3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER(CAS#1458-01-1)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 2933997500 |
Introduction
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylic acid is a white crystalline solid.- Solubility: It is less soluble in water but can be soluble in organic solvents such as ethanol and dimethylformamide.- Chemical structure: It contains two amino groups and one chlorinated group in its chemical structure.Use:- Scientific research field: It can also be used as a reagent in research and experiments, for chemical reactions and synthesis.Method:- Methyl 3,5-diamino-6-chloropyrazine-2-carboxylic acid can be prepared by a variety of synthetic pathways, and the common method is to react aminocarboxylic acid with chloropyrazine in the reaction.Safety Information:- Wear appropriate protective equipment such as lab gloves, goggles, and lab coats when handling and touching methyl 3,5-diamino-6-chloropyrazine-2-carboxylate.- It should be operated in a well-ventilated environment to avoid inhaling its dust or gases from its solution.- Contaminated areas and tools should be thoroughly washed and waste should be properly disposed of after treatment.
Application
Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (CAS 1458-01-1) is a high‑purity heterocyclic building block with a unique pyrazine core functionalized by two amino groups, a chlorine atom, and a methyl ester. It is best known as Amiloride EP Impurity A (USP Related Compound A), serving as an essential reference standard for quality control, analytical method validation, and impurity profiling of the potassium‑sparing diuretic drug Amiloride during pharmaceutical development and GMP manufacturing. The diamino and chloro groups enable diverse substitution patterns for creating structural analogs targeting kinases, proteases, and G protein‑coupled receptors. The methyl ester can be hydrolyzed to the corresponding carboxylic acid for further derivatization, making it a versatile building block for the synthesis of antibacterial drug candidates, agrochemicals (herbicides and fungicides), and specialty materials. High purity ensures reproducible results in high‑throughput screening and scalable GMP processes. Xinchem offers custom synthesis and contract manufacturing of this key pharmaceutical intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
