3,5-Dichloro-2-Methylpyrazine(CAS#89284-38-8)

Introduction

3,5-Dichloro-2-Methylpyrazine is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: Colorless to light yellow solid- Soluble: insoluble in water and soluble in organic solventsPurpose: It has a unique structure and can participate in a variety of organic reactions and is used to construct complex organic molecular structures.Method:There are several ways to prepare 2-methyl-3,5-dichloropyrazine, such as:- It can be obtained by the reaction of 2,3-dichloropyridine and methyl compounds under appropriate conditions.- It can also be obtained by chlorination by reacting pyridine and succinic anhydride in the presence of alkali.Safety Information: It may cause irritation and damage to the skin, eyes, and respiratory tract.- Avoid direct contact with skin and eyes, and wear personal protective equipment such as gloves and goggles if necessary.- Proper laboratory safety regulations and operating procedures should be followed during handling and handling to avoid hazards such as toxic gases or fires.

Application
3,5-Dichloro-2-methylpyrazine (CAS 89284-38-8) is a versatile heterocyclic building block widely used in pharmaceutical and agrochemical research. The two reactive chlorine atoms at positions 3 and 5 enable selective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid introduction of diverse substituents. The methyl group at position 2 provides additional steric and electronic modulation. This scaffold serves as a key intermediate for the synthesis of bioactive molecules, including kinase inhibitors (e.g., JAK, BTK, CDK), antiviral agents, antibacterial compounds, and antifungal drugs. In crop protection, it is utilized in the development of herbicides, fungicides, and insecticides with enhanced bioavailability and environmental safety. Its pyrazine core offers excellent metabolic stability and target binding affinity, facilitating structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 3,5-dichloro-2-methylpyrazine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.