Methyl 2-Aminooxazole-4-Carboxylate(CAS#1000576-38-4)

Introduction

Methyl 2-amino-4-oxazolecarboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:Methyl 2-amino-4-oxazolecarboxylic acid is a white solid that is stable at room temperature. It has medium solubility and is soluble in common organic solvents such as dimethyl sulfoxide and methanol. It decomposes under oxidizing conditions.Uses: It is an important intermediate that is used in the synthesis of other compounds.Method:There are many ways to prepare methyl 2-amino-4-oxazolecarboxylate. A common method is obtained by the reaction of methyl 4-aminoacetate and an oxidizing agent (such as hydrogen peroxide or persulfuric acid) in the presence of a catalyst.Safety Information:Specific safety information for methyl 2-amino-4-oxazolecarboxylate: Refer to the relevant Safety Data Sheet (SDS) or consult a professional to ensure proper use and handling. When handling this compound, take care to follow relevant laboratory safety guidelines and precautions, including wearing personal protective equipment such as protective eyewear and gloves, and ensuring that it is operated in a well-ventilated area.

Application
Methyl 2-Aminooxazole-4-Carboxylate (CAS 1000576-38-4) is a versatile heterocyclic building block featuring an electron-rich oxazole core with a free primary amine at the 2-position and a methyl ester at the 4-position. This privileged scaffold is widely used in medicinal chemistry and drug discovery for the synthesis of bioactive molecules, particularly kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, and EGFR inhibitors). The amino group enables amide coupling, urea formation, and heterocycle annulation, while the methyl ester allows hydrolysis to the carboxylic acid or reduction to the alcohol, facilitating rapid structure-activity relationship (SAR) studies. This intermediate also serves as a key precursor for antiviral, antibacterial, and antifungal agents. Its rigid oxazole core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.