2-Chloropyrazine(CAS#14508-49-7)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29339990 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | III |
Introduction
2-Chloropyrazine is an organic compound. The following is an introduction to some of the properties, uses, preparation methods and safety information of 2-chloropyrazine:Quality:- Appearance: 2-chloropyrazine is a white or off-white crystalline solid.- Solubility: 2-chloropyrazine has low solubility in water and is relatively soluble in organic solvents such as ethanol and methylene chloride.- Chemical properties: 2-chloropyrazine has strong alkalinity and can neutralize with acids.Use:- Pesticide field: 2-chloropyrazine can be used as one of the raw materials for insecticides and fungicides, and has good bactericidal and tickicidal activity.- Chemical research: 2-chloropyrazine is also used in organic synthesis, catalysts, etc.Method:- There are many preparation methods for 2-chloropyrazine, and the common method is obtained by the reaction of 2,5-dichloropyridine and isocyanate.Safety Information:- 2-Chloropyrazine is an organic compound that requires the general safety practices of organic chemistry laboratories, such as wearing protective equipment (gloves, goggles, etc.).- It may be irritating to the eyes, skin, and respiratory system, avoid contact with the eyes, skin, and ventilate well.- Keep away from fire and flammable substances during storage and use.- In case of accidental ingestion or inhalation, seek medical attention promptly.
Application
2-Chloropyrazine (CAS 14508-49-7) is a versatile heterocyclic building block serving as a critical intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. The chlorine atom at the 2-position acts as an excellent leaving group, enabling nucleophilic aromatic substitution (SNAr) reactions to efficiently introduce diverse nucleophiles, constructing complex molecular architectures. In medicinal chemistry, it is instrumental in developing APIs, particularly pyrazinamide analogs for tuberculosis therapy and other nitrogen-containing heterocycles targeting CNS disorders and oncology. The compound is also used to prepare hetaryloxy benzoxaboroles with antimalarial activity and serine β-lactamase inhibitors. In agrochemistry, it is utilized to produce herbicides, insecticides, and fungicides with enhanced targeting efficacy. Additionally, 2-chloropyrazine serves as an electrolyte additive in lithium-sulfur battery research. Xinchem offers custom synthesis and contract manufacturing of high-purity 2-chloropyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
