2,4-Dichloro-5-fluoronitrobenzene(CAS#2105-59-1)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| Hazard Note | Irritant |
Introduction
2, is an organic compound with the chemical formula C6H3Cl2FNO2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2, is white crystalline solid.
-Melting point: About 90-93 degrees Celsius.
-Boiling Point: Not applicable.
-Solubility: 2. It is soluble in some organic solvents, such as dimethylformamide, dichloromethane and dichloroethane.
Use:
- 2, the main use of the compound is as an intermediate for the synthesis of other organic compounds.
-It is commonly used in the field of pesticides and pharmaceuticals.
Method:
- 2, can be synthesized by substitution reaction of nitrobenzene. The specific preparation method involves multiple steps and reagents, and the specific steps may vary depending on the reaction conditions and requirements.
Safety Information:
- 2, is an organic compound that may have some toxicity. Appropriate protective measures, such as gloves, goggles and respiratory protection, should be taken when exposed to the substance.
-Avoid inhalation or contact with skin, eyes and clothing.
-When using or storing the compound, take care to observe safe operating procedures and ensure good ventilation.
-Conform to local environmental regulations and legal restrictions and requirements when handling the substance.
Application
2,4-Dichloro-5-fluoronitrobenzene (CAS 2105-59-1, C₆H₂Cl₂FNO₂) is a highly functionalized, multi-halogenated nitrobenzene derivative. It is a key pharmaceutical intermediate and advanced building block for drug discovery, primarily used for the efficient synthesis of fluorinated pharmaceutical compounds, including potent protease inhibitors and antibacterial agents, as well as in the production of high-value agrochemicals such as selective herbicides and fungicides. Its unique substitution pattern, featuring a combination of electron-withdrawing nitro and chloro groups and a strategically positioned fluorine atom, activates the aromatic ring for regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-coupling reactions. This versatile intermediate supports the rapid construction of focused drug-like libraries and complex organic scaffolds, making it indispensable for high-throughput medicinal chemistry programs, fragment-based lead optimization, and scalable GMP manufacturing. Xinchem offers high-purity 2,4-dichloro-5-fluoronitrobenzene with flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing, scaled from R&D to commercial tons. Contact us for a competitive quote and global supply.
