proper packaging, labeling, and documentation are nevertheless required for international shipping. The compound is typically shipped at ambient temperature with appropriate protection from light and moisture. The HS code for the compound is 2916399090.

Future Outlook

The market outlook for 2-fluoro-4-nitrobenzoic acid is positive, supported by several key growth drivers across its major application segments. While the compound remains a relatively specialized fluorinated nitroaromatic building block, its essential role as the starting material for Enzalutamide and Apalutamide and its utility in pharmaceutical and agrochemical development position it for steady growth in the coming years.

Key growth drivers include:

Expansion of the Enzalutamide and Apalutamide markets: The continued global demand for Enzalutamide (Xtandi®) and Apalutamide (Erleada®)—both blockbuster androgen receptor inhibitors for prostate cancer—drives demand for the key intermediate 2-fluoro-4-nitrobenzoic acid. Rising prostate cancer incidence, expanding access to targeted therapies in developing countries, and the growth of the global oncology drug market support sustained demand. The synthesis of Enzalutamide relies on the chlorination and methylamination of 2-fluoro-4-nitrobenzoic acid, making this compound the essential starting material for the drug’s key precursor.
Growth in pharmaceutical R&D and generic drug manufacturing: The increasing emphasis on fluorine incorporation in drug design drives demand for versatile fluorinated building blocks. The compound serves as a key intermediate for the synthesis of antibacterial agents, anticancer drugs, and other nitroaromatic bioactive compounds. The growing generic drug market for Enzalutamide and Apalutamide further supports demand.
Expansion of agrochemical development: The growing global demand for novel pesticides and herbicides—driven by increasing food production needs and the development of more selective, environmentally friendly agrochemicals—supports consumption of 2-fluoro-4-nitrobenzoic acid as a key intermediate for agrochemical active ingredients.
Increasing focus on continuous flow chemistry: The development of continuous flow technology for high-risk reactions (nitration, oxidation, high-pressure processes) and the scale-up support from lab to production (100 kg to 100 MT/year) enable efficient, scalable manufacturing of 2-fluoro-4-nitrobenzoic acid for pharmaceutical and agrochemical applications.
Growth in pharmaceutical impurity standard requirements: The increasing stringency of pharmaceutical quality control requirements drives demand for well-characterized impurity reference standards. 2-Fluoro-4-nitrobenzoic acid serves as Apalutamide Impurity 15, an analytically critical impurity standard for pharmaceutical quality control.

Challenges and considerations:

Limited scale: As a specialized fluorinated nitroaromatic intermediate, the market for 2-fluoro-4-nitrobenzoic acid is smaller than that of commodity chemicals.
Competition from alternative building blocks: The market faces competition from other fluorinated nitrobenzoic acid regioisomers (e.g., 4-fluoro-2-nitrobenzoic acid, CAS 394-01-4) and alternative intermediates with similar reactivity profiles.
Handling requirements: The compound’s classification as an irritant (H302, H315, H319, H335) requires appropriate safety measures during handling and storage.
Regulatory compliance: Increasingly stringent pharmaceutical and chemical regulations may require ongoing investment in quality systems and documentation.

To succeed in this evolving market landscape, suppliers must focus on product quality (particularly purity and batch-to-batch consistency), supply chain reliability, regulatory compliance, and responsive customer service. Companies that can offer high-purity products, flexible packaging options, and technical support for pharmaceutical, agrochemical, and specialty chemical applications will be well-positioned to capture growing demand.

Shanghai XinChem Co., Ltd. (XinChem)

As a world-leading supplier of organic chemicals and pharmaceutical intermediates, Shanghai XinChem Co., Ltd. (XinChem) is dedicated to meeting the innovative needs of the pharmaceutical, agrochemical, and fine chemical industries. Leveraging extensive experience and advanced manufacturing capabilities, XinChem provides high-quality 2-Fluoro-4-nitrobenzoic Acid (CAS# 403-24-7) to customers worldwide. As a trusted manufacturer and supplier based in China, XinChem combines competitive pricing, reliable supply, and exceptional service to establish itself as a preferred partner for pharmaceutical companies, agrochemical developers, and research institutions seeking this versatile fluorinated nitroaromatic building block.

1. Technical Advantages

Advanced Synthesis and Purification Processes
XinChem utilizes state-of-the-art manufacturing facilities and rigorous quality control measures to ensure the purity, consistency, and safety of its 2-fluoro-4-nitrobenzoic acid products. The production process incorporates established synthetic routes—including the oxidation of 2-fluoro-4-nitrotoluene with potassium permanganate (KMnO₄) and other optimized oxidation methods—enabling the delivery of products with purity ≥97% (HPLC) and ≥98% (HPLC) to meet diverse application requirements. Strict process control ensures consistent product quality, minimal impurities (moisture content ≤0.5% Karl Fischer, residual solvents ≤500 ppm GC analysis, heavy metals ≤10 ppm ICP-MS), and batch-to-batch reproducibility, providing customers with reliable performance in Enzalutamide synthesis, Apalutamide manufacturing, and pharmaceutical intermediate applications.

Full-Chain Quality Control
The production process strictly adheres to international quality standards, with comprehensive quality control covering raw material sourcing, in-process monitoring, and finished product testing. Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting physical and chemical properties, purity data (HPLC), melting point (169–176°C), density (1.568 g/cm³), and impurity profiles. XinChem offers batch-specific COA, customizable packaging, and globally compliant REACH, ISO 9001, and GMP-aligned manufacturing.

