2-Ethoxy-5-(tributylstannyl)pyrimidine(2-Ethoxy-5-(tributylstannyl)pyrimidine)(CAS#1025746-10-4)

Introduction

2-Ethoxy-5-(tributylstannyl)pyrimidine is an organic compound. The following is a brief introduction to the properties, uses, preparation methods, and safety information of the substance:Quality:- Appearance: 2-Ethoxy-5-(tributylstannyl)pyrimidine is a white to pale yellow solid.- Soluble: Soluble in most organic solvents, such as alcohols, ethers, and other common organic solvents.Use:- 2-Ethoxy-5-(tributylstannyl)pyrimidine is commonly used as a reagent in organic synthesis. It is often used as a ligand or intermediate in the synthesis of other complex compounds.- In organometallic chemistry, it can also be used as a starting material for organotin reagents.Preparation:The preparation of 2-Ethoxy-5-(tributylstannyl)pyrimidine typically involves the following steps:1. Ethyl 2-bromoacetate is reacted with tributyltin compound to give ethyl 2-ethoxy-5-bromopyrrole acetate.2-Ethoxy-5-(tributylstannyl)pyrimidine is obtained by reacting ethyl 2-ethoxy-5-bromopyrrole acetate with ammonia or urea.Safety Information:- Limited information on the safety and toxicity of 2-Ethoxy-5-(tributylstannyl)pyrimidine is available.- The nature of its organotin compounds, which may be toxic to the environment.- Good laboratory practice should be followed during the procedure and appropriate personal protective measures such as gloves and protective eyewear should be taken.- When storing and handling, it should be kept in an airtight container and avoid contact with oxygen and moisture to prevent decomposition and oxidation reactions from occurring.

Application
2-Ethoxy-5-(tributylstannyl)pyrimidine is a specialty stannylated heterocycle widely used as a Stille cross-coupling reagent to introduce the 2-ethoxypyrimidine motif into complex aromatic and heteroaromatic scaffolds. This versatile building block enables efficient C–C bond formation under palladium catalysis, making it essential for constructing drug-like libraries and advanced synthetic intermediates. It is a key pharmaceutical intermediate for novel 5-substituted pyrimidine carbocyclic nucleoside drugs, and also supports the synthesis of agrochemicals and functional materials. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity reagent with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.