4-Bromo-6-hydroxypyrimidine(CAS#1086382-38-8)

Introduction

6-Bromo-4(1H)-pyrimidinone is an organic compound. It is white crystal, has a bitter taste, is soluble in alcohol and chloroform, and is insoluble in water.6-Bromo-4(1H)-pyrimidinone has a wide range of applications in organic synthesis.There are several methods for the preparation of 6-bromo-4(1H)-pyrimidinone, and the common method is obtained by the reaction of bromohydrogen acid and 4-amino-6-hydroxypyrimidine. 4-amino-6-hydroxypyrimidine and an appropriate amount of bromohydrohydric acid are reacted under appropriate conditions to produce 6-bromo-4(1H)-pyrimidinone. The reaction conditions can be adjusted on a case-by-case basis.Safety information: 6-Bromo-4(1H)-pyrimidinone should follow general chemical safety operating procedures. It can be irritating to the skin, eyes, and respiratory system, and care should be taken to avoid contact when using it. It is very important to properly store and dispose of the waste of chemical compounds. If there are any accidents or discomforts, you should seek medical attention immediately and bring information about the compound.

Application
4-Bromo-6-hydroxypyrimidine (6-Bromo-4(1H)-pyrimidinone, CAS 1086382-38-8) is a high-purity heterocyclic building block featuring a reactive bromine at the 4-position and a hydroxyl group at the 6-position. Its pyrimidine core exhibits unique chemical properties, with the bromine enhancing reactivity for nucleophilic substitution and cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig), while the hydroxyl/enol group provides hydrogen bonding for target engagement. This versatile intermediate is used to prepare (cyclopropylmethoxy)methylpyrimidines as potent PDE10 inhibitors for CNS disorders, and serves as a key scaffold for constructing kinase inhibitors (tyrosine, JAK, CDK families) in targeted cancer therapy. Its derivatives also demonstrate promising antitubercular activity against multidrug-resistant TB (MDR-TB) and potential against KRAS-G12D mutated cancers, as well as antibacterial and antimicrobial properties. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-value API precursor with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.