3-(Bromomethyl)-5-methylisoxazole(CAS#130628-75-0)

Application
3-(Bromomethyl)-5-methylisoxazole (CAS 130628-75-0) is a reactive alkylating heterocyclic building block widely used in medicinal chemistry and drug discovery. The bromomethyl group enables efficient nucleophilic substitution with amines, thiols, and alcohols, allowing rapid introduction of the 5-methylisoxazole moiety into drug-like scaffolds. The isoxazole core is a privileged structure in kinase inhibitor design, particularly for p38 MAPK, PI3K, and CDK inhibitors targeting cancer, inflammation, and autoimmune diseases. This intermediate also facilitates palladium-catalyzed cross-coupling reactions after conversion to boronic esters or stannanes. Its derivatives show promising antibacterial, antifungal, and antiviral activities. In agrochemical research, it serves as a precursor for herbicides and fungicides. High purity ensures reproducible results in SAR studies and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.