2,5-Dichloropyrazine(CAS#19745-07-4)
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| HS Code | 29339900 |
Introduction
2,5-Dichloropyrazine is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 2,5-dichloropyrazine:Quality:- Appearance: 2,5-Dichloropyrazine is a white crystalline solid.- Solubility: 2,5-dichloropyrazine has low solubility in water and is soluble in organic solvents such as ethanol, acetone, etc.- Chemical properties: 2,5-Dichloropyrazine has strong oxidizing and reducing properties and can react with many other compounds.Use:- Pesticide: 2,5-Dichloropyrazine is a broad-spectrum fungicide that can be used in agriculture to control fungal diseases on crops.Method:- 2,5-Dichloropyrazine can be prepared by the reaction of 2,5-dichloroaniline with 3-aminopyridine.Safety Information:- 2,5-Dichloropyrazine is a toxic compound that is harmful to the human body. Skin contact, inhalation, or ingestion of large amounts of 2,5-dichloropyrazine may cause poisoning and should be used with caution and care should be taken to avoid prolonged exposure.- During use, appropriate protective measures such as gloves, protective eyewear, and respiratory protective equipment should be taken.- When storing and handling 2,5-dichloropyrazine, avoid contact with strong oxidants, acids, etc., to avoid dangerous chemical reactions.
Application
2,5-Dichloropyrazine is a versatile heterocyclic building block extensively used in pharmaceutical and agrochemical R&D. The two reactive chlorine atoms enable regioselective nucleophilic substitution and palladium-catalyzed cross-couplings (Suzuki-Miyaura, Buchwald-Hartwig) to construct diverse pyrazine-based libraries. It serves as a key intermediate for synthesizing kinase inhibitors, antiviral agents (e.g., anti-HCV compounds), and antibacterial drugs such as pyrazinamide analogs. In crop protection, it is utilized to develop systemic fungicides and herbicides with enhanced metabolic stability. The rigid pyrazine core improves target binding affinity and bioavailability. High purity ensures reproducible SAR studies and scalable GMP synthesis. Xinchem offers custom synthesis and contract manufacturing of 2,5-dichloropyrazine from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
