1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, methyl ester(CAS#394223-02-0)

Introduction

Methyl 7-azaindole-2-carboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Methyl 7-azaindole-2-carboxylic acid is a white to pale yellow crystalline solid.- Solubility: It is soluble in organic solvents such as chloroform, dimethylformamide and methylene chloride, but insoluble in water.Use:- Methyl 7-azaindole-2-carboxylic acid is an important intermediate in organic synthesis. It can be used in the synthesis of various nitrogen-containing heterocyclic compounds, such as indole derivatives and pyrrole derivatives.Method:- There are several methods for the preparation of methyl 7-azaindole-2-carboxylate, one of which is commonly used to synthesize by epoxidation and acid hydrolysis of indolequinoline derivatives.Safety Information:- Methyl 7-azaindole-2-carboxylate is generally safe under normal use, but safe handling is still required.- It is an organic compound, take care to avoid contact with skin and eyes. Appropriate personal protective equipment such as laboratory gloves and goggles should be worn when in use.- When storing, methyl 7-azaindole-2-carboxylate should be placed in an airtight container to avoid exposure to air and high temperatures, ignitions, etc.

Application
Methyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate (CAS 394223-02-0) is a functionalized azaindole derivative valued as a versatile intermediate in medicinal chemistry and pharmaceutical research. The fused pyrrole-pyridine core serves as a purine bioisostere, while the methyl ester at position 2 enables diverse transformations including hydrolysis to carboxylic acid, reduction to hydroxymethyl, or conversion to amides for structure-activity relationship (SAR) studies. This scaffold is extensively used in the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and TBK1). It also finds applications in the development of antiviral agents, CNS drugs, and agrochemicals. Its high purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.