2,3-Difluoro-5-chloropyridine(CAS#89402-43-7)
| Risk Codes | R22 - Harmful if swallowed R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| Hazard Note | Harmful |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2,3-Difluoro-5-chloropyridine is an organic compound. It is a colorless to pale yellow liquid with a peculiar odor. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- It is soluble in many organic solvents such as ethanol, dimethylformamide, and chloroform.- The compound is relatively stable in air and does not decompose easily under strong acid and alkali conditions.Use:- 2,3-Difluoro-5-chloropyridine is often used as an important intermediate in organic synthesis.- It can be used in the preparation of antimicrobials, insecticides, glyphosate (a herbicide), pyridine compounds, etc.- The compound can also be used in the synthesis of aromatic compounds, such as pyridones, pyrroles, and pyrazoles.Method:- 2,3-difluoro-5-chloropyridine is prepared in a variety of ways, and the common method is obtained by the reaction of 2,5-difluoropyridine and chloroyl fluoride.- In addition, it can also be prepared by other organic synthesis methods.Safety Information:- 2,3-difluoro-5-chloropyridine is a toxic compound and should be avoided from direct contact with the skin or inhalation of its vapors.- Care should be taken to prevent ignition and avoid contact with oxidants during use or storage.- Use in laboratories or industrial production should follow relevant safety operating procedures and wear appropriate personal protective equipment such as gloves, goggles, and protective clothing.
Application
2,3-Difluoro-5-chloropyridine (5-Chloro-2,3-difluoropyridine, CAS 89402-43-7) is a key fluorinated pyridine building block. It is extensively utilized as a pharmaceutical intermediate to construct APIs with enhanced metabolic stability and bioavailability and as an agrochemical intermediate for the preparation of highly effective herbicides, insecticides, and fungicides, including the synthesis of clodinafop-propargyl. Its unique fluorine substitution pattern provides high regioselectivity in substitution reactions and excellent stability under acidic conditions. The compound also serves as a versatile scaffold for fine chemical manufacturing and as a ligand in the synthesis of metal-organic frameworks (MOFs). Xinchem offers flexible custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2,3-Difluoro-5-chloropyridine with reliable global supply from R&D to commercial tons. Contact us for a competitive quote.
