4,5-dimethylisoxazol-3-amine(CAS#13999-39-8)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
Introduction
3-Amino-4,5-dimethylisoxazole is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:Appearance: 3-amino-4,5-dimethylisoxazole is white crystalline or crystalline powder.Solubility: Insoluble in water, but soluble in organic solvents such as ethanol and ether.Molecular structure: It is an isoxazole compound that contains one amino group and two methyl groups.Use:Agriculture: In agriculture, it can be used as an insecticide to control agricultural pests such as cotton aphid, tomato spotted loon, and pear small green inchworm.Method:There are two main methods for the preparation of 3-amino-4,5-dimethylisoxazole:Isoxazole method: the reaction of 2-methylpyridine and ammonia to generate 3-amino-2-methylpyridine, and then condensation reaction with formaldehyde to prepare 3-amino-4,5-dimethylisoxazole.Isoazole compound method: N,N-dimethylformamide is used as the starting material and synthesized through a series of reaction steps.Safety Information:The safety of 3-amino-4,5-dimethylisoxazole requires further detailed laboratory and toxicological studies. In general, the following safety precautions should be taken when using this compound:Avoid inhalation, ingestion, or contact with skin and eyes.Wear appropriate protective equipment, such as lab gloves, glasses, or face shields.Maintain good ventilation conditions during operation.Do not discharge the compound directly into the water body, and appropriate treatment measures should be taken.Strictly abide by relevant laws and regulations and laboratory safety operation procedures.Before using 3-amino-4,5-dimethylisoxazole, the safety information of the compound should be detailed: follow proper handling methods to ensure personal safety and the safety of the laboratory environment.
Application
4,5-Dimethylisoxazol-3-amine is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. The isoxazole core is a privileged scaffold present in many bioactive molecules, and the free primary amine enables facile derivatization via amide coupling, urea formation, or reductive amination. This intermediate serves as a key precursor for the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including p38 MAPK, PI3K, and CDK inhibitors. It is also utilized in the development of antiviral, antibacterial, and antifungal agents. Its rigid, electron-rich isoxazole ring enhances metabolic stability and target binding affinity. Additionally, this compound supports agrochemical research for herbicides and fungicides, as well as the preparation of functional materials. High purity ensures reproducible results in high-throughput screening, structure-activity relationship studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.







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