7-Deazaguanine(CAS#7355-55-7)
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S60 - This material and its container must be disposed of as hazardous waste. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
Introduction
7-Deazaguanine, also known as 7-deazaguanine, is an organic compound with a special structure. Its chemical formula is C5H5N5O and its relative molecular mass is 163.13.
In terms of properties, 7-deazaguanine is a white crystalline solid, insoluble in water and soluble in some organic solvents such as dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF). It is stable under acidic conditions, but decomposes under alkaline conditions.
7-Deazaguanine plays an important role in biology, especially in the construction and modification of nucleic acids. It is a special base that can be used by some bacteria and fungi to replace adenine (adenine) to form different nucleosides (nucleoside) in RNA and DNA. 7-Deazaguanine also has applications in the development of fungal antibiotics and anticancer drugs.
In the preparation method, 7-deazaguanine can be prepared by chemical synthesis. A common method is to synthesize the target product by tandem reaction using the corresponding pyrrole reagent as the starting material.
In terms of safety information, due to the professional application of 7-deazaguanine in the laboratory, the relevant toxicity and safety information has not been fully studied and understood. Therefore, when using or handling, it is necessary to follow the corresponding safety procedures and take necessary personal protective measures, such as wearing gloves and protective glasses. When handling chemicals, direct contact with the skin and inhalation of its dust should be avoided.
Application
7-Deazaguanine (CAS 7355-55-7) is a purine nucleobase analog in which the nitrogen at position 7 of the guanine ring is replaced by a carbon atom. This modification confers unique biological properties and enhanced metabolic stability. It serves as a versatile heterocyclic scaffold in medicinal chemistry and drug discovery, particularly for the development of kinase inhibitors (e.g., DYRK1A, CLK1, and Haspin) targeting cancer, neurodegenerative disorders, and viral infections. As a key building block, it enables the synthesis of modified nucleosides, nucleotides, and oligonucleotides for antisense therapy, PCR probes, and RNA interference research. In agrochemical research, it is used to design novel antiparasitic and herbicidal agents. Its rigid, planar structure allows precise molecular recognition in enzyme active sites. High purity ensures reproducible results in SAR studies and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 7-deazaguanine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
