2-Aminopyrimidine(CAS#109-12-6)

Introduction

2-Aminopyrimidine is an organic compound. It is a white crystal, weakly alkaline, soluble in water, alcohols and some organic solvents.It can also be used to make dyes, rubber flame retardants, pesticides, etc.There are several methods for the preparation of 2-aminopyrimidine, and the most common method is to prepare it by ammoniating 4-cyanopyrrole. The specific step is to react 4-cyanopyrrole with ammonia gas to generate 2-aminopyrimidine.Safety Information: 2-Aminopyrimidine is stable at room temperature, but may decompose at high temperatures. It is a flammable compound and should be avoided in contact with strong oxidizing agents. Personal protective equipment such as gloves, goggles, and a lab coat should be worn during handling. Care should be taken to avoid inhalation, skin contact, and swallowing. When storing, it should be kept in a cool, dry place, away from fire and combustibles. In case of inhalation or exposure, medical attention should be sought immediately.

Application
2-Aminopyrimidine is an essential heterocyclic intermediate in the synthesis of life-sustaining pharmaceuticals such as the anticancer drug Imatinib (Gleevec), the antiviral agent Rosuvastatin, and the antibacterial Sulfadiazine. In drug discovery, it is a critical scaffold for developing potent and selective kinase inhibitors, including promising candidates targeting IKKβ for colorectal cancer therapy and next-generation EGFR inhibitors to overcome drug resistance. It is also utilized to produce the highly effective systemic fungicides ethirimol and bupirimate, which are vital for controlling powdery mildew in a wide range of crops. Furthermore, 2-aminopyrimidine serves as a versatile building block for creating functional materials, nucleoside analogs for studying biological processes, and numerous agrochemicals including herbicides and plant growth regulators. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.