6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS#164148-92-9)

Introduction

6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is also known as ABTI, and the following is an introduction to its properties, uses, preparation methods and safety information:Quality:6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is a white or off-white crystalline solid. It is stable at room temperature and relatively insoluble in water, but soluble in organic solvents such as carbamate and methylene chloride. The compound has low toxicity and ignition point.Use:6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is an important intermediate widely used in organic synthesis. The compound also has applications in the pharmaceutical and pesticide industries.Method:The preparation method of 6-amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is relatively simple. A commonly used synthesis method is to react 4-oxo-1,2,3,4-tetrahydroisoquinoline with carbamate, followed by N-Boc protection reaction to obtain the target product.Safety Information:6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline has low toxicity and weak skin and eye irritation. It is still a chemical and should be handled with personal protective equipment such as gloves and goggles. Care should be taken to avoid inhaling its dust or coming into contact with the skin during the operation. It should be operated in a well-ventilated area and the compound should be stored properly for safety.

Application
6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline (CAS 164148-92-9) is a Boc-protected tetrahydroisoquinoline derivative with a free primary amine at the 6-position. This high-purity building block is widely used in medicinal chemistry and pharmaceutical R&D for the synthesis of central nervous system (CNS) agents, including potential treatments for Parkinson’s, Alzheimer’s, depression, and anxiety disorders. The Boc group enables selective deprotection under mild acidic conditions, while the 6-amino group allows versatile derivatization via amide, urea, or sulfonamide formation, facilitating rapid structure-activity relationship (SAR) studies. This scaffold also serves as a key intermediate for developing kinase inhibitors, PARP inhibitors, and GPCR modulators targeting cancer, inflammation, and neurological diseases. Its rigid, saturated THIQ core enhances metabolic stability and blood-brain barrier penetration. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.