2-Bromo-5-nitrobenzoic acid（CAS# 943-14-6)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29163990 |
Introduction
2-Bromo-5-nitrobenzoic acid is an organic compound with the chemical formula C7H4BrNO4. The following is a description of its nature, use, preparation and safety information:
Nature:
- 2-Bromo-5-nitrobenzoic acid is a yellow solid crystal, odorless.
-It is insoluble in water at room temperature, but soluble in organic solvents such as ethanol, chloroform and dimethyl sulfoxide.
-It has a certain degree of stability, but it can react in the presence of strong oxidants.
Use:
- 2-Bromo-5-nitrobenzoic acid is often used as an important intermediate in organic synthesis reactions.
-It can react with other compounds to form new organic compounds.
-It can also be used to prepare fluorescent dyes, pesticides and pharmaceutical chemicals.
Method:
- 2-Bromo-5-nitrobenzoic acid can be prepared by the following steps:
1. benzoic acid is reacted with concentrated nitric acid to obtain nitrobenzoic acid.
2. adding bromine to react with nitrobenzoic acid under appropriate conditions to generate 2-Bromo-5-nitrobenzoic acid.
Safety Information:
- 2-Bromo-5-nitrobenzoic acid is an organic compound, and attention should be paid to its toxicity.
-In the operation, should wear protective glasses and gloves, avoid skin contact.
-Operate in a well-ventilated environment to avoid inhaling dust or gas from the substance.
-If an overdose of the substance is taken by mistake or inhaled, consult a doctor immediately and inform the doctor of the situation.
-Keep away from fire and heat and store in a cool, dry place.
Application
2-Bromo-5-nitrobenzoic acid is a multifunctional halogenated aromatic building block widely used as a pharmaceutical intermediate and organic synthesis reagent. Its ortho-bromo and meta-nitro substitution pattern enables orthogonal functionalization: the bromine participates in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura) for C–C bond formation, while the carboxylic acid allows amidation or esterification. This compound is a key intermediate in the synthesis of Balsalazide, an anti-inflammatory drug for ulcerative colitis. It is also employed in preparing analgesics, anticancer agents, fluorescent dyes, pesticides, and functional materials. The nitro group can be reduced to an amine, providing an additional handle for molecular diversification. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-Bromo-5-nitrobenzoic acid with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
