5-Bromoquinoline-2-carboxylic acid(CAS#1017412-53-1)

Introduction

5-bromoquinoline-2-carboxylic acid is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Quality:- Appearance: 5-bromoquinoline-2-carboxylic acid is a white to off-white solid powder.- Solubility: It is soluble in chloroform, dichloromethane and ethanol, slightly soluble in ether and benzene, insoluble in water.Use:- 5-bromoquinoline-2-carboxylic acid is widely used in organic synthesis as a starting material and intermediate in the synthesis of other organic compounds.- Carboxylic acid groups are present in its molecules, which can participate in acylation reactions, esterification reactions, and condensation reactions, etc., and are used to construct complex organic compound frameworks.Method:- The preparation method of 5-bromoquinoline-2-carboxylic acid can be obtained by acidifying 5-bromoquinoline and sodium cyanide to form 5-bromoquinoline-2-nitrile, which is then converted into 5-bromoquinoline-2-carboxylic acid through hydrolysis reaction.Safety Information:- 5-Bromoquinoline-2-carboxylic acid is a chemical that can be harmful to humans, the environment, and animals.- Wear appropriate protective equipment during use and avoid contact with skin and eyes.- When storing and handling, follow relevant safety operating procedures and avoid contact with oxidants and acids.- In terms of waste disposal, it should be disposed of in accordance with local laws and regulations to prevent environmental pollution.- For detailed safety information on use and storage: refer to the relevant Safety Data Sheet (SDS) or consult the supplier.

Application
5-Bromoquinoline-2-carboxylic acid is a functionalized quinoline derivative widely used as a key intermediate in medicinal chemistry. The bromine at the 5-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the carboxylic acid allows amide or ester formation for rapid structure-activity relationship (SAR) studies. This scaffold is employed in the synthesis of potent kinase inhibitors targeting cancer (e.g., EGFR, PI3K, CDK), as well as antibacterial, antimalarial, and antiviral agents. Its rigid quinoline core enhances target binding affinity and metabolic stability. Additionally, it serves as a building block for fluorescent probes, agrochemicals, and organic materials. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.