3-chloro-1,2-benzisoxazole(CAS#16263-52-8)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| Hazard Note | Irritant |
Introduction
3-choro-1, 2-benzisoxazole is a chemical substance with the structural formula ClC1 = C(Cl)C2 = CC = CON2C1. The following is an introduction to some of its properties, uses, formulation and safety information:
Nature:
-Appearance: 3-chloro-1,2-benzisoxazole is a colorless crystalline or white crystalline powder.
-Melting point: Its melting point range is 133-134 degrees Celsius.
-Solubility: 3-chloro-1,2-benzisoxazole can be dissolved in organic solvents, such as alcohols and ketones, but it is difficult to dissolve in water.
Use:
-Pesticide: 3-choro-1, 2-benzisoxazole is widely used in agricultural fields as an insecticide and fungicide. It can inhibit and kill some herbs and fungi.
Method:
-3-choro-1, 2-benzisoxazole is usually prepared by chemical synthesis methods. A common preparation method is to react benzisoxazole with thionyl chloride, followed by further processing and purification to obtain the desired product.
Safety Information:
- 3-chloro-1,2-benzisoxazole is a toxic chemical and should be used in accordance with strict safety procedures. When in use, wear appropriate protective gloves, glasses and clothing to avoid skin contact and inhalation.
-Avoid contact with strong oxidants and strong acids to prevent dangerous reactions.
-During storage, it should be stored in a sealed container, away from combustibles and fire sources.
-If you come into contact with this substance or ingest it by mistake, seek medical help immediately and provide information about the substance to your doctor.
Application
3-Chloro-1,2-benzisoxazole (CAS 16263-52-8) is a privileged heterocyclic building block for pharmaceutical R&D, primarily used in synthesizing bioactive CNS drugs. It is a key precursor for the antiepileptic agent Zonisamide and for developing new antipsychotic and antiseizure compounds via reactions with piperazine/piperidine derivatives. As a reactive intermediate, this chlorinated benzisoxazole scaffold can be functionalized through palladium-catalyzed cross-coupling (Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution (SNAr) to rapidly create diverse drug-like libraries. Beyond neuroscience, its derivatives demonstrate antimicrobial (including activity against resistant A. baumannii, MIC 6.25 µg/mL), anticancer, and anti-inflammatory potential, with applications in agrochemistry and materials science. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3-Chloro-1,2-benzisoxazole with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
