3-CHLORO-4-FLUORONITROBENZENE(CAS#350-30-1)
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | CZ0720000 |
| HS Code | 29049090 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
3-chloro-4-fluoronitrobenzene. The following is an introduction to some of its properties, uses, manufacturing methods and safety information:Quality:Appearance: 3-chloro-4-fluoronitrobenzene is a colorless or yellowish crystal.Solubility: Soluble in organic solvents such as ethers, ketones and alcohols, slightly soluble in water.Use:3-chloro-4-fluoronitrobenzene is mainly used as a pesticide intermediate. It has an insecticidal effect in agriculture and can prepare a variety of animal and plant pesticides.Method:A common method for the preparation of 3-chloro-4-fluoronitrobenzene is obtained by the reaction of bromobenzene chloride with fluoronitrobenzene. Bromobenzene chloride and fluoronitrobenzene are first mixed, then reacted under appropriate conditions, and finally the target product is obtained through steps such as cooling, crystallization and purification.Safety Information:3-chloro-4-fluoronitrobenzene is an organic compound with certain toxicity. Care must be taken to avoid inhalation, contact with the skin and ingestion into the mouth during use.When handling and storing, appropriate precautions such as wearing protective gloves, goggles, and protective clothing are required.Do not come into contact with combustible substances to avoid fire or explosion.During the disposal process, local environmental regulations should be consulted and disposed of in accordance with the prescribed methods.
Application
3-Chloro-4-fluoronitrobenzene (CAS 350-30-1) is a multifunctional halogenated nitroarene widely used as a key building block in pharmaceutical and agrochemical research. Its unique substitution pattern, featuring electron-withdrawing nitro, chloro, and fluoro groups, enables regioselective nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-coupling reactions. This intermediate serves as a critical precursor for the synthesis of potent antimicrobial, anti-inflammatory, and anticancer agents, as well as selective herbicides and fungicides. In drug discovery, it enables rapid construction of diverse heterocyclic libraries, including benzimidazoles, quinolines, and pyrimidines. Its high purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
