2-Amino-4-methylpyrimidine(CAS#108-52-1)

Introduction

2-Amino-4-methylpyrimidine is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:- Appearance: 2-Amino-4-methylpyrimidine is a colorless crystalline solid.- Solubility: It can be dissolved in water, alcohols and ketone solvents, and is insoluble in non-polar solvents such as hydrocarbons.- Stability: It has relatively high thermal stability and is not easy to decompose under normal conditions.Use:- Pesticide: 2-amino-4-methylpyrimidine is an important pesticide intermediate that can be used to synthesize a variety of insecticides.- Biochemical research: 2-amino-4-methylpyrimidine is also commonly used in biochemical research.Method:There are many ways to prepare 2-amino-4-methylpyrimidine, and common methods include:Amination reaction: The amino group is introduced by reacting 4-methylpyrimidine with an amination reagent such as ammonia bromide, isocyanate, etc.Methylation reaction: Methyl groups are introduced by reacting 2-aminopyrimidine with methylation reagents such as methyl bromide, methyl carbonate, etc.Safety Information:- 2-Amino-4-methylpyrimidine is considered a relatively safe compound under general conditions, but requires proper handling and storage measures.- Follow safe operating procedures during use, such as wearing personal protective equipment (e.g. gloves, glasses, etc.) and avoid direct contact with skin and eyes.- When using the compound, ensure that it is done in a well-ventilated environment, avoid inhaling its gases or dust, and avoid contact with other harmful chemicals.- When storing, 2-amino-4-methylpyrimidine should be kept in an airtight container, away from ignition and oxidants.

Application
2-Amino-4-methylpyrimidine (CAS 108-52-1) is a high-purity heterocyclic building block widely utilized in pharmaceutical and agrochemical R&D. As a key pharmaceutical intermediate, it serves as a versatile scaffold for the synthesis of APIs including FGFR4 inhibitors for targeted cancer therapy, histamine H4 receptor modulators for anti-inflammatory applications, and antiviral, antifungal, and antitumor agents. In agrochemicals, this intermediate is essential for producing systemic fungicides and insecticides, enabling effective crop protection. Beyond its core uses, this chemical building block facilitates carbonylation research in biochemistry, nucleic acid metabolism studies, and diagnostic reagent development. Its functionalized pyrimidine core allows for various derivatizations including amidation and cross-coupling, supporting rapid SAR studies in drug discovery. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 2-Amino-4-methylpyrimidine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.