3,4,5-trichloropyridazine(CAS#14161-11-6)
| Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R43 - May cause sensitization by skin contact |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1759 |
| Hazard Class | 8 |
| Packing Group | III |
Introduction
3,4,5-Trichloropyridazine is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:3,4,5-Trichloropyridazine is a colorless crystalline solid with high stability. It is soluble in water and many organic solvents at room temperature.Use:3,4,5-Trichloropyridazine has important applications in organic synthesis and pesticide manufacturing. It can be used as a raw material for insect repellents, fungicides, and herbicides.Method:There are many ways to prepare 3,4,5-trichloropyridazine, the most commonly used of which is obtained by the reaction of 1,3-dibromopropane with 2,4,5-trichlorofurane. For the specific preparation method, please refer to the relevant materials of organic synthesis.Safety Information:The following safety precautions should be paid to 3,4,5-trichloropyridazine during use and storage: avoid contact with strong oxidants, strong acids, and strong alkalis to prevent dangerous reactions. Wear appropriate protective gloves, masks, and goggles when using to ensure proper ventilation. Comply with relevant laws and regulations when disposing of waste.
Application
3,4,5-Trichloropyridazine (CAS 14161-11-6) is a highly functionalized heterocyclic building block featuring three reactive chlorine atoms on the pyridazine ring. This scaffold enables sequential regioselective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing controlled introduction of diverse substituents. It is widely used in medicinal chemistry for the synthesis of potent kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and anti-inflammatory compounds. In agrochemical research, it serves as a key intermediate for developing herbicides, fungicides, and insecticides with enhanced bioavailability and environmental safety. The rigid pyridazine core provides excellent metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 3,4,5-trichloropyridazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
