2-Amino-4,6-Difluorobenzothiazole(CAS#119256-40-5)
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29342000 |
Introduction
4,6-Difluoro-1,3-benzothiazole-2-amine, also known as 2-amino-4,6-difluorobenzothiazole, is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:- Appearance: 4,6-Difluoro-1,3-benzothiazole-2-amine is a white or yellowish crystalline solid.- Solubility: It is soluble in common organic solvents such as ethanol and dimethyl sulfoxide.Use:- Pesticides: It can also be used as a raw material for pesticides in the synthesis of compounds with insecticidal or herbicidal properties.Method:Safety Information:- 4,6-Difluoro-1,3-benzothiazole-2-amine is less toxic, but it is still a chemical that needs to be handled and stored properly.- It is an intermediate in chemical synthesis and appropriate safety measures such as wearing appropriate personal protective equipment (e.g. gloves, goggles, etc.) should be taken when performing chemical synthesis or processing.- Please refer to the relevant Safety Data Sheet for detailed safety information when using or handling.
Application
2-Amino-4,6-difluorobenzothiazole (CAS 119256-40-5) is a highly functionalized benzothiazole derivative used as a key pharmaceutical intermediate in drug discovery. The two fluorine atoms at the 4- and 6-positions enhance metabolic stability, lipophilicity, and target binding affinity. This scaffold is widely employed in medicinal chemistry for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and infectious diseases, including PI3K, CDK, and EGFR inhibitors. The amino group at the 2-position enables facile acylation, alkylation, and heterocycle formation, while the electron-deficient benzothiazole core improves pharmacokinetic properties. This intermediate is also utilized in the development of antibacterial, antiviral, and antifungal agents, as well as in agrochemical research for herbicides and fungicides. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
