6-Trifluoromethylpyridazin-3(2H)-one(CAS#174607-36-4)

Introduction

6-(trifluoromethyl)pyrazine-3(2H)-one is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- Appearance: 6-(trifluoromethyl)pyrazine-3(2H)-one is a solid substance that appears as a white crystalline or crystalline powder at room temperature.- Solubility: 6-(trifluoromethyl)pyrazine-3(2H)-one has some solubility and is soluble in organic solvents such as ether, diethyl dicarboxylate and chloroform.Use:- Chemical intermediates: 6-(trifluoromethyl)pyrazine-3(2H)-one can be used as a chemical intermediate in organic synthesis for the synthesis of other compounds.- Pesticide research: This compound can also be used in pesticide research and development.Method:- Synthetic route: A common method for the synthesis of 6-(trifluoromethyl)pyrazine-3(2H)-one is carried out by esterification and aminolysis. The specific synthesis method can be found in the relevant chemical literature.Safety Information:- The compound may be irritating to the eyes, skin, and respiratory system, and appropriate precautions should be taken when exposed to it, such as wearing protective eyewear and gloves.- Care should be taken to avoid inhaling dust or contact with the skin when handling the substance, and it should be handled in a well-ventilated area. If necessary, wear a protective mask.- When storing and transporting 6-(trifluoromethyl)pyrazine-3(2H)-ketone, keep it away from ignition and oxidizing agents, and avoid contact with combustible substances.Please consult the relevant chemical literature and safety data sheets before use to ensure safe use of this compound.

Application
6-Trifluoromethylpyridazin-3(2H)-one (CAS 174607-36-4) is a high‑purity heterocyclic building block featuring a pyridazinone core with a lipophilic trifluoromethyl group. The CF3 group enhances metabolic stability, membrane permeability, and target binding affinity, while the lactam NH enables hydrogen bonding. This scaffold is widely used in medicinal chemistry for the synthesis of selective kinase inhibitors (e.g., JAK, BTK, CDK) targeting cancer, inflammation, and autoimmune diseases. It also serves as a key intermediate for antiviral, antibacterial, and antifungal agents. In agrochemical research, its derivatives show potent herbicidal and fungicidal activity, providing improved crop protection with lower toxicity. The rigid pyridazinone ring facilitates structure‑activity relationship (SAR) studies and fragment‑based drug discovery. Additionally, it is utilized in the development of fluorescent probes and materials for organic electronics. High purity ensures reproducible results in high‑throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.