5-Amino-2 3-dichloropyridine（CAS# 98121-41-6)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29333999 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
Introduction
5-Amino-2,3-dichloropyridine(5-Amino-2,3-dichloropyridine) is an organic compound with the chemical formula C5H3Cl2N. It is a white solid with a special smell.
5-Amino-2,3-dichloropyridine has many important applications. One of these is its use as an intermediate in the pharmaceutical and agricultural fields. It can be used in the synthesis of various pharmaceutical compounds and pesticides. In addition, it can also be used as a synthetic intermediate for dyes and pigments.
There are many methods for preparing 5-Amino-2,3-dichloropyridine. The common method is to react 2,3-dichloro-5-nitropyridine with ammonia. The specific reaction conditions can be optimized according to actual needs.
Regarding safety information, 5-Amino-2,3-dichloropyridine is a hazardous substance. Wear appropriate personal protective equipment such as chemical goggles, gloves and protective clothing when handling. Avoid inhaling its gas or dust, and ensure that the work area has good ventilation. In case of accidental contact, rinse skin or eyes immediately with plenty of water and seek medical help. Correct chemical safety procedures should be followed during storage and handling.
Application
5-Amino-2,3-dichloropyridine (CAS 98121-41-6) is a high-purity halogenated aminopyridine that serves as a crucial building block and versatile intermediate in pharmaceutical, agrochemical, and material science R&D. In pharmaceutical development, it is a key intermediate for synthesizing S1P1 receptor agonists, a class of immunomodulatory agents pursued for autoimmune and inflammatory disorders. It also serves as a precursor for various heterocyclic scaffolds, including pyrazoles (with antitumor, antiviral, and anti-inflammatory activities), pyrimidines, and triazoles (used as herbicides and fungicides). In agrochemical research, this compound is employed in the synthesis of herbicides and fungicides for effective pest management. Its two reactive functional groups—the amino and chloro substituents on the pyridine ring—enable nucleophilic substitution, electrophilic aromatic substitution, and palladium-catalyzed cross-coupling reactions, allowing for the efficient construction of complex molecules. Furthermore, it finds applications in material science for developing functional materials such as dyes, polymers, and liquid crystals. High purity (≥98%) ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 5-Amino-2,3-dichloropyridine with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
