3-Methylisoxazole-4-carboxylic acid(CAS#17153-20-7)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| Hazard Note | Irritant |
Introduction
acid (acid) is an organic compound. The following is its nature, use, preparation and safety information:
Nature:
-Appearance: acid is a colorless crystalline solid;
-Solubility: Soluble in organic solvents, such as methanol, ethanol and chloroform;
-Melting Point: 140-142 ℃.
Use:
-Chemical intermediate: acid can be used as an intermediate for the synthesis of drugs and other organic compounds in the pharmaceutical field, and is used to synthesize various biologically active compounds;
-Anti-tumor drug research: The compound can be used to research and develop new anti-tumor drugs.
Method:
The preparation method of acid usually includes the following steps:
1. Take 3-methyliso-oxazole as the starting material;
2. React in an appropriate solvent, such as acetic acid or acetone, the reaction time and temperature depend on the specific reaction conditions;
3. The target product is obtained by crystallization or other separation techniques.
Safety Information:
The safety information of acid is currently insufficient. Therefore, appropriate safety measures need to be taken during handling and use, such as wearing protective gloves, goggles and suitable work clothes. In the laboratory, it is necessary to follow the corresponding operating procedures to ensure the safety of personnel. In addition, the compound may be harmful to the environment, so take appropriate measures to comply with relevant laws and regulations when handling and disposing of waste.
Application
3-Methylisoxazole-4-carboxylic acid (CAS 17153-20-7) is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. Its isoxazole core serves as a privileged scaffold in the synthesis of bioactive molecules, particularly kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., p38 MAPK, PI3K, and CDK inhibitors). The carboxylic acid group enables facile amide and ester formation, allowing rapid derivatization for structure-activity relationship (SAR) studies. This intermediate is also employed in the development of antiviral, antibacterial, and antifungal agents, as well as anti-inflammatory drugs. Its rigid, electron-rich isoxazole ring enhances metabolic stability and target binding affinity. Additionally, it supports agrochemical research (herbicides, fungicides) and the preparation of functional materials. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
