4-iodo-3-nitrobenzoic acid methyl ester（CAS# 89976-27-2)
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
Introduction
Methyl 4-iodo-3-nitrobenzoate is an organic compound, and its English name is Methyl 4-iodo-3-nitrobenzoate.
Quality:
- Appearance: White to beige solid
Use:
- Methyl 4-iodo-3-nitrobenzoate is commonly used in organic synthesis reactions and can be used as an intermediate in the synthesis of other compounds.
Method:
- Methyl 4-iodo-3-nitrobenzoate is usually obtained by reacting methyl p-nitrobenzoate with iodine under appropriate reaction conditions.
Safety Information:
- Methyl 4-iodo-3-nitrobenzoate is a chemical and should be handled in accordance with relevant laboratory safety procedures, avoid contact with skin and eyes, and avoid inhalation or ingestion.
- It needs to be stored properly, away from fire and high temperature environment, and kept in a dry and ventilated place.
- Please consult the Safety Data Sheet (SDS) for detailed safety information before performing any experiments or using them.
Application
Methyl 4-iodo-3-nitrobenzoate (CAS 89976-27-2) is a versatile, high-purity organic building block featuring both an iodine atom and a nitro group on a benzoate scaffold. This unique dual functionality makes it an essential pharmaceutical intermediate and a valuable reagent for complex organic synthesis.
The iodine atom serves as an excellent handle for palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig couplings, enabling the efficient construction of biaryl and heteroaryl scaffolds. Meanwhile, the nitro group can be selectively reduced to an amine, providing an additional site for further functionalization such as amidation or heterocycle formation. This compound is also used as a precursor for chemotherapeutic agents, as its derivatives have shown potential anti-cancer activity by being selectively reduced in tumor cells to produce cytotoxic agents. Due to its light sensitivity, it should be stored in a dark, dry place away from oxidizing agents.
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