2-Chlorobenzaldehyde（CAS# 89-98-5)
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 3 |
| WGK Germany | 1 |
| RTECS | CU5075000 |
| FLUKA BRAND F CODES | 8-9-23 |
| TSCA | Yes |
| HS Code | 29130000 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 2160 mg/kg |
Introduction
O-chlorobenzaldehyde. The following is an introduction to the properties, uses, preparation methods and safety information of o-chlorobenzaldehyde:
Quality:
- Appearance: O-chlorobenzaldehyde is a colorless or yellowish liquid.
- Odor: has a special aromatic odor.
- Solubility: Soluble in alcohols, ethers and aldehyde solvents.
Use:
- It can also be used as a raw material for pesticide synthesis, insecticides, and antifungal agents.
Method:
- O-chlorobenzaldehyde is usually prepared by the reaction of chloromethane and benzaldehyde under acidic conditions.
- The reaction requires the presence of a catalyst, which is commonly used to include platinum or rhodium complexes.
Safety Information:
- O-chlorobenzaldehyde is an irritating compound that may cause inflammation in contact with the skin and eyes.
- Observe appropriate safety measures such as wearing protective gloves and eye protection when using and handling.
- O-chlorobenzaldehyde should be stored in an airtight container, away from fire and high temperatures.
Application
2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, OCBA, CAS 89-98-5) is a highly reactive aromatic aldehyde that serves as a critical and versatile intermediate in the fine chemical, pharmaceutical, and agrochemical industries. Its unique bifunctional structure, featuring both an aldehyde group and a strategically positioned chlorine atom, makes it indispensable for synthesizing complex heterocyclic and chiral molecules.
In the pharmaceutical sector, 2-Chlorobenzaldehyde is a crucial starting material for the synthesis of high-value antibiotics, most notably penicillinase-resistant penicillins such as Flucloxacillin (or Cloxacillin) Sodium. The demand in this sector is non-cyclical and driven by the global production of essential generic antibiotics, requiring high purity and reliable supply. It is also used in the synthesis of other active pharmaceutical ingredients (APIs), including antihistamines and antimicrobial compounds. Furthermore, it serves as a building block for research, participating in one-pot Biginelli cyclocondensations to generate focused libraries of dihydropyrimidine derivatives.
In the agrochemical industry, 2-Chlorobenzaldehyde is a core intermediate for synthesizing a range of crop protection chemicals. It is a key raw material for manufacturing potent acaricides (miticides), including Tetradifon and Flutenzine, which are used to control mites on dry crops and fruit trees. It is also the intermediate for Inabenfide, a plant growth regulator used primarily in rice cultivation to control growth and lodging.
Beyond life sciences, 2-Chlorobenzaldehyde is utilized in several specialized industrial applications. It serves as an intermediate for producing electroplating brighteners (for nickel and zinc plating), where its derivatives improve surface finish, luster, and uniformity. It is also used in the synthesis of dyes, pigments, optical brighteners, and other fine chemicals. Its derivatives are employed in the rubber, tanning, and paper industries. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-Chlorobenzaldehyde to support your pharmaceutical, agrochemical, and specialty chemical development and production. Contact us for a competitive quote and reliable global supply.
