2-BROMO-5-METHOXYPYRAZINE(CAS#143250-10-6)

Introduction

2-Bromo-5-methoxypyrazine is an organic compound with the chemical formula C6H5BrN2O. The following is a description of its nature, use, preparation and safety information:

Properties: 2-Bromo-5-methoxypyrazine is a solid substance with a white or white-like color. It is stable at room temperature and pressure, but may decompose at high temperatures. Its solubility in water is relatively low, but it is better in organic solvents.

Application: 2-bromo-5-methoxypyrazine is widely used in organic synthesis. It can be used as an intermediate for the synthesis of various organic compounds, such as drugs, pesticides, dyes and photosensitive materials. It can also be used as a catalyst for organic synthesis reactions.

Preparation method: The synthesis of 2-bromo-5-methoxypyrazine is usually completed by bromination reaction and nucleophilic substitution reaction. A common method of preparation is the reaction of 2-bromopyrazine with methanol to produce 2-bromo-5-methoxypyrazine. The specific synthesis steps can be adjusted as needed.

Safety information: 2-bromo-5-methoxypyrazine is a relatively safe compound under normal use conditions, but the following points should be noted:

1. It may be irritating to the eyes and skin, so direct contact should be avoided during operation.

2. avoid inhalation of its powder or solution, so as not to cause respiratory discomfort.

3. Wear suitable personal protective equipment such as protective gloves, glasses and protective clothing during use.

4. in the use, storage and handling process should pay attention to the generation of fire and static electricity, to prevent its contact with combustible substances, in order to avoid fire or explosion.

2-Bromo-5-methoxypyrazine (CAS 143250-10-6) is a valuable heterocyclic building block widely used in medicinal chemistry and agrochemical research. The bromine atom at the 2-position enables efficient cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira, while the methoxy group at the 5-position provides electronic modulation and metabolic stability. This scaffold serves as a key intermediate for the synthesis of kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, and antibacterial compounds. Its pyrazine core is found in many bioactive molecules targeting cancer, inflammation, and infectious diseases. The compound also facilitates rapid structure-activity relationship (SAR) studies through sequential functionalization. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-bromo-5-methoxypyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.