3-Aminopyrazine-2-carboxylic acid methyl ester(CAS#16298-03-6)

Introduction

Methyl 3-aminopyrazine-2-carboxylate is an organic compound. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Methyl 3-aminopyrazine-2-carboxylic acid is a white crystalline solid.- Solubility: It is difficult to dissolve in water and can be dissolved in some organic solvents such as ethanol and ether.Use:- Methyl 3-aminopyrazine-2-carboxylic acid is commonly used as a reagent in organic synthesis.Method:- The preparation method of methyl 3-aminopyrazine-2-carboxylic acid is often prepared by reacting pyrazine-2-carboxylic acid with methanol at a suitable temperature in an appropriate solvent. Reactions often require long reaction times and suitable catalysts.Safety Information:- Methyl 3-aminopyrazine-2-carboxylate is a low-toxicity substance, but it is still necessary to pay attention to safe use and storage.- When using, avoid direct contact with skin and eyes, and rinse immediately with plenty of water if it does. Appropriate personal protective equipment such as gloves and goggles should be worn.- When storing, methyl 3-aminopyrazine-2-carboxylate should be kept in a dry, cool, well-ventilated place, away from fire sources and flammable substances.

Application
Methyl 3-aminopyrazine-2-carboxylate (CAS 16298-03-6) is a versatile heterocyclic building block with an amino group at the 3-position and a methyl ester at the 2-position of the pyrazine ring. The amino group facilitates amide coupling and heterocycle formation, while the methyl ester enables hydrolysis to the corresponding carboxylic acid for further derivatization. This scaffold is a key intermediate in the synthesis of bioactive molecules, including novel EGFR and other kinase inhibitors for targeted cancer therapy. It also serves as a core structure for developing antibacterial agents, notably antituberculosis drugs, as well as anti-inflammatory compounds. Its pyrazine ring is found in numerous FDA-approved therapeutics, providing optimal target binding and metabolic stability. In agrochemical research, derivatives are utilized for herbicide and fungicide development. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.