2. Product Advantages

High Purity and Consistent Quality
XinChem offers 2-fluoro-4-nitrobenzoic acid with purity ≥97% (HPLC) and ≥98% (HPLC) available, ensuring optimal performance in Enzalutamide synthesis, Apalutamide manufacturing, and pharmaceutical intermediate applications. The product’s high purity minimizes the risk of unwanted side reactions and impurities, making it suitable for demanding applications in oncology drug manufacturing and drug discovery. The compound is supplied as an off-white to pale yellow crystalline powder with consistent appearance and defined melting point specifications.

Comprehensive Specifications
Key specifications include:

Molecular Formula: C₇H₄FNO₄
Molecular Weight: 185.11 g/mol
CAS Number: 403-24-7
EINECS Number: 609-823-5
Synonyms: 4-Carboxy-3-fluoronitrobenzene; 4-Nitro-2-fluorobenzoic acid; Benzoic acid, 2-fluoro-4-nitro-
MDL Number: MFCD00275565
Appearance: Off-white to pale yellow crystalline powder
Purity: ≥97% (HPLC) / ≥98% (HPLC) available
Melting Point: 169–176°C
Boiling Point: 352.5 ± 27.0°C at 760 mmHg
Density: 1.568 ± 0.06 g/cm³
pKa: 2.37 ± 0.13
LogP: 1.71
Solubility: Soluble in DMSO, DMF, methanol; slightly soluble in water
Storage: 2–8°C, sealed in dry, protect from light and moisture
GHS Classification: Warning; H302, H315, H319, H335
Transport Classification: Non-hazardous (non-DG according to IATA/IMDG)
HS Code: 2916399090

Flexible Packaging Solutions
XinChem provides a range of packaging options to accommodate diverse customer needs, from laboratory-scale quantities (1 g, 5 g, 25 g) to industrial-scale packaging (100 g, 500 g, 1 kg, 25 kg sealed polyethylene-lined fiber drums) and bulk shipments. Customized packaging solutions are available upon request, ensuring safe handling, storage, and transportation with appropriate protection from light and moisture.

3. Application Fields

As a versatile trifunctional fluorinated nitroaromatic building block, 2-Fluoro-4-nitrobenzoic Acid (CAS# 403-24-7) exhibits wide application value across multiple industries:

Pharmaceutical Synthesis and API Manufacturing:

Key starting material for Enzalutamide (Xtandi®), an androgen receptor inhibitor for castration-resistant prostate cancer
Critical precursor for Apalutamide (Erleada®), an androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer
Building block for antibacterial agents, anticancer drugs, and other nitroaromatic bioactive compounds
Intermediate for 2-fluoro-N-methyl-4-nitrobenzamide and N-methyl-2-fluoro-4-(1-cyanocyclobutylamino)benzamide synthesis
Impurity reference standard for Apalutamide (Apalutamide Impurity 15)

Agrochemical Development:

Key intermediate for pesticides and herbicides
Building block for fungicides and plant growth regulators
Precursor for agrochemical active ingredients with improved efficacy and environmental profiles

Organic Synthesis and Specialty Chemicals:

Precursor for functionalized benzoic acid derivatives via decarboxylation or coupling reactions
Reagent for the preparation of fluorinated aromatic compounds and heterocycles
Building block for fluorine-containing compounds for material science applications

4. Service Support

Technical Expertise and Customized Solutions
XinChem’s team of experienced chemists and application engineers provides full technical support throughout the customer journey—from product selection and specification development to application guidance and troubleshooting. Whether customers require optimization of synthetic routes, guidance on nitro reduction and amidation conditions for Enzalutamide synthesis, or assistance with regulatory documentation, XinChem’s technical experts are ready to help. Custom synthesis and contract manufacturing with flexible scaling from R&D to commercial quantities are available upon request.

Global Logistics and Reliable Supply
With established supply chains serving markets across Europe, North America, Asia-Pacific, and beyond, XinChem ensures timely delivery and consistent product availability. The company’s logistics team manages all aspects of international shipping, including customs clearance and documentation, with appropriate temperature control (2–8°C) and moisture protection for product stability.

Regulatory Support
XinChem provides comprehensive documentation to support regulatory compliance, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and other required certificates. The company stays current with evolving regulatory requirements in major markets, including REACH, TSCA, and other regional regulations, helping customers navigate the complexities of global trade.

5. Reasons to Choose XinChem

Professionalism: Extensive experience and deep expertise in fluorinated nitroaromatic intermediate synthesis and supply.
Quality: Rigorous quality control, high purity (≥97% to ≥98%), and adherence to international standards.
Reliability: Stable supply, competitive pricing, and timely delivery.
Flexibility: Customized solutions to meet diverse customer needs, including custom synthesis and packaging.
Service: Responsive technical support and comprehensive documentation including batch-specific COA.

Website: www.xinchem.com

Email: sales1@xinchem.com

WhatsApp: +86 18049800532

Post time: Oct-07-2026

The Essential Fluorinated Nitroaromatic Building Block for Enzalutamide, Apalutamide, and Advanced Pharmaceutical Intermediates: 2-Fluoro-4-nitrobenzoic Acid (CAS# 403-24-7)