3-Chloropheno!(CAS#108-43-0)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 2020 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SK2450000 |
| FLUKA BRAND F CODES | 9 |
| TSCA | Yes |
| HS Code | 29081000 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 0.57 g/kg (Deichmann) |
Introduction
M-chlorophenol is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of m-chlorophenol:Properties:- Appearance: colorless or yellowish crystal- Solubility: soluble in alcohol, ether solvents, slightly soluble in water Uses:- Preservatives: M-chlorophenol has bactericidal and antiseptic effects, and is often used in the preparation of preservatives in medical, agricultural and industrial fields. Preparation method:- M-chlorophenol can be obtained by chlorination of p-nitrobenzene. First, nitrobenzene is reacted with hydrochloric acid to produce 4-chloronitrobenzene, and then it is reduced to obtain m-chlorophenol. - Examples of preparation methods:1. Nitrobenzene is dissolved in concentrated hydrochloric acid, sodium sulfite is added under cooling conditions, and 4-chloronitrobenzene is formed by reaction. 2. Reduction of 4-chloronitrobenzene to m-chlorophenol using a reducing agent such as sodium sulfite or ammonium sulfite. Safety Information:- M-chlorophenol is irritating and corrosive. Avoid contact with skin, eyes, and respiratory tract. - Protective gloves, safety glasses, and a protective face shield are required when using m-chlorophenol. - It should be used in a well-ventilated area and away from fire and sparks. - In case of accidental ingestion or inhalation, seek medical attention immediately. - When storing m-chlorophenol, it should be stored in an airtight container, away from high temperatures and fire sources.
Application
3-Chlorophenol (m-Chlorophenol, CAS 108-43-0) is a versatile halogenated phenol widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, dyes, and specialty chemicals. In medicinal chemistry, it serves as a building block for the preparation of antimicrobial, antiviral, and anti-inflammatory drug candidates. As a critical agrochemical intermediate, 3-chlorophenol is utilized to produce selective herbicides (e.g., chlorotoluron, chloroxuron), fungicides, and insecticides, where the chlorine substituent enhances biological activity and environmental stability. Its chlorinated aromatic structure is also employed in the manufacture of polymer stabilizers, plasticizers, preservatives, and as a precursor for high-performance epoxy resins. In antiseptic and disinfectant formulations, 3-chlorophenol contributes to broad-spectrum biocidal activity against bacteria and fungi. Additionally, it functions as a pH indicator and as a reference standard for analytical method development. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3-chlorophenol with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
