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5-Bromo-1H-pyrazolo[3,4-b]pyridine(CAS#875781-17-2)

Chemical Property:

Molecular Formula C6H4BrN3
Molar Mass 198.02
Density 1.894±0.06 g/cm3(Predicted)
Melting Point 198.0 to 202.0 °C
Boling Point 329.0±22.0 °C(Predicted)
Flash Point 147.6°C
Vapor Presure 0.00148mmHg at 25°C
Appearance Yellow crystal
pKa 8.66±0.40(Predicted)
Storage Condition Inert atmosphere,Room Temperature
Refractive Index 1.68
MDL MFCD05663982

Product Detail

Product Tags

Hazard Symbols Xn - Harmful
Risk Codes 22 - Harmful if swallowed
Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 3
HS Code 29333990
Hazard Class IRRITANT

 

Introduction

5-Bromo-1H-pyrazolo[3,4-b]pyridine is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:Appearance: 5-Bromo-1H-pyrazolo[3,4-b]pyridine is a colorless to pale yellow crystalline powder.Solubility: The compound is soluble in organic solvents such as chloroform, methylene chloride, and ethanol, but almost insoluble in water.Structure: It contains a pyrazole ring and a pyridine ring in its molecule, where there is a bromine atom connection between the pyrazole ring and the pyridine ring.Use:5-Bromo-1H-pyrazolo[3,4-b]pyridine can be used as an important intermediate in organic synthesis.It can also be used as a photosensitive dye and is widely used in the photosensitive layer of laser printers and copiers.Method:There are many ways to prepare 5-bromo-1H-pyrazolo[3,4-b]pyridine, and a common method is to start from pyrazolo[3,4-b]pyridine and obtain 5-bromo-1H-pyrazolo[3,4-b]pyridine by bromination.Safety Information:5-Bromo-1H-pyrazolo[3,4-b]pyridine is an organic compound, and attention should be paid to its flammability. When handling and storing, avoid contact with fire sources and high temperatures.It may be toxic to humans and appropriate protective measures such as gloves, glasses, and protective clothing should be worn when operating. Avoid inhalation, ingestion, or skin contact.When using it, the safe operating procedures of the laboratory should be observed, and the waste should be properly disposed of to avoid pollution to the environment.

Application
5-Bromo-1H-pyrazolo[3,4-b]pyridine (CAS 875781-17-2) is a key heterocyclic building block widely used in medicinal chemistry and drug discovery. Its fused pyrazole-pyridine core, with a bromine atom at the 5-position, serves as a versatile scaffold for the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and TBK1 inhibitors). The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) for late-stage diversification, while the NH group allows alkylation or acylation. This purine bioisostere facilitates rapid structure-activity relationship (SAR) studies and construction of focused compound libraries. It is also used in agrochemical research and as a precursor for functionalized heterocycles. High purity (>97%) ensures reproducible biological assay results and scalable synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.


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