5-Aminobenzothiazole(CAS#1123-93-9)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2811 |
| TSCA | Yes |
| Hazard Note | Harmful |
| Hazard Class | IRRITANT |
Introduction
5-Aminobenzothiazole is an organic compound.Quality:- 5-Aminobenzothiazole is a white to yellowish solid.- It is soluble in alcohols and acid solvents at room temperature and almost insoluble in water.- The compound has a slight aroma.Use:- It can also be used in the synthesis of antimicrobials, photosensitizers, fungicides, and some biologically active compounds.Method:There are many ways to prepare 5-aminobenzothiazole, and the following is one of the commonly used methods:- Benzothiazole is reacted in concentrated sulfuric acid to generate oxidized benzothiazole, which is then reduced to obtain 5-aminobenzothiazole.Safety Information:- 5-Aminobenzothiazole is generally considered to be of low toxicity.- During use, care should be taken to take protective measures, such as wearing gloves and glasses, and avoiding contact with skin and eyes.- Keep away from ignition and oxidants during storage and handling.- Maintain adequate ventilation during operation. In case of discomfort or accidental contact, seek medical attention promptly.
5-Aminobenzothiazole (CAS 1123-93-9) is a privileged heterocyclic scaffold widely used in medicinal chemistry and drug discovery. Its benzothiazole core with a free amino group enables facile derivatization via amidation, sulfonylation, and reductive amination, allowing rapid construction of diverse bioactive libraries. This intermediate is a key precursor for the synthesis of potent kinase inhibitors targeting PI3K, CDK, and EGFR for cancer therapy, as well as anti-inflammatory, antiviral, and antimicrobial agents. Its rigid, electron-rich structure enhances target binding affinity and metabolic stability. 5-Aminobenzothiazole also serves as a building block for fluorescent probes, agrochemicals (herbicides, fungicides), and functional materials. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-aminobenzothiazole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
