5-Bromo-6-chloropyrazin-2-amine(CAS#173253-42-4)
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2811 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
Introduction
It is an organic compound with the chemical formula C4H3BrClN2. The following is a brief description of its nature, use, preparation and safety information:
Nature:
-Appearance: White solid crystal.
-Solubility: It is soluble in organic solvents such as ethanol, dimethyl ether and dichloromethane at room temperature.
-Melting point: Its melting point is about 171-173°C.
Use:
-Chemical Intermediates: Often used as intermediates in organic synthesis for the synthesis of other compounds, such as drugs, pesticides and dyes.
-Drug research: It is also used in the field of drug research for the development and synthesis of potential drug molecules.
Method:
The preparation of the table can be carried out by the following steps:
1. React 5-bromo -6-chloropyrazine with ammonia to generate calcium.
Safety Information:
-Safety evaluation: The toxicity and safety evaluation of the salt have not been fully studied, so care is required when using it.
-protective measures: in the operation, should wear protective glasses, gloves and protective clothing. Avoid inhalation or contact with skin.
-Waste Disposal: Disposal of waste is subject to local regulations to avoid release into the environment.
Please note that this is only a brief introduction to the doctor, and specific information needs to refer to relevant literature or consult professionals.
Application
5-Bromo-6-chloropyrazin-2-amine (CAS 173253-42-4) is a high-value dihalogenated aminopyrazine building block widely used in medicinal chemistry and pharmaceutical research. This heterocyclic compound features strategically positioned bromine and chlorine atoms, enabling regioselective functionalization via cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Negishi) to rapidly construct diverse pyrazine-based libraries. The primary amine at the 2-position provides an additional handle for amide bond formation, supporting comprehensive structure-activity relationship (SAR) studies. In drug discovery, this compound serves as a versatile precursor for developing kinase inhibitors, notably showing promise as a CDK2 inhibitor for cell cycle regulation and cancer therapeutics. It is also a key intermediate for synthesizing antibacterial agents against Mycobacterium tuberculosis and other resistant pathogens, as well as antiviral and anti-inflammatory drug candidates. Beyond pharmaceuticals, this scaffold supports agrochemical development of pesticides and herbicides, along with applications in material science for dyes and functional chemicals. High purity ensures reproducible results from high-throughput screening to scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 5-Bromo-6-chloropyrazin-2-amine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
