6-chloro-4-methyl-2H-pyridazin-3-one(CAS#1834-27-1)

Introduction

6-Chloro-4-methyl-3-pyridazinone is an organic compound. Here is some information about its properties, uses, manufacturing methods, and safety:Quality:- Appearance: 6-Chloro-4-methyl-3-pyridazinone is a white to light yellow solid.- Solubility: Less soluble in water, but soluble in many organic solvents.- Stability: It is a relatively stable compound, but it can decompose at high temperatures, strong acids, or strong bases.- Molecular structure: 6-chloro-4-methyl-3-pyridazinone is a derivative of two carbon atoms on a pyridazine ring that are replaced by chlorine and methyl groups.Use:- 6-Chloro-4-methyl-3-pyridazinone has potential in the field of pesticides and can be used as an intermediate in the synthesis of new insecticides or herbicides.Method:- 6-Chloro-4-methyl-3-pyridazinone can be prepared by chemical synthesis. The specific method is as follows: 2-(trifluoromethyl)pyridine is obtained by reacting 2-hydroxypyridine with 1,1,1-trifluoroethylene, and then by reacting with cuprous chloride, and then going through further reaction and purification steps, 6-chloro-4-methyl-3-pyridazinone is finally obtained.Safety Information:- There are limited toxicity data for 6-chloro-4-methyl-3-pyridazione. When handling and use, general laboratory safety practices and operating procedures should be followed, and inhalation, contact with skin and eyes, and ingestion of the substance should be avoided.- Data on the environmental impact and ecotoxicity of the substance is also limited, and waste should be treated with caution and appropriate environmental guidelines should be followed.- The use and storage of 6-chloro-4-methyl-3-pyridazinone should be carried out in accordance with the respective national and regional regulations and regulatory requirements.

Application
6-Chloro-4-methyl-2H-pyridazin-3-one (CAS 1834-27-1) is a versatile heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. The presence of a chlorine atom at the 6-position and a methyl group at the 4-position on the pyridazinone core allows selective nucleophilic aromatic substitution and cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig) for rapid structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including JAK, BTK, and CDK inhibitors. It is also utilized in the development of antiviral, antibacterial, and antifungal agents, as well as in agrochemical research for herbicide and fungicide discovery. The pyridazinone core provides hydrogen bond donor/acceptor sites, enhancing target binding affinity and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